Recombinant Rat Metabotropic glutamate receptor 1 (Grm1), partial

Code CSB-YP009931RA
MSDS
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Source Yeast
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Code CSB-EP009931RA
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Source E.coli
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Code CSB-EP009931RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP009931RA
MSDS
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Source Baculovirus
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Code CSB-MP009931RA
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Grm1
Uniprot No.
Alternative Names
Grm1; Gprc1a; Mglur1Metabotropic glutamate receptor 1; mGluR1
Species
Rattus norvegicus (Rat)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
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Target Background

Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. May function in the light response in the retina.
Gene References into Functions
  1. ERK that interacts with and phosphorylates mGluR1a is involved in the regulation of the trafficking and signaling of mGluR1. PMID: 27796752
  2. Fyn binds to mGluR1a at a consensus binding motif located in the intracellular C-terminus (CT) of mGluR1a in vitro. Active Fyn phosphorylates mGluR1a at a conserved tyrosine residue in the CT region. In cerebellar neurons and transfected HEK293T cells, Fyn-mediated tyrosine phosphorylation of mGluR1a is constitutively active and facilitates surface expression of mGluR1a and potentiates mGluR1a postreceptor signaling. PMID: 28948209
  3. Under control conditions, mGluR1alpha dimer expression increased between juvenile and adolescence (209-328%), while monomeric levels remained consistent. Dimeric mGluR5 was steadily expressed across all time points; monomeric mGluR5 was present in juveniles, dramatically declining at adolescence and adulthood (-97-99%). PMID: 27721389
  4. GABACR and mGluR1 have roles in contrast response functions of Sprague-Dawley and P23H rat retinal ganglion cells PMID: 29253887
  5. The goal of this experiment was to determine the effects of mGluR1, as well as mGluR5, antagonism on these parameters. Results show that mGluR1 is an important mediator of impulsive choice, and they provide further evidence that delay order presentation is an important variable that influences drug effects in delay discounting. PMID: 28088471
  6. Results suggest that activation of group I metabotropic glutamate receptor regulates the excitability of rat retinal ganglion cells by inhibiting inwardly rectifying potassium channels and hyperpolarization-activated cation channels. PMID: 27306787
  7. These results add mGluR-mediated Ca(2+)-signalling in the thalamic reticular nucleus to the state-dependent modulators of the thalamocortical system. PMID: 27041217
  8. mGluR5 positive modulation decreased dendritic spine densities in the NAc shell and core, but was without effect in the dorsal striatum, whereas increased spine densities in the NAc were observed with mGluR1a positive modulation PMID: 27618534
  9. Results suggest that activation of mGluR1/5 in the lateral hypothalamus induces an orexigenic effect via activation of the endocannabinoid system. PMID: 27542344
  10. decrease in mGluR1 and inositol trisphosphate receptors immunoreactivity may be attributed to a feedback mechanism preventing excessive intracellular Ca(2+) release PMID: 26318863
  11. Activation of mGluR1 or mGluR5 alone is sufficient to induce a negative shift in the equilibrium potential for GABA-A receptor mediated currents following TBS in juvenile rat hippocampal neurons. PMID: 26389591
  12. At hippocampal synapses, rather than being controlled simply by the magnitude of the postsynaptic calcium rise, LTP induction requires the coordinated activation of distinct sources of Ca2+ and mGluR1-dependent facilitation of NMDAR function. PMID: 26758963
  13. Results unveil an essential role of NRG1/ErbB tone in sustaining mGluR1 function, thus modulating the functional state of the dopaminergic system and consequently the release of DA in the terminal areas PMID: 25266126
  14. The expression of mGluR1 is increased in hippocampus and prefrontal cortex in late prenatal stress offspring. PMID: 25894678
  15. we find that miR-137 is transiently upregulated in response to metabotropic glutamate receptor 5 (mGluR5), but not mGluR1 activation. Consequently, acute interference with miR-137 function impedes mGluR-LTD expression. PMID: 26095359
  16. mGluR1 antagonist AIDA prevents the onset of seizures and increased generation of NO in the cerebral cortex of GEP rats in response to acoustic stimulation. mGluR1 plays an important role in the pathogenetic mechanisms of audiogenic seizures. PMID: 26033576
  17. The data suggest that group I metabotropic glutamate receptors play a key role in sensory integration of temporomandibular joint nociceptive input to the neurons at the spinomedullary region and are largely independent of estrogen status. PMID: 25934040
  18. prenatal cocaine exposure triggers PKC-mediated hyper-phosphorylation of the mGluR1 leading to uncoupling of mGluR1 from its signaling components Homer1 and Gq PMID: 24626340
  19. Glutamate stimulates local protein synthesis in the axons of rat cortical neurons by activating AMPA receptors and metabotropic glutamate receptors. PMID: 26134564
  20. Results provide unequivocal demonstration of the intrasynaptic localization of mGlu1 receptors in GABAergic synapses and confirm their peri-junctional enrichment in glutamatergic synapses PMID: 25377770
  21. Results suggest that mGlu1 and 5 receptor activation within the lateral hypothalamus elicits dose-dependent eating responses, and provide new data showing that injection into sites bracketing the lateral hypothalamus is ineffective or less effective PMID: 25449406
