Recombinant Rat Growth/differentiation factor 8 (Mstn)

1. Myostatin protein was expressed in the perineal striated muscles, and also in the smooth muscle cells of the penile corpora, arteries and veins, and aorta. PMID: 28539643
2. Both myostatin and GDF11 affected synapse formation in isolated rat cortical neuron cultures. PMID: 28533206
3. Results show that Myostatin and follistatin protein expression is reduced in the long-term hypertrophied myocardium from spontaneously hypertensive rats with heart failure. PMID: 27128567
4. Mstn knockout rat model provides a novel means to study the role of Mstn in metabolism and Mstn-related muscle hypertrophy PMID: 27289021
5. Myostatin can be used as an early marker of doxorubicin induced cardiotoxicity. PMID: 26927339
6. Myostatin staining associated with myonuclei was less in HLS rats compared with controls. PMID: 26205544
7. This study demonstrated that stretching activated myostatin gene expressions and increased the proliferation of connective tissue but did not avoid muscle fiber atrophy or induce sarcomerogenesis of denervated rat soleus muscle PMID: 25960249
8. myostatin deficiency in rat did not have negative consequences to muscle fibres and ECM as in mouse models. Suggests that greatest impact of myostatin in regulation of muscle mass may not be to induce atrophy directly, but to block hypertrophy signaling. PMID: 25640143
9. activation of AMPK plays a key role in increasing the level of FoxO1, FoxO3a, and myostatin in gastrocnemius after exercise-induced muscle damage PMID: 26342801
10. study reports on a novel functional crosstalk between the IGF-1 and MSTN signaling pathways, as mediated through interaction between PI3K/Akt and Smad3 PMID: 26151859
11. Endurance training prevents TWEAK but not myostatin-mediated cardiac remodelling in cancer cachexia PMID: 25575785
12. IGF-1 regulates myostatin transcription through the activation of the NFATc3 transcription factor in an IP3 /calcium-dependent manner. This study demonstrates a role of calcium-dependent signaling pathways in the mRNA expression of myostatin. PMID: 23255067
13. myostatin gene expression is programmed by nutritional status in neonatal life. PMID: 22684687
14. Quadriceps atrophy after ACL transection involves increased levels of myostatin, atrogin-1, and muscle ring finger 1 mRNA and the accumulation of ubiquitinated protein. PMID: 22854904
15. Results suggest that myostatin functions as a negative regulator in the later stages in the hypertrophy of masseter muscle induced by clenbuterol, whereas IGF works as a positive regulator in the earlier stages. PMID: 22696074
16. Expression of myostatin and follistatin mRNA is increased in muscle and subcutaneous fat of sedentary diabetic rats compared with sedentary controls. PMID: 22332899
17. The ratio of follistatin/myostatin could be used to monitor the progress of target muscle atrophy and recovery. PMID: 22033906
18. myostatin mRNA expression was higher in exercised high-fat fed rats compared with a sedentary high-fat fed group PMID: 21539891
19. Effects of training and androgens on MYOPRO and FOLLI concentrations in blood and skeletal muscle, were investigated. PMID: 20801187
20. These results strongly suggest that myostatin can play an essential role in the adaptation of skeletal muscle to hypoxic environment. PMID: 20884321
21. Sepsis and glucocorticoids do not upregulate the expression and activity of myostatin in skeletal muscle. PMID: 20677217
22. Stretching and electrical stimulation reduce the accumulation of MyoD, myostatin and atrogin-1 in denervated rat skeletal muscle. PMID: 20191313
23. Despite the absence of endogenous myostatin, L6E9 myoblasts expressed functional Activin receptors type II. Results suggest that L6E9 myoblasts provide a spontaneous myostatin knock-out in vitro model. PMID: 20396675
24. monoclonal antibody blockadein mesenchymal sdtem cells promotes myogenesis and recovery of motor function following transplantation into dystrophic animals PMID: 19903098
25. eccentric contractions intensity plays a key role in impairment of muscular function and activation of myostatin PMID: 19959771
26. maternal undernutrition during gestation results in the aberrant regulation of myostatin and follistatin-like-3 in the placenta and skeletal muscle PMID: 20103742
27. Myostatin expression and secretion were significantly upregulated in proliferating satellite cells in response to high concentrations of HGF which may reestablish quiescence. PMID: 20007454
28. myostatin is a repressor of physiological cardiac muscle growth and function. PMID: 19736304
29. During chronic heart failure, decreased skeletal muscle trophism is combined with unchanged myostatin and reduced follistatin expression. PMID: 20002838
30. study proposes that dexamethasone-induced muscle loss is mediated, at least in part, by the upregulation of myostatin expression PMID: 12721153
31. A significant negative linear correlation was found between myostatin abundance and muscle atrophy degree, suggesting that myostatin might probably play an important role in denervation-induced muscle atrophy. PMID: 16450055
32. myostatin in serum acts on skeletal muscle and negatively regulates early postnatal muscle growth PMID: 16575154
33. alterations in the balance between IGF-1 and myostatin in skeletal muscle wasting in uremia and the hypertrophic response to exercise PMID: 16871256
34. The results obtained showed that intense training caused a decreased expression of myostatin mRNA in white and red skeletal muscles but an increase in cardiac muscle. PMID: 16873457
35. Myostatin promoter activity increased in cells exposed to dexamethasone, but this increase was partially blocked by addition of the glutamine. PMID: 16919545
36. expressed in association with muscle enlargement after compensatory overload independently of pituitary state PMID: 16941139
37. Results support an important role for myostatin in muscle atrophy in physiological and physiopathological situations where myostatin expression is induced. PMID: 17395701
38. The mRNA expression pattern of myostatin was quite similar to that of decorin during prenatal and postnatal development of rat skeletal muscle. PMID: 17679144
39. Ovariectomy and estrogen increase levels of myostatin. PMID: 17959844
40. Prolonged cold ischemia accelerate graft myofibrosis by down-regulating expression of GDF-8, which affectsy the myofibrosis process of rat abdominal aortic grafts. PMID: 18089396
41. Profibrotic role of myostatin in Peyronie's disease: myostatin is overexpressed in the PD plaque, partly because of myofibroblast generation. PMID: 18422491
42. Role for myostatin in protein metabolism and more specifically in the regulation of translation in skeletal muscle. PMID: 18801898
43. Recombinant hGH and/or testosterone anabolic effects in the muscle are mediated by a different expression of MGF/IGF-IEa/myostatin, which is related to the pituitary function. PMID: 18841527
44. Myometrial cells are myostatin sensitive, myostatin mRNA levels are modulated in vivo in rats during the estrous cycle, and in response to steroid deprivation and replacement. PMID: 18845635
45. A significant increase was observed in insulin-like growth factor-1 expression, and a significant decrease was observed in myostatin and mechano growth factor in rats with peripheral venous occlusion. PMID: 19125275
46. These alterations in myostatin expression in the skeletal and heart muscle following exercise training could help to explain the beneficial anti-catabolic effects of exercise training in CHF. PMID: 19218333
47. myostatin plays a positive role in tendon maintenance and that exogenous protein administration stimulates proliferation and growth of early repair tissue PMID: 19591015

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KEGG: rno:29152

STRING: 10116.ENSRNOP00000038159

UniGene: Rn.44460