Recombinant Rat Poly [ADP-ribose] polymerase 1 (Parp1), partial

1. Glucose oxidase/glucose induced stria vascularis marginal cells (MCs) death via upregulation of PARP-1 expression, accumulation of polyADP-ribose (PAR) polymers, decline of mitochondrial membrane potential and nuclear translocation of apoptosis-inducing factor, which all are biochemical features of parthanatos. PMID: 29049980
2. results indicated that PARP-1 inhibition significantly enhanced transcription of genes involved in antioxidative defense and in regulation of mitochondria function, but was not able to ameliorate cells viability affected by Abeta. PMID: 29128369
3. the inhibition of ROCK leads to reduced myocardial infarction size and cardiomyocyte apoptosis via the PARP/ERK signaling pathway. PMID: 28656263
4. Inhibition of PARP-1 and hypothermia lead to an alteration of injury but this effect is sexually dimorphic. PMID: 28698869
5. PARP1 plays a pivotal role in glucose oxidase-induced marginal cell death. PMID: 26526840
6. Work demonstrated the critical role of PARP-1 in diabetic heart injury, and suggested that PARP-1 inhibition may be a feasible strategy for the treatment of diabetic cardiomyopathy. PMID: 27027354
7. The data provide the first evidence that PARP1 exacerbates cardiac hypertrophy by PARylation of FoxO3. PMID: 27686254
8. might be involved in streptomycin ototoxicity by regulating AIF translocation in cochlear hair cells PMID: 26963167
9. Recurrent hyperglycemia in neonatal rats is associated with upregulation of PARP-1 and NF-kappaB expression and subsequent microgliosis but not neuronal cell death in the cerebral cortex. PMID: 26200703
10. PARP1 is involved in the development of diabetic retinopathy, and minocycline is able to inhibit PARP1 expression and decrease cellular apoptosis PMID: 26165350
11. This study demonstrate that the down-regulation of PARP-1 activity contributes to reducing post-ischemic brain damage via protection of the neurovascular unit. PMID: 26220474
12. Perinatal asphyxia leads to PARP-1 overactivation, increasing the expression of pro-inflammatory cytokines and cell death in mesencephalon, effects prevented by systemic neonatal nicotinamide administration. PMID: 25835215
13. Modulation of PARP-1-mediated oxidative cell injury by ring finger protein 146 (RNF146) in cardiac myocytes PMID: 24842055
14. SirT1 and Parp1 expression precedes oxidative stress in rats subjected to transient cerebral focal ischemia. PMID: 25440363
15. The N terminus of nuclear GAPDH binds with PARP-1, and this complex promotes PARP-1 overactivation both in vitro and in vivo. PMID: 25882840
16. Data show that MP-124 induced micronuclei through poly(ADP-ribose) polymerase-1 (PARP-1) inhibition. PMID: 25868125
17. Results show that activation of PARP-1 may change the expression of membrane proteins and Ca2 + permeability of AMPA channels, thus affecting the function and survival of CA1 pyramidal cells PMID: 24954469
18. CXCL12 downstream signalling through Akt kinase was responsible for the reduction of PARP-1 activity which switched cell death from necrosis to apoptosis PMID: 24988468
19. Advanced oxidation protein products induce intestine epithelial cell death through a redox-dependent,JNK and PARP1 mediated pathway. PMID: 24434514
20. Nicotinamide may have a therapeutic potential in neurodegenerative processes due to the decreased levels of oxidative stress, apoptosis, and PARP-1 activity. PMID: 24151909
21. These data demonstrated that cellular NAD depletion and decline of SIRT1 activity play critical roles in PARP-1-mediated epileptic neuronal death in the hippocampal neuronal model of acute epilepsy. PMID: 23994215
22. These results show for the first time that the DNA damage/PARP-1 signaling pathway is important for pulmonary arterial hypertension development. PMID: 24270264
23. roles of poly(ADP-ribose) polymerase-1 (PARP-1) and transcription factor Yin Yang 1 (YY1) in Cxcl12 transcription PMID: 23555743
24. results identify PARP1 as a key regulator of ERalpha in controlling ERalpha transactivation. PMID: 23493398
25. These results suggest that PARP-1 is important for myofibroblast differentiation and the pathogenesis of pulmonary fibrosis. PMID: 23260200
