Recombinant Rat Synaptosomal-associated protein 25 (Snap25)

1. This study reveals a critical role for the axonal synthesis of SNAP25 in the assembly of presynaptic terminals. PMID: 28954226
2. analysis of crystal structures and biochemical analyses of Rabphilin-3A C2B-SNAP25 and C2B-phosphatidylinositol 4,5-bisphosphate (PIP2) complexes, revealing how Rabphilin-3A C2 domains operate in cooperation with PIP2/Ca(2+) and SNAP25 to bind the plasma membrane, adopting a conformation compatible to interact with the complete SNARE complex PMID: 28634303
3. Our study uncovers the postsynaptic function of the SNAP25-VAMP1-syntaxin4 complex in mediating the constitutive exocytosis of NMDA receptors, suggesting that this SNARE complex is involved in excitatory synaptic transmission PMID: 27791016
4. Findings indicate that lower SNAP-25 in ventromedial caudate in schizophrenia is primarily due to less SNAP-25A, and that the remaining SNAP-25 is associated with greater protein-protein interaction with syntaxin. The absence of a link to recent treatment effects in the human samples, or to administration of antipsychotic drugs in rats suggests the findings are illness- and not treatment-related. PMID: 26971072
5. Electrostatic anchoring precedes stable membrane attachment of SNAP25 and SNAP23 to the plasma membrane. PMID: 28240595
6. Data suggest that GTP-binding protein beta/gamma (Gb/g) heterodimers interact specifically with lipid-embedded neuronal t-SNARE proteins syntaxin 1A and SNAP-25B (synaptosomal-associated protein 25B); this binding is competitive with synaptotagmin 1 for binding sites on the t-SNARE proteins; Gb/g inhibits Ca2+/synaptotagmin 1-dependent membrane fusion. PMID: 28515322
7. Our results will provide novel evidence to reveal the possible role of SNAP-25 in B[a]P-induced neurotoxicity and may be helpful for searching the potential strategy for the prevention measures against B[a]P neurotoxicity. PMID: 28412278
8. directions of changes in the SNAP-25 protein levels in cerebellar granule cells induced by tetrabromobisphenol-A, thalidomide and valproic acid were consistent with the direction of changes in the mRNA level PMID: 27693314
9. TNFalpha induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion. PMID: 26888187
10. Data demonstrate that the open-closed syntaxin equilibrium is shifted toward the open state when syntaxin and Munc18-1 are associated with SNAP25, and the results indicate that a syntaxin/SNAP25:Munc18-1 complex is a likely starting point for SNARE assembly. PMID: 26876096
11. The SNAP-25 in the insular cortex as a part of pathophysiological process that determines predisposition of Krushinsky-Molodkina rats to audiogenic seizures. PMID: 26923581
12. SNAP25 plays a crucial role in sensory functional recovery following spinal cord injury PMID: 24519330
13. protein is mostly important in tissues outside the brain. Our developmental data showed a low expression of Snap25 during fetal life with a sharp increase in the expression of Snap25 just after birth, between postnatal day 2 and 6. PMID: 23135794
14. SNAP-25 facilitated vesicle mobilization to the readily releasable pool, most likely via their roles in endocytosis and/or exocytosis. PMID: 23643538
15. Reduced SNAP-25 alters short-term plasticity at developing glutamatergic synapses. PMID: 23732542
16. The results of this study provided the first evidence showing the dual role of SNAP25 and synaptobrevin in both exocytosis and slow endocytosis at conventional synapses. PMID: 23699527
17. syntaxin 1 and SNAP-25 cooperate as SNARE proteins to support neuron survival. PMID: 23403573
18. These results provide direct experimental support for the availability, in a subpopulation of SNAP-25, of vicinal thiols that may confer on one or more isoforms of this family of proteins a sensitivity to oxidative stress. PMID: 21850520
19. PRIP is involved in the regulation of the phospho-states of SNAP-25 by modulating the activity of PP1, thus regulating exocytosis. PMID: 22311984
20. AC6-mediated inhibition of neurite outgrowth was reversed by the overexpression of Snap25 or a Snapin mutant that could not be phosphorylated. PMID: 21986494
21. endogenous SNAP-25 plays an important role in P/Q-type channel regulation in glutamatergic neurons. PMID: 21558797
22. Letter: incubation of pancreatic islets with fibronectin improves beta cell function via increased expression of syntaxin 1 and SNAP25. PMID: 21926557
