Recombinant Rat Fibulin-5 (Fbln5)

Code CSB-YP896264RA
MSDS
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Source Yeast
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Code CSB-EP896264RA
MSDS
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Source E.coli
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Code CSB-EP896264RA-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP896264RA
MSDS
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Source Baculovirus
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Code CSB-MP896264RA
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Fbln5
Uniprot No.
Alternative Names
Fbln5; DanceFibulin-5; FIBL-5; Developmental arteries and neural crest EGF-like protein; Dance; Embryonic vascular EGF repeat-containing protein; EVEC
Species
Rattus norvegicus (Rat)
Expression Region
24-448
Target Protein Sequence
QQQCTNG FDLDRQTGQC LDIDECRTIP EACRGDMMCV NQNGGYLCIP RTNPVYRGPY SNPYSTSYSG PYPAAAPPVP ASNYPTISRP LVCRFGYQMD EGNQCVDVDE CATDSHQCNP TQICINTEGG YTCSCTDGYW LLEGQCLDID ECRYGYCQQL CANVPGSYSC TCNPGFTLND DGRSCQDVNE CETENPCVQT CVNTYGSFIC RCDPGYELEE DGIHCSDMDE CSFSEFLCQH ECVNQPGSYF CSCPPGYVLL EDNRSCQDIN ECEHRNHTCT PLQTCYNLQG GFKCIDPIVC EEPYLLIGDN RCMCPAENTG CRDQPFTILF RDMDVVSGRS VPADIFQMQA TTRYPGAYYI FQIKSGNEGR EFYMRQTGPI SATLVMTRPI KGPRDIQLDL EMITVNTVIN FRGSSVIRLR IYVSQYPF
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN.
Gene References into Functions
  1. upregulation of fibulin-5 is involved in the beneficial effect of RIPostC against cerebral I/R injury PMID: 28251683
  2. Fibulin-5 overexpression attenuated reactive oxygen species expression, which in turn decreased apoptosis and blood-brain barrier (BBB) permeability following middle cerebral artery occlusion and reperfusion. PMID: 26021746
  3. Fibulin-5 plays a role not only in the tissue repair and remodelling after renal tubular oxidative damage but also in renal cell carcinoma metastasis, presumably as a cytokine. PMID: 20942562
Subcellular Location
Secreted. Secreted, extracellular space, extracellular matrix.
Protein Families
Fibulin family
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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