Recombinant Rat Protein kinase C zeta type (Prkcz)

1. The current studies demonstrate that enhanced action potential firing produced by NGF was blocked by inhibitors of translation, but not transcription. In vitro studies showed that NGF elevated the protein levels of PKMzeta, which was also prevented by inhibitors of translation. Intraplantar injection of NGF produced a rapid and maintained increase in mechanical sensitivity whose onset was delayed by translation inhibit... PMID: 29288797
2. the overexpression of PKMzeta in hippocampal neurons immobilized GluA2-containing AMPA receptors. PMID: 29202853
3. Here we find that spatial conditioning by aversive active place avoidance or appetitive radial arm maze induces PKMzeta increases in dorsal hippocampus that persist from 1day to 1month, coinciding with the strength and duration of memory retention. PMID: 27417578
4. In contrast to adult rats, juveniles failed to show contextual fear responses at 4 d post-fear conditioning. Reconsolidation sessions 3 and 6 d after conditioning restored contextual fear responses in juveniles 7 d after initial training. In juveniles that received reconsolidation sessions, protein kinase M zeta (PKMzeta) increased in the amygdala, but not in the hippocampus. PMID: 27918276
5. PKMzeta, but not PKCiota, knock-down disrupted previously established long-time memory. PKCiota and PKMz have distinct functions in long-term potentiation and memory, with PKMzeta playing a specific role in memory maintenance. PMID: 27498875
6. analysis of MAP2c phosphorylation and regulatory protein 14-3-3zeta-binding sites, which reveals key differences between MAP2c and its homolog Tau PMID: 28258221
7. PKMzeta may not affect the neural circuits underlying spontaneous tasks that are different from aversive tasks PMID: 27076427
8. The results of this study found that PKMzeta overexpression in the PrL but not IL enhanced the formation of fear memory, and PKMzeta in the PrL may contribute to the formation of long-term fear memory PMID: 25722116
9. PKCzeta expression is elevated in hepatocytes of insulin resistant ZF rats. Overexpression in primary hepatocytes impairs insulin signal transduction, and in turn, the down-stream insulin-regulated gene expression. PMID: 25822413
10. PKC zeta interacts with LEI/L-DNase II and controls its DNase activity by impairing its nuclear translocation. PMID: 25781645
11. IL-6 activates PI3K and PKCzeta signaling and determines cardiac differentiation in rat embryonic H9c2 cells PMID: 26205888
12. downstream effect of dietary PC is to activate PKCzeta PMID: 25713101
13. Physical exercise reduced the REDD1 protein, increased 14-3-3 protein levels and P38MAPK phosphorylation. PMID: 24691733
14. structural and molecular alterations of the outer blood retinal barrier during the time course of diabetes, focusing on PKCzeta PMID: 24312324
15. Results provide the first evidence that KIBRA as well as PKMzeta is closely related to reference memory but not working memory in rats PMID: 24141945
16. In hippocampal and cortical pyramidal cells, PKMzeta expression is predominantly somatodendritic, and electron microscopy highlights the kinase at postsynaptic densities and in clusters within spines. PMID: 24298142
17. KIBRA levels in the rodent hippocampus correlate closely both to spatial memory performance in rodents and to PKMzeta PMID: 24117625
18. These results suggest that PKMzeta is involved in regulation of dendritic spine structure and function, which may underlie its role in long-term synaptic and behavioral plasticity PMID: 22123937
19. PKMzeta-dependent amplification contributes to nerve injury-induced aversiveness within the rostral anterior cingulate cortex. PMID: 22482911
20. Data demonstrated that 14-3-3tau enhances the transcriptional activity of PR-B. PMID: 22967481
21. Acute intrahippocampal PKMzeta inhibition disrupts place-cell activity in a familiar environment, where the map should be stable. Synaptic plasticity maintained by PKMzeta, which stabilizes the map, is needed for the proper spatial memory expression. PMID: 23035087
22. These data contribute to a growing body of literature that demonstrates that PKMzeta plays a key role in maintaining amygdala-dependent memory. PMID: 22659643
23. EMAP-II induces blood tumor barrier opening via the RhoA/Rho kinase/PKC-alpha/beta signaling pathways, however, PKC-zeta is involved in this process by other mechanisms. PMID: 22531886
24. It was concluded that sevoflurane induces activation of the mTOR pathway, increasing the new protein synthesis of PKMzeta, which is constitutively phosphorylated to its active form, leading to an increased KATP channel-induced hyperpolarizaton. PMID: 22674720
