Recombinant Rat Sclerostin(Sost)

Product Type Recombinant Protein
Uniprot No. Q99P67
Abbreviation Sost
Species Rattus norvegicus (Rat)
Gene Names Sost
Protein Names Recommended name: Sclerostin
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target Details Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
HGNC 13771
RGD 69358
MGI 1921749
Function Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
Subcellular Location Secreted
Protein Families Sclerostin family
Database Links

KEGG: rno:80722

STRING: 10116.ENSRNOP00000028238

UniGene: Rn.95369

Pathway Wnt signaling pathway

Product Details for Different Expression Systems

Product Name Recombinant Rat Sclerostin(Sost),Yeast
Code CSB-YP859165RA
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence FK NDATEIIPGL REYPEPPQEL ENNQTMNRAE NGGRPPHHPY DTKDVSEYSC RELHYTRFVT DGPCRSAKPV TELVCSGQCG PARLLPNAIG RVKWWRPNGP DFRCIPDRYR AQRVQLLCPG GAAPRSRKVR LVASCKCKRL TRFHNQSELK DFGPETARPQ KGRKPRPRAR GAKANQAELE NAY
Expression Region 29-213
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Rat Sclerostin(Sost),Baculovirus
Code CSB-BP859165RA
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence FK NDATEIIPGL REYPEPPQEL ENNQTMNRAE NGGRPPHHPY DTKDVSEYSC RELHYTRFVT DGPCRSAKPV TELVCSGQCG PARLLPNAIG RVKWWRPNGP DFRCIPDRYR AQRVQLLCPG GAAPRSRKVR LVASCKCKRL TRFHNQSELK DFGPETARPQ KGRKPRPRAR GAKANQAELE NAY
Expression Region 29-213
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Rat Sclerostin(Sost),Mammalian cell
Code CSB-MP859165RA
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence FK NDATEIIPGL REYPEPPQEL ENNQTMNRAE NGGRPPHHPY DTKDVSEYSC RELHYTRFVT DGPCRSAKPV TELVCSGQCG PARLLPNAIG RVKWWRPNGP DFRCIPDRYR AQRVQLLCPG GAAPRSRKVR LVASCKCKRL TRFHNQSELK DFGPETARPQ KGRKPRPRAR GAKANQAELE NAY
Expression Region 29-213
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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