  22. Study shows that mGlu1/5 activation leads to phosphorylation of a specific TRPV1 residue via PKC and AKAP150 in trigeminal sensory neurons and that functional interactions between glutamate receptors and TRPV1 mediate muscle tissue mechanical hyperalgesia PMID: 25451626
  23. Results suggest that endogenously expressed mGluR1a and mGluR1b variants assemble into dimeric receptor complexes mGluR1a/b and that this association affects the trafficking of the variants in neurons, namely on the mGluR1b delivery to the dendrites PMID: 25158311
  24. Results suggest that signaling molecules recruited by the activation of group I mGluRs collaboratively or oppositely control the optimal expression of synaptic plasticity at excitatory synapses in the spinal trigeminal nucleus oralis. PMID: 25149878
  25. The role of group I metabotropic glutamate receptors 1 and 5 (mGluRs1/5) in inducing plastic changes at mossy fiber- perisomatic inhibitory interneurons synapses, was examined. PMID: 25161282
  26. Findings from the present study showed that trigeminal neurons express mGluR1alpha, mGluR2/3 and mGluR8, while SGCs only express mGluR1alpha and mGluR8. PMID: 24495291
  27. Evidence for a similar mGluR1/mGluR5 functional dependence is shown in medium spiny striatal neurons. PMID: 25113912
  28. mGlu1 receptor modulates late-LTP in apical dendrites and basal dendrites PMID: 23978512
  29. In hippocampus metabotropic glutamate receptor 1 (mGluR1) decreased during gestation and lactation periods but increased during the ablactation period. PMID: 22362014
  30. A calcium-dependent protein-protein interaction between a synaptic kinase and mGluR1a is found, constituting a feedback loop desensitizing mGluR1a. PMID: 23426668
  31. Presynaptic release of glutamate with subsequent activation of NMDA receptors is necessary for IL-1beta-induced synapse loss. PMID: 22311599
  32. The data indicate that presynaptic mGluR(1) contributes to an activity-dependent mechanism that regulates retinogeniculate excitation and therefore plays a significant role in the thalamic gating of visual information. PMID: 22973005
  33. NAC might be a potential therapeutics targeting for group I mGlus activation in the treatment of PD. PMID: 22442667
  34. Taken together with our previous results, it is suggested that mGluR1 be involved in tonic inhibition of EC-HIP synaptic enhancement, while mGluR5 be involved in maintenance of persistent inflammatory pain-associated EC-HIP synaptic enhancement. PMID: 22172929
  35. Autoradiography of rat brain shows that binding of [(18) F]FPIT 1-(2-[18 F]fluoro-3-pyridyl)-4-(2-isopropyl-1-oxo- isoindoline-5-yl)-5-methyl-1H-1,2,3-triazole, a PET ligand, is aligned with high specific binding in the cerebellum and thalamus. PMID: 21668889
  36. mGluR1-mediated synaptic transmission contributes substantially to regulation of neuronal output in the hippocampus via intracellular divalent calcium Ca2+-wave activation of small conductance SK- and transient receptor potential (TRP)-mediated channels. PMID: 21576272
  37. Sleep-deprivation induces changes in GABA(B) and mGlu receptor expression and has consequences for synaptic long-term depression PMID: 21980366
  38. Group I metabotropic mGluR1 activates feed-forward inhibition of prefrontal cortex pyramidal cells to impair cognitive functions. PMID: 21613584
  39. Pain-related inhibition of medial prefrontal cortex neurons in the arthritis model depends on mGluR1-mediated endogenous activation of GABA(A) receptors. PMID: 21880942
  40. Metabotropic receptors and estrogen receptor (ER)alpha interact in neurons to produce neuroprotection against beta-amyloid toxicity. PMID: 21984253
  41. Data suggest that mechanisms underlying the diminished mGluR1-LTP in cocaine-withdrawn rats involve an altered GABAergic synaptic inhibition mediated by modulation of downstream endocannabinoid signaling. PMID: 21749491
  42. The depression of synaptic transmission following oxygen/glucose deprivation is prevented by metabotropic glutamate receptor 1 (mGluR1) or adenosine A3 receptor inhibition. PMID: 21849555
  43. Group I mGluRs thus powerfully modulate synaptic excitation of hippocampal interneurons and mediate inter-synaptic cross-talk. PMID: 21185314
  44. Group I mGluR-dependent protein synthesis and associated long-term depression is dependent on hippocmpal activation of calcium/calmodulin-dependent protein kinase IIalpha (CaMKIIalpha). PMID: 21593322
  45. Group I mGluR1 expression decreased in rat flocculus after unilateral labyrinthectomy. PMID: 19894497
  46. These data represent the first evidence that synaptic activation of mGluR1 can modulate the intrinsic excitability properties of hippocampal neurons. PMID: 21269340
  47. mGluR1 rather than mGluR5 can account for the pain-related changes of excitatory and inhibitory synaptic transmission in the CeLC through a mechanism that involves inhibition of inhibitory transmission PMID: 21162731
  48. in vitro activation of mGluR1 by bath-application of their well-known agonist (S)-3,5-dihydroxyphenylglycine increased the number of Fos-expressing neurons in the Vo area PMID: 20848228
  49. Data show that mGlu2 and mGlu4 subunits (but not mGlu2 and mGlu1) can heteromerize. PMID: 20826542
  50. At parallel fibre to Purkinje cell synapses, AMPAR activation inhibits the mGluR1 slow excitatory postsynaptic potentials via activation of a src-family tyrosine kinase. PMID: 20603338

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 3 family
Tissue Specificity
Predominantly expressed in cerebellar Purkinje cells, CA2-CA3 pyramidal cells of the hippocampus, and mitral and tufted cells of the olfactory bulb.
Database Links
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