Recombinant Rat Early growth response protein 1 (Egr1)

1. Study found an association between contextual fear conditioning deficits in alcohol-exposed animals with a decrease in Egr-1 mRNA expression in the infralimbic and prelimbic subregions of the medial frontal cortex (mPFC); conclude that memory processes in mPFC associated with the context-shock association phase are the most susceptible to the teratogenic effects of neonatal alcohol. PMID: 30346189
2. Egr-1 plays an important role in TGF-beta1-induced epithelial-to-mesenchymal transition (EMT)of renal tubular epithelial cells and metformin improves EMT while inhibiting Egr-1, which provides a potential novel target to combat renal fibrosis PMID: 30050950
3. high glucose alters tendon homeostasis through downregulation of the AMPK/Egr1 pathway and the expression of downstream tendon-related genes in tenocytes. PMID: 28266660
4. The expression of egr1 was rhythmic in the prefrontal cortex and dorsomedial hypothalamus and food reward diminished this rhythm. PMID: 29355377
5. Study speculates that during infant learning, specific early growth response protein 1 expressing cellular ensembles are "tagged" representing long-term memory formation, and that these cell ensembles may be reactivated during adult learning. PMID: 28391399
6. Highly expressed Egr-1 may be involved in the recruitment of RNA POL II in GDNF promoter II in a non-binding manner, and thereby involved in regulating GDNF transcription in high-grade glioma cells. PMID: 28187447
7. Forced swim stress (FS) prior to the complete Freund's adjuvant (CFA) injection enhanced the CFA-induced mechanical hypersensitivity and attenuated the increase in the expression of pCREB and Egr1 in the insular cortex (IC) and anterior cingulate cortex (ACC) of Sprague-Dawley rats. These findings suggested an FS-induced alteration of neuroplasticity in the IC and ACC following CFA injection. PMID: 28866293
8. This study demonstrating fear conditioning robustly and consistently induces Egr-1 expression in the lateral nucleus of the amygdala,hippocampus and medial prefrontal cortex. PMID: 28814471
9. PKA-mediated suppression of Ang-II-induced Egr-1 expression and phosphorylation of ERK may be among the mechanisms by which cAMP exerts its vasculoprotective effects PMID: 28460186
10. Egr-1 (and TGF-Beta1) are up-regulated by sustained hyperosmolarity in the renal medulla. PMID: 28673338
11. Results show an age-related reduction in the transcription of Egr1 in the dentate gyrus following spatial behavior, whereas in the area CA1, Egr1 is reduced at rest, but its transcription can be effectively driven by spatial behavior to levels equivalent to those observed in adult animals. PMID: 26972614
12. Results demonstrate that Zif268 functions within the medial prefrontal cortex (mPFC) to influence working memory, long-term memory, and social interaction time. Reinstitution of mPFC Zif268, using a novel adeno-associated-viral construct, abrogated gonadectomy (GNX)-induced working memory and long-term memory impairments, and reductions in social interaction time, but not GNX-induced depression-like behaviors. PMID: 27816701
13. Data suggest that TGFB2 (the most abundant growth factor in human milk) binding to Tgfb2r elicits robust/rapid response in small intestinal mucosal cells leading to stimulation of Egr1 transport to nucleus and cell differentiation; more than 15 Wnt signaling pathway genes have Egr1 binding sites/response elements; Egr1 binds to Axin1 promoter and functionally activates gene expression. (Axin1 = axis inhibition protein 1) PMID: 27697743
14. Ang-II-induced Egr-1 expression is mediated by STIM-1/Orai-1/Ca(2+) -dependent signaling pathways in vascular smooth muscle cells. PMID: 28105751
15. sublytic C5b-9-induced activation of Egr-1/p300-ATF3/Gadd45 axis plays a critical role in glomerular mesangial cells apoptosis in Thy-1N rats. PMID: 27190312
16. the loss of GCN5 activity and the induction of Egr-1, E2F1 and Bim are involved in the early brain injury (EBI) following subarachnoid haemorrhage (SAH) in rats. PMID: 28125090
17. Egr1 contributes to the transcriptional program associated with neuronal differentiation. PMID: 28076410
18. Mammillothalamic tract lesions in rats reduced activity in the retrosplenial cortex, as measured by expression levels of the immediate-early gene zif268 and the metabolic marker cytochrome oxidase; no significant changes were found in the dorsal hippocampus PMID: 27233617
19. Results show that miR-191 negatively regulates Egr-1 and controls neointima formation after vascular injury. PMID: 27057945
20. data indicate that Egr-1 promotes Abeta synthesis via transcriptional activation of BACE-1 and suggest that Egr-1 plays role in activation of BACE-1 and acceleration of Abeta synthesis in AD brain. PMID: 27576688
21. Forced swimming results in reduced DNA methylation at specific 5'-cytosine-phosphate-guanine-3' (CpG)s within c-Fos and Egr-1 gene promoters and untranslated regions in DG neurons. SAM significantly increases DNA methylation at these c-Fos and Egr-1 gene loci and inhibits c-Fos and Egr-1 induction. PMID: 27078100
