Recombinant Rat Insulin-like growth factor II (Igf2)

1. We aimed to investigate whether TSN protected H9c2 cardiomyocytes from AngII-induced activation of IGF-2R pathway (IGF-2 and IGF-2R )and hypertrophy by mediating through Estrogen receptors PMID: 28812967
2. Post-weaning high-fat (HF) diet intake resulted in the reduction of small follicles in adulthood, whereas maternal HF diet had long-term deleterious consequences on female offspring steroidogenesis and coincided with alteration of the upregulation of the imprinted gene Igf2 and changes in ovarian circadian rhythms. PMID: 28417351
3. The results showed that f1 offspring exposed to p,p'-DDE exhibited impaired glucose tolerance, abnormal insulin secretion, beta-cell dysfunction and altered Igf2 and H19 expression induced by Igf2/H19 hypomethylation, which could be transferred to the F3 offspring through the male germ line. PMID: 28867213
4. The IGF2 was further de-regulated to assess its mechanism in miR-193-5p-downreuglation induced angiogenic regulation. PMID: 28735866
5. The hypomethylation observed at the H19 DMR corroborates with aberrant expression of Igf2 and H19 imprinted genes in the resorbed embryos sired by ERb agonist-treated males PMID: 28362134
6. IGF2 expression in the rat brain both in basal condition and following learning predominantly derives from the maternal allele. PMID: 26495851
7. Ancestral TCDD exposure may promote epigenetic transgenerational alterations of imprinted gene Igf2 in adult somatic tissue. PMID: 26455773
8. This study suggests that bisphenol A exposure during early life can result in generational transmission of glucose intolerance and beta-cell dysfunction in the offspring through male germ line, which is associated with hypermethylation of Igf2 in islets. PMID: 26276081
9. Allele-specific and total expression of hippocampal Igf2 is affected by maternal, grandmaternal caloric restriction in a strain and sex-specific manner. PMID: 24845189
10. IGF-II may therefore contribute to the mechanisms of neuroprotection. PMID: 24667322
11. We found that paternal folate deficiency induced a decrease in fetal liver folate content, IGF-2 expression, and the percentage of 5-mC in the fetal whole brain. PMID: 23229416
12. IGF-IR-mediated activation of intracellular signaling may play a critical role during oxidative stress-induced apoptosis in necrotizing enterocolitis. PMID: 22434232
13. IGF2 may play a role in tooth differentiation. PMID: 21959847
14. IMP3 as a glioblastoma-specific proproliferative and proinvasive marker acting through IGF-2 resulting in the activation of oncogenic PI3K and MAPK pathways PMID: 21613208
15. maternal exposure to a low protein diet and folic acid during gestation alters gene expression of Igf2 and H19 in the liver by regulating the DNA methylation of these genes PMID: 20671425
16. Inhibitory avoidance learning leads to an increase in hippocampal expression of IGF-II, which requires the transcription factor CCAAT enhancer binding protein beta and is essential for memory consolidation PMID: 21270887
17. Results indicate that undernutrition alters the timing and intensity of neonatal beta-cell ontogeny, and suggest that pancreatic IGF-2 in undernourished rats may contribute to the partial suppression of the developmental wave of beta-cell apoptosis. PMID: 19648158
18. Our results show that maternal malnutrition ameliorates beta-cell mass in undernourished goto-kakizaki fetuses and a specific pancreatic IGF-2 increase may be instrumental in this effect. PMID: 19919529
19. Data provide evidence for the role for estrogen in acquisition of imprint at Igf2/H19 DMR in testis and help in understanding molecular mechanism of environmental estrogens impacting male fertility. PMID: 19683557
20. Expression of IGF-II in early experimental hepatocellular carcinomas PMID: 12532445
21. Igf2 protectes theca-interstitial cell cells from apoptosis, reducing DNA fragmentation. PMID: 15833775
22. IGF-2 expression in amoeboid microglial cells in the developing brain is related to their activation. PMID: 16448778
23. The increased cardiac IGF-II, IGF-IIR, caspase 9, and cellular apoptosis were also found in hypertensive rats with abdominal aorta ligation. PMID: 16825605
24. Hepatocellular carcinomas of the albumin SV40 T-antigen transgenic rat display fetal-like re-expression of Igf2. PMID: 17393425
25. IGF2 and IGF1R have roles in beta cell mass anomaly in embryonic pancreas PMID: 17476475
26. The insulin-like growth factor II expression was found to be predominant in hepatocellular carcinoma and in early preneoplastic lesions. PMID: 17554210
27. Presence of IGF-II variants, including proIGF-II, IGF-II(1-87), and mature IGF-II, in the rat circulation during postnatal life, challenging current impression that IGF-II is absent from sera of adult rats. PMID: 17628003
28. Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression. PMID: 17724018
29. PCR analysis of Igf2 gene by using of microsatellite D1Mgh22 has shown polymorphism between hereditary hypertriglyceridemic and Lewis rats. PMID: 18418699
30. Report abnormal expression of insulin-like growth factor-II and its dynamic quantitative analysis at different stages of hepatocellular carcinoma development. PMID: 18693177
31. A brain region- and cell type-specific responses to estrogen in rat brain, suggesting that Igf signaling may mediate the estrogen function in the hippocampus. PMID: 18946176
32. nicotine exposure prevents the decrease of IGF-II processing in the maternal compartment; this may represent a compensatory mechanism allowing the mother to counteract the negative influence of nicotine on fetal growth and development PMID: 19494366
33. IGF2 overexpression induced a clear protection against IL1B-induced beta-cell apoptosis. PMID: 19592596
34. dual role of IGF-II in the control of IGF1R dependent cell apoptosis and involved activation of IGF2R signaling PMID: 19764351
35. The placenta, the primary source of IGF-II synthesis in pregnancy, drives plasma volume expansion, and that IGF-II is among the regulatory factors of the gestational plasma volume increment. PMID: 19776249

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KEGG: rno:24483

STRING: 10116.ENSRNOP00000047037

UniGene: Rn.118681