Recombinant Rat G2/mitotic-specific cyclin-B1(Ccnb1)

Code CSB-YP004806RA
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Source Yeast
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Code CSB-EP004806RA
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Source E.coli
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Code CSB-EP004806RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP004806RA
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Source Baculovirus
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Code CSB-MP004806RA
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Ccnb1
Uniprot No. P30277
Alternative Names Ccnb1G2/mitotic-specific cyclin-B1
Species Rattus norvegicus (Rat)
Expression Region 1-423
Target Protein Sequence MALRVTRNTK INTENKAKVS MAGAKRVPVA VAASKPLLRS RTALGDIGNK VSEQSRIPLK KETKKLGSGT VTVKALPKPV DKVPVCEPEV ELDEPEPEPV MEVKHSPEPI LVDTPSPSPM ETSGCAPAEE YLCQAFSDVI LAVSDVDADD GGDPNLCSEY VKDIYAYLRQ LEEEQSVRPK YLLGREVTGN MRAILIDWLI QVQMKFRLLQ ETMYMTVSII DRFMQDSCVP KKMLQLVGVT AMFIASKYEE MYPPEIGDFA FVTNNTYTKH QIRQMEMKIL RVLNFSLGRP LPLHFLRRAS KIGEVDVEQH TLAKYLMELS MLDYDMVHFA PSQIAAGAFC LALKILDNGE WTPTLQHYLS HTEESLLPVM QHLAKNIVMV NRGLTKHMTI KNKYATSKHA KISTLAQLNC TLVQNLSKAV TKA
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Gene References into Functions
  1. These results unveil a previously unrecognized role for mitochondrial cyclin B1 in the oxidative damage associated with neurological disorders. PMID: 26109654
  2. that MAD2B may play an important role in high glucose-mediated podocyte injury of diabetic nephropathy via modulation of Cdh1, cyclin B1, and Skp2 expression PMID: 25651564
  3. Expression of cyclin B1 mRNA and localization of cyclin B1 protein are dependent on the developmental stages of spermatogenic cells. PMID: 12399820
  4. Data show that cyclin A1 and cyclin B1 gene expression is controlled by E(2) at a concentration of 10(-9)uM only in stages IX-I of spermatogenesis. PMID: 22180637
  5. Cytoplasmic polyadenylation element binding protein 1 (CPEB1) is associated with cyclin B1 mRNA; this interaction is enriched at the centrosome. PMID: 21865454
  6. introduction of cyclin B1 dsRNA into rat oocytes selectively depleted the corresponding mRNA, further ablating its protein product PMID: 15291744
  7. Cdc2/cyclin B1 interacts with and modulates inositol 1,4,5-trisphosphate receptor (type 1) functions. PMID: 16237118
  8. analysis of expression of Cyclin D1, E, A and B1 in neurons of cerebral cortex and hippocampus PMID: 18278459
  9. the expressions of Swedish double mutation of amyloid precursor protein (Swe-APP)increased mRNA and protein levels of cyclin D1 and cyclin B1 PMID: 18438935
  10. Data show that aberrant expression of cyclin B1 takes place in the brain after chronic cerebral hypoperfusion in retired rat. PMID: 18775106
  11. Cdh1 is a novel Cdk5 substrate that mediates cyclin B1 neuronal accumulation in excitotoxicity PMID: 18818692

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Subcellular Location Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein Families Cyclin family, Cyclin AB subfamily
Database Links

KEGG: rno:25203

STRING: 10116.ENSRNOP00000025297

UniGene: Rn.9232

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