||Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).
||Cytoplasm, cytoskeleton, Cytoplasmic vesicle membrane, Lipid-anchor, Endoplasmic reticulum, Golgi apparatus, Cytoplasmic vesicle, autophagosome
||High expression in liver and brain, lower in lung and heart and very low in kidney and skeletal muscle (at protein level). Present in all brain regions and spinal cord (at protein level).
NOD-like receptor signaling pathway
Apelin signaling pathway
FoxO signaling pathway