PARP1 poly(ADP-ribose)polymerase 1 is a multifunctional enzyme with a molecular weight of 116 kDa, consisting of three main structural domains: DNA binding domain, self-modification domain, and catalytic domain. PARP1 plays multiple important roles in cells, including DNA single-strand break repair, gene transcription regulation, and cell death regulation. When DNA is damaged, PARP1 is rapidly activated and recruits other repair proteins by forming a PARP-DNA complex to participate in DNA repair pathways such as base excision repair BER, non-homologous end joining NHEJ, and homologous recombination repair HRR. In addition, PARP1 changes chromatin structure and transcriptional activity through ADP ribosylation, interacts with transcription factors, and regulates gene expression. In severe DNA damage, the activation of PARP1 can also lead to NAD+ depletion and trigger cell death. The activity of PARP1 is regulated by tumor suppressor genes such as PTEN, and interacts with proteins such as ATM, BRCA1, and BRCA2 to participate in DNA damage response and cell cycle regulation. The development of PARP1 inhibitors has become an important strategy for treating specific types of cancer, especially in the treatment of ovarian cancer and breast cancer.
The following PARP1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
PARP1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA017457GA01HU | PARP1 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA010134 | Cleaved-PARP1 (A214) Antibody | Human,Mouse | ELISA,WB |
CSB-PA000059 | Cleaved-PARP1 (G215) Antibody | Human | WB, ELISA |
CSB-PA000080 | Cleaved-PARP1 (D214) Antibody | Human,Mouse | WB, ELISA |
CSB-MA000290 | PARP1 Monoclonal Antibody | Human | ELISA,WB |
CSB-MA000291 | PARP1 Monoclonal Antibody | Human | ELISA,WB |
CSB-MA000305 | PARP1 Monoclonal Antibody | Human | ELISA,WB |
CSB-PA966699 | PARP1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA436053 | PARP1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA405636 | PARP1 Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA890185 | Acetyl-PARP1 (K521) Antibody | Human,Mouse,Rat | WB,ELISA |
CSB-PA017457XA01HU | PARP1 Antibody | Homo sapiens (Human) | ELISA, WB (ensure identification of antigen) |
CSB-PA017457LA01HU | PARP1 Antibody | Human | ELISA, WB, IHC, IF |
CSB-PA017457LB01HU | PARP1 Antibody, HRP conjugated | Human | ELISA |
CSB-PA017457LC01HU | PARP1 Antibody, FITC conjugated | Human | |
CSB-PA017457LD01HU | PARP1 Antibody, Biotin conjugated | Human | ELISA |
CSB-RA160472A0HU | PARP1 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
CSB-RA581794A0HU | PARP1 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, IF, FC |
CSB-RA258431A0HU | PARP1 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
PARP1 Antibodies for Arabidopsis thaliana (Mouse-ear cress)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA589143XA01DOA | PARP1 Antibody | Arabidopsis thaliana | ELISA, WB (ensure identification of antigen) |
PARP1 Antibodies for Zea mays (Maize)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA931196XA01ZAX | PARP1 Antibody | Zea mays (Maize) | ELISA, WB (ensure identification of antigen) |
PARP1 Antibodies for Oryza sativa subsp. japonica (Rice)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA765912XA01OFG | PARP1 Antibody | Oryza sativa subsp. japonica (Rice) | ELISA, WB (ensure identification of antigen) |
PARP1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP017457MO CSB-EP017457MO CSB-BP017457MO CSB-MP017457MO CSB-EP017457MO-B |
Recombinant Mouse Poly [ADP-ribose] polymerase 1 (Parp1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PARP1 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP017457BO CSB-EP017457BO CSB-BP017457BO CSB-MP017457BO CSB-EP017457BO-B |
Recombinant Bovine Poly [ADP-ribose] polymerase 1 (PARP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PARP1 Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-YP017457CH CSB-EP017457CH CSB-BP017457CH CSB-MP017457CH CSB-EP017457CH-B |
Recombinant Chicken Poly [ADP-ribose] polymerase 1 (PARP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PARP1 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP017457RA CSB-EP017457RA CSB-BP017457RA CSB-MP017457RA CSB-EP017457RA-B |
Recombinant Rat Poly [ADP-ribose] polymerase 1 (Parp1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PARP1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP017457HU CSB-EP017457HU CSB-BP017457HU CSB-MP017457HU CSB-EP017457HU-B |
Recombinant Human Poly [ADP-ribose] polymerase 1 (PARP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP017459HU | Recombinant human Poly [ADP-ribose] polymerase 11(PARP11), partial | E.coli |
CSB-YP017459HU CSB-BP017459HU CSB-MP017459HU CSB-EP017459HU-B |
Recombinant human Poly [ADP-ribose] polymerase 11(PARP11), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP017457HU1 | Recombinant Human Poly [ADP-ribose] polymerase 1 (PARP1), partial | E.coli |
PARP1 Proteins for Xenopus laevis (African clawed frog)
Code | Product Name | Source |
---|---|---|
CSB-YP017457XBE CSB-EP017457XBE CSB-BP017457XBE CSB-MP017457XBE CSB-EP017457XBE-B |
Recombinant Xenopus laevis Poly [ADP-ribose] polymerase 1 (parp1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PARP1 Proteins for Oryza sativa subsp. japonica (Rice)
Code | Product Name | Source |
---|---|---|
CSB-YP765912OFG CSB-EP765912OFG CSB-BP765912OFG CSB-MP765912OFG CSB-EP765912OFG-B |
Recombinant Oryza sativa subsp. japonica Poly [ADP-ribose] polymerase 1 (PARP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PARP1 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Code | Product Name | Source |
---|---|---|
CSB-YP874170DXU CSB-EP874170DXU CSB-BP874170DXU CSB-MP874170DXU CSB-EP874170DXU-B |
Recombinant Cricetulus griseus Poly [ADP-ribose] polymerase 1 (PARP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PARP1 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E10705h | Human Poly ADP ribose polymerase,PARP ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 3.9 pg/mL |