23. Data show that the C-terminus of SNAP-25 is a binding target for Gbetagamma necessary for both transient transmitter-mediated presynaptic inhibition, and the induction of presynaptic LTD. PMID: 21633701
24. Palmitoylation determines the precise intracellular distribution of SNAP25. PMID: 21429935
25. SNAP25 was upregulated in frontal cortex but downregulated in caudate putamen. PMID: 20945070
26. There was a more than 10-fold excess of SNAP-25 over syntaxin-1. PMID: 21076040
27. In the incisor dental pulp, all nerve fibers display immunoreactivity for syntaxin-1, SNAP-25, and vesicle-associated membrane protein (VAMP)-2. PMID: 20186959
28. endogenous SNAP-25 regulates native voltage-gated calcium channels in glutamatergic neurons PMID: 20522554
29. SNAP23 and SNAP25 palmitoylation is regulated by DHHC palmitoyl transferases PMID: 20519516
30. Synaptobrevin N-terminally bound to syntaxin-SNAP-25 defines the primed vesicle state in regulated exocytosis. PMID: 20142423
31. This study suggested that overactivity of SNAP-25 in late adolescent-adult brain reduces the signal-to-noise ratio and potential for synaptic plasticity within circuitry controlling spatial and fear memory consolidation resulting in cognitive deficits. PMID: 20002519
32. In conclusion, the preferential localization of SNAP25 in specific synaptic boutons suggests a correlation between SNAP25 and the Pr. This evidence supports the hypothesis that SNAP25 has a modulatory role in shaping synaptic responses. PMID: 19735702
33. binding and inhibition of delayed rectivier potassium channels in secretory cells PMID: 11925439
34. although SNAP-25 phosphorylation at Ser(187) occurs in insulin-secreting cells and is mediated by PKC, it does not appear to play a major role in regulated insulin secretion. PMID: 12164783
35. Hypophysectomy increased adrenal SNAP-25. Corticosterone did not change levels of SNAP-25, but thyroid hormone decreased adrenal SNAP-25, demonstrating the potential importance of the pituitary-thyroid axis. PMID: 12165670
36. Expression of SNAP-25 and syntaxin-1 in adenohypophyses of hypothyroidism. Thyroidectomy changes expression and immunoreactivity of SNAP-25 and syntaxin-1 in adenohypophysis. These effects can be reversed by T4 administration. PMID: 12398231
37. a SNAP-25 mutant can reconstitute exocytosis in BoNT/E-treated cells [review] PMID: 12438121
38. synaptosome-associated protein of 25 kDa and vesicle-associated membrane protein are involved in secretion of polypeptides from the choroid plexus epithelium. PMID: 12559091
39. the syntaxin/SNAP-25 dimer binding to synaptotagmins I and II is mediated by an evolutionarily conserved motif PMID: 14709554
40. Exogenous expression of SNAP-25 in GABAergic interneurons lowered calcium responsiveness, and SNAP-25 silencing in glutamatergic neurons increased calcium elevations evoked by depolarization. PMID: 14980208
41. chronic morphine treatment inhibits phosphorylation of SNAP-25 at Ser187 and leads to a down-regulation of SNARE complex formation PMID: 15277518
42. the results of this study suggest that SNAP-25 in the CA1 region is involved in memory consolidation. PMID: 15355326
43. Results suggest that SNAP-25 protein is involved in axon outgrowth and synaptogenesis in the nervous system. PMID: 15478103
44. different raft-targeting signals within SNAP-25 and SNAP-23 are likely important for fine-tuning the exocytic pathways in which these proteins operate PMID: 15542596
45. Correlation between the number of SNAP-25 clusters and the number of docked insulin granules, which is associated with the fusion of insulin granules. PMID: 15647897
46. However, effects of diazoxide on SNAP-25 protein were nullified by proteasome inhibitors (ALLN, MG-132, and epoxomicin) but not by lysosomal inhibition (NH(4)Cl). PMID: 15752769
47. The binding of multiple syntaxins to SNAP-25 in PC12 cells is reported. PMID: 15975093
48. These results indicate that phospholipase A(2)-IIA is coexpressed with SNAP-25 in mature taste receptor cells that possess exocytotic machinery. PMID: 16385482
49. We conclude that different domains within SNAP-25 can form distinct complexes with Kv2.1 to execute a fine allosteric regulation of channel gating and the architecture of the outer pore structure in order to modulate cell excitability. PMID: 16478442
50. Treatment with botulinum neurotoxins A and B strongly reduced somatodendritic dopamine release, thus demonstrating the requirement for SNARE proteins SNAP-25 and synaptobrevin. PMID: 16539689

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KEGG: rno:25012

UniGene: Rn.107689