25. PKMzeta in the basolateral amygdala is required for maintenance of associative morphine reward memory; in the infralimbic cortex PKMzeta is required for the maintenance of extinction memory reward-related cues and morphine withdrawal-related aversive cues. PMID: 21633338
26. results suggest that persistent activity of PKMzeta is a requisite for cocaine-induced enhancement of synaptic plasticity in the ventral tegmental area and cocaine conditioned place preference. PMID: 22153887
27. results suggest that PKCzeta, especially PKMzeta isoform, is a significant factor involved in spinal persistent nociceptive processing, specifically, the manifestation of chronic pain states following peripheral inflammation. PMID: 22054645
28. These results suggest spinal PKMzeta is essential for the maintenance of persistent pain by sustaining spinal nociceptive plasticity. PMID: 22185613
29. inhibition of the atypical protein kinase C isoform PKCzeta and its constitutively active isoform PKMzeta with inhibitor ZIP administered locally into the nucleus accumbens core reversibly inhibited the retrieval of drug-associated memory PMID: 22348011
30. This review discusses PKMzeta as necessary and sufficient for the maintenance of long-term potentiation and neuroplasticity in rat sensorimotor cortices. PMID: 21949908
31. PKMzeta is unlikely to be the mediator of synaptic plasticity or memory. PMID: 22378786
32. These results demonstrate that NGF leads to the activation of PKMzeta that ultimately enhances the capacity of small-diameter capsaicin-sensitive sensory neurons to fire APs through a PI3K-dependent signaling cascade. PMID: 21975456
33. Dvl-aPKC interaction can promote axon differentiation mediated by the PAR3-PAR6-aPKC complex. PMID: 17558396
34. Superoxide, PKC-zeta, and PP2A are involved in the hypoxia-induced increase in electrical conductance and occludin reduction at the plasma membrane in alveolar epithelial cells. PMID: 21257729
35. These results suggest that PKMzeta inhibition does not erase memory, but temporarily disrupts expression of memory. PMID: 21258326
36. Metaplasticity governs compartmentalization of synaptic tagging and capture through brain-derived neurotrophic factor (BDNF) and protein kinase Mzeta (PKMzeta). PMID: 21248226
37. study reports that overexpression in the neocortex of the protein kinase C isozyme protein kinase Mzeta (PKMzeta) enhances long-term memory, whereas a dominant negative PKMzeta disrupts memory, even long after memory has been formed PMID: 21385716
38. Src kinase plays an important role in AngII-elicited PKCzeta activation and the subsequent downstream signaling including ERK1/2 activation and VSMCs proliferation. PMID: 20307614
39. the dorsal hippocampus mediates long-term memory for where, but not what things have been encountered, and that PKMzeta maintains this type of spatial knowledge as long as the memory exists. PMID: 19806657
40. This study indicated that PKMzeta maintains long-term memory by regulating the trafficking of GluR2-containing AMPA receptors, the postsynaptic expression of which directly predicts memory retention. PMID: 20383136
41. Translocation of PKCzeta may play a central role in the development of type 2 diabetes. PMID: 20013954
42. Results show that although hypothalamic aPKC signaling is not required for food intake inhibition by insulin or leptin, it plays a key role in inflammatory anorexia and fever induced by LPS. PMID: 19819945
43. Data show that the migration associated control of JNK by aPKCs determines JNK phosphorylation of the plasma membrane substrate paxillin. PMID: 19885391
44. insulin-induced glucose uptake is mainly mediated by PI 3-kinase-PKCzeta signaling, whereas phorbol ester-induced glucose uptake is mainly mediated by conventional PKC despite PI 3-kinase and PKCzeta activations PMID: 11699875
45. Alteration of protein kinase C isoforms in the liver of septic rat. PMID: 11795668
46. 1alpha,25(OH)2D3 regulates chondrocyte matrix vesicle protein kinase C (PKC) directly via G-protein-dependent mechanisms and indirectly via incorporation of PKC during matrix vesicle biogenesis PMID: 11805100
47. Protein kinase C-zeta phosphorylates insulin-responsive aminopeptidase in vitro at Ser-80 and Ser-91. PMID: 12061804
48. Fatty acid infusion impairs insulin stimulated PKC activation PMID: 12095990
49. role in regulating transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-alpha in glioma cells via NF-kappa B PMID: 12130632
50. PLCgamma participates in insulin stimulation of glucose uptake through activation of PKCzeta in brown adipocytes. PMID: 12169270

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KEGG: rno:25522

STRING: 10116.ENSRNOP00000021285

UniGene: Rn.1109