22. This study indicated differential Egr-1 activation during development and adulthood in variants of fear conditioning paradigms. PMID: 26778782
23. In male rats pre-exposed to prenatal stress, observed a "protective" effect of prenatal stress on postnatal stress-induced downregulation of Egr1 expression, which may indicate that prenatal stress exposure may induce "resilience". PMID: 25239865
24. Egr1 contributes to diabetic nephropathy by enhancing mesangial cell proliferation and extracellular matrix production, in part by interacting with TGF-beta1. PMID: 26279418
25. Within the amygdala, zif268 expression participates in the extinction of conditioned fear. PMID: 26282370
26. The targeted knockdown of Zif268 in the brain results in a non-recoverable retrograde amnesia. PMID: 26238574
27. There is competitive interaction between redox-sensitive transcription factors Egr1 and Sp1 in the early phases of gastric ulcer development. PMID: 26547966
28. Orchestrated Egr1 and Pitx1 activities depending on specific central and peripheral regulatory inputs could be responsible for physiologically variable Lhb gene promoter activation in vivo. PMID: 25258388
29. Results showed that the expression of Arc, but not zif268, was significantly increased in the cerebellum following motor skill learning PMID: 25249385
30. Egr-1 governs pulmonary vascular remodelling and the development of characteristic vascular neointimal lesions PMID: 25028387
31. Egr1 gene is actively and selectively transcribed in a major sub-population of male LHB+ cells indicates a largely conserved role in gonadotroph function and has provided a basis for further defining this role. PMID: 25139489
32. Egr-1 mRNA expression has a complex relationship to fear learning in different brain regions and variants of context conditioning. PMID: 24976583
33. Inhibition of Egr1 expression underlies the anti-mitogenic effects of cAMP in vascular smooth muscle cells. PMID: 24534707
34. The hyperacetylation of H3K9 at Egr-1 binding sites in promoter region II of the gdnf gene can up-regulate the binding of Egr-1 to increase gdnf gene transcription in glioma cells. PMID: 25201174
35. Overall, the acute stress and partner familiarity produced a similar pattern of results in adolescents and adults, with both age groups sensitive to the social context. PMID: 24613747
36. The results suggest that EGR-1 seems to play a critical role in myocardial reperfusion injury. PMID: 24365880
37. Decreased expression of Arc and Egr-1 might be involved with instability of synaptic plasticity in tinnitus. PMID: 24704997
38. litter composition modified sex effects on methylation of Egr1 in nucleus accumbens PMID: 23460384
39. Zif268 in the dorsal horn of the spinal cord is an important molecular correlate of endocannabinoid-mediated Fear-conditioned analgesia PMID: 23873727
40. The findings suggest that increased expression of Egr-1 within the prefrontal cortex is associated with contextual fear conditioning in the context pre-exposure facilitation effect paradigm. PMID: 23973447
41. Deep brain stimulation of mediodorsal thalamic nucleus produces robust increases in the expression of zif-268, but not c-fos in the frontal cortex. PMID: 23660497
42. number and pattern of granule cell expression of zif268 during rest is preserved in aged animals, despite a significant decline in exploration-related zif268 expression PMID: 24028087
43. These studies establish a new role for Egr-1 in regulating the expression of the mitogenic epidermal growth factor receptor PMID: 23763269
44. Our results demonstrate that the IEGs, egr1 and arc, may significantly contribute to synaptic reorganization induced by the kindling of seizures PMID: 23744421
45. Interactions between elevated peritoneal fluid TNF-alpha and overexpression of follicular Egr1 expression may affect downstream protease pathways impeding ovulation in endometriosis. PMID: 23427178
46. Apelin-13 induced the proliferation and migration of vascular smooth muscle cells as well as the upregulation of osteopontin via the upregulation of Egr-1. PMID: 23973488
47. Up-regulation of EGR-1 and NAG-1, along with higher reactive oxygen species load may positively regulate the intrinsic pathway of apoptosis for the NSAID mediated chemoprevention of colorectal cancer. PMID: 23435960
48. The results indicate a key role for heightened methylation of the Egr-1 binding site in hypoxia-mediated programming of PKCepsilon gene repression PMID: 23427086
49. Egr-1 plays an important role in regulating the HO-1 production induced by ischemia-reperfusion (IR). Downregulation of Egr-1 expression might be one of the mechanisms whereby ischemic postconditioning confers protection against pulmonary IR insult. PMID: 22878149
50. expression of Egr-1 is up-regulated and temporally distributed in certain cell types after trauma to skeletal muscles. PMID: 22918836

Show More

Hide All

KEGG: rno:24330

STRING: 10116.ENSRNOP00000026303

UniGene: Rn.9096