Recombinant Rat Retinol-binding protein 4 (Rbp4)

Code CSB-YP019483RA
MSDS
Size Pls inquire
Source Yeast
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Code CSB-EP019483RA-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP019483RA
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP019483RA
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Rbp4
Uniprot No.
Alternative Names
Rbp4; Retinol-binding protein 4; Plasma retinol-binding protein; PRBP; RBP
Species
Rattus norvegicus (Rat)
Expression Region
19-201
Target Protein Sequence
ER DCRVSSFRVK ENFDKARFSG LWYAIAKKDP EGLFLQDNII AEFSVDEKGH MSATAKGRVR LLSNWEVCAD MVGTFTDTED PAKFKMKYWG VASFLQRGND DHWIIDTDYD TFALQYSCRL QNLDGTCADS YSFVFSRDPN GLTPETRRLV RQRQEELCLE RQYRWIEHNG YCQSRPSRNS L
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.
Gene References into Functions
  1. RBP4 levels increased by 2-fold in the serum of nonobese Goto-Kakizaki rats but not high-fat diet fed rats. PMID: 26923513
  2. plasma RBP4 concentrations were associated with cardiovascular disease. In addition, RBP4 increases the proliferation of vascular smooth muscle cells induced by hyperinsulinism via activation of MAPK signaling pathway PMID: 24888764
  3. Retinol binding protein 4 promotes hyperinsulinisminduced proliferation of rat aortic smooth muscle cells. PMID: 24604418
  4. Decreased trophoblast expression of retinol transport proteins suggest that nitrofen may interfere with the fetal retinol transport resulting in reduced pulmonary RBP and TTR levels and causing pulmonary hypoplasia in CDH. PMID: 22015466
  5. Steatotic liver grafts are more predisposed to down-regulate retinol-binding protein 4 and overexpress proliferator-activated receptor-gamma. PMID: 21487070
  6. RBP4 contributes to the pathogenesis of insulin resistance in spontaneously hypertensive rats. PMID: 21365528
  7. Increases in RBP4 or Nampt/visfatin do not accompany obesity and insulin resistance in the models examined. PMID: 18401839

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Subcellular Location
Secreted.
Protein Families
Calycin superfamily, Lipocalin family
Tissue Specificity
Detected in blood plasma (at protein level).
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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