26. Data indicate that in diabetes mellitus, tempol reduces albuminuria associated with reduction of podocyte apoptosis and decreasing oxidative stress via poly(ADP-ribose) polymerase (PARP)-1 signaling. PMID: 22555049
27. intermittent hypoxia induces cell death in rat primary cerebellar granule cells by stimulating oxidative stress PARP-mediated calpain and AIF activation. PMID: 22405498
28. analysis of novel poly(ADP-ribose) polymerase-1 inhibitors PMID: 22153339
29. PARP-1 mediates angiotensin II-induced plasminogen activator inhibitor-1 and fibronectin in mesangial cells. PMID: 21613793
30. an increased expression of PARP-1 during Sertoli cell development, together with a decrease in the expression of antioxidant enzymes. PMID: 21375507
31. TopoIIbeta is an essential component in DSBs repair in primary neurons in both Ku70 and PARP-1 dependent pathways. PMID: 22019940
32. Strong activation of calpain and poly(ADP-ribose) polymerase (PARP) was found in rhodopsin mutants. PMID: 21765948
33. These results outline a PARP-1-dependent signal transduction mechanism that links contraction rate and Ca(2+) mobilization with the expression of genes underlying morphological changes in cardiomyocytes. PMID: 21635224
34. PARP-1 overactivation in necrotizing enterocolitis may drive mucosal cell death and PARP-1 may be a novel therapeutic target in NEC. PMID: 21399558
35. PARP inhibition prevents oxidative stress of bladder induced by acute urinary retention. PMID: 21416227
36. Results suggest that excitotoxicity of spinal networks is mainly directed to neurons and mediated by PARP-1 death pathways. PMID: 20502958
37. the difference between a long-lived and a short-lived species tested, man and rat, is directly mirrored by the enzymatic parameters of recombinant PARP-1. PMID: 20399804
38. Poly(ADP-ribose) polymerase (PARP)-1-independent apoptosis-inducing factor (AIF) release and cell death are induced by eleostearic acid and blocked by alpha-tocopherol and MEK inhibition. PMID: 20177052
39. the existence of two PARP-1 pools associated with the nuclear matrix of rat liver and the ability of PARP-1 automodification to facilitate its binding to the nuclear matrix were shown. PMID: 20122899
40. Findings provide rationale for development and further studies of PARP inhibitors and PARP inhibitor-containing combination therapies. PMID: 19854869
41. Intraendothelial poly(ADP-ribose) polymerase activation may contribute to endothelial dysfunction associated with aging. PMID: 11906946
42. Activation of poly(ADP-ribose) polymerase contributes to endothelial dysfunction associated PMID: 12011985
43. report the novel finding that the enzymatic activity of PARP-1 promotes, in an beta-nicotinamide adenine dinucleotide-dependent fashion, the DNA binding of NF-kappaB in microglia exposed to lipopolysaccharides, interferon-gamma or beta-amyloid 1-40 PMID: 12675907
44. Poly(ADP-ribose) polymerase (PARP) is not observed in the hippocampus after exposure to immobilization stress; therefore the amount of PARP protein expression is significantly reduced following stress. PMID: 12802178
45. Adprt orthologs map to homologous chromosome regions at the termini of the q-arms of human and mouse chromosomes 1 and rat 13, with gene order being conserved between the rodents. PMID: 12826757
46. poly(ADP-ribose) turnover has a role in distinct pathways in meiotic and post-meiotic germinal cells PMID: 12870658
47. There is early activation of PARP after a cold lesion that is related to nNOS induction and supports the relevance of nNOS and/or PARP inhibition to therapeutic approaches of traumatic brain injury. PMID: 14580948
48. Data show that poly(ADP-ribose) polymerase 1 (PARP-1) is expressed during fetal development and undergoes complex developmental changes in expression, and that inhibition of PARP-1 activity differentially affects expression of surfactant proteins. PMID: 14754756
49. PARP activation has a role in mediating effects of local ischemia-reperfusion injury PMID: 14770035
50. PARP activation is an important mechanism in diabetic neuropathy and provides the first evidence for the potential therapeutic value of PARP inhibitors. PMID: 14988256

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KEGG: rno:25591

STRING: 10116.ENSRNOP00000004232

UniGene: Rn.11327