Recombinant Rat Sodium-coupled neutral amino acid transporter 2 (Slc38a2), partial

1. Treatment with glutamine and its combination with liraglutide significantly increased pancreatic expression of SNAT2 by approximately 30-35 folds. PMID: 29475006
2. results show that SNAT2 contains 11 transmembrane domains (TMDs) with an intracellular N terminus and an extracellular C terminus PMID: 29678469
3. there is a disulfide bond between Cys245 and Cys279 in SNAT2 which has no effect on cell surface trafficking, as well as transporter function PMID: 27355203
4. These results suggested that Astragalus polysacchrides could improve muscle wasting through Akt/mTOR, ubiquitin proteasome and autophagy signalling, and SLC38A2 may be one of potential targets. PMID: 27049295
5. The results suggest an important role of glutamine transport via SNAT2 in dendritic cells migration and a possible interaction between SNAT2 and CXCR4, by which Toxoplasma gondii manipulates host cell motility. PMID: 25299045
6. Prolactin actively supports lactation providing amino acids to the gland through SNAT2 for the synthesis of milk proteins. PMID: 25701231
7. Determination of SNAT2 mRNA levels by real-time PCR may be useful for estimating wound age. PMID: 24045877
8. The mechanism by which 17beta-estradiol regulates the transcription of SNAT2, was elucidated. PMID: 25056967
9. Sodium-coupled neutral amino acid transporter 2 (SNAT2) mRNA was also induced by the exercise in three muscles PMID: 24016666
10. Data reveal that SNAT2 mRNA and protein expression is higher during embryogenesis, while it subsequently diminishes during postnatal development. PMID: 21718781
11. the cAMP response elements site located at -48 bp was fully responsible for SNAT2 regulation by cAMP PMID: 21386061
12. The C-terminal domain of the neutral amino acid transporter SNAT2 regulates transport activity through voltage-dependent processes PMID: 21158741
13. Insulin promotes the cell surface recruitment of the SAT2/ATA2 system A amino acid transporter from an endosomal compartment in skeletal muscle cells. PMID: 11834730
14. SNAT2 is expressed widely in the CNS, it is enriched in the spinal cord and the brainstem nuclei, especially those of the auditory system. PMID: 15561425
15. Immunohistochemistry demonstrates the presence of SNAT1 and 2 within the placental labyrinth at both days 14 and 20. PMID: 16023720
16. pH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity allosteric regulation involves a conserved histidine residue PMID: 16629640
17. SNAT2 gene is regulated by multiple pathways, indicating that the expression of this amino acid transport system is tightly controlled due to its importance for the mammary gland during pregnancy and lactation PMID: 16787963
18. Placental amino acid transport (SNAT2) is down-regulated prior to the development of Intrauterine growth restriction (IUGR), suggesting that these placental transport changes are a cause, rather than a consequence, of IUGR. PMID: 16916910
19. Our findings support a role for glutamine transport through SNAT1 and/or SNAT2 in the maintenance of abnormal activity in this in vitro model of epileptogenesis. PMID: 17070687
20. SNAT2 may determine intracellular anabolic amino acid levels, regulating the amino acid signaling that affects protein mass, nucleotide/nucleic acid metabolism, and cell growth. PMID: 17429052
21. These results demonstrate a direct or indirect involvement of Asn(82) in Na(+) coordination by SNAT2. PMID: 18319257
22. the mechanisms of upregulation of system A activity by insulin, osmotic shock and amino acid deprivation are different in L6 cells PMID: 18330498
23. Our results suggest that the osmoadaptation of brain oligodendrocytes to hypertonicity relies upon amino-acid accumulation through the tonicity-induced expression of SNAT2. PMID: 18358621

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KEGG: rno:29642

STRING: 10116.ENSRNOP00000031532

UniGene: Rn.16393