Recombinant Rat Tartrate-resistant acid phosphatase type 5 (Acp5)

Code CSB-YP001178RA
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Source Yeast
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Code CSB-EP001178RA
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Source E.coli
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Code CSB-EP001178RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP001178RA
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Source Baculovirus
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Code CSB-MP001178RA
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Acp5; Tartrate-resistant acid phosphatase type 5; TR-AP; EC; Tartrate-resistant acid ATPase; TrATPase; Type 5 acid phosphatase
Rattus norvegicus (Rat)
Expression Region
Target Protein Sequence
Protein Length
Full Length of Mature Protein
Tag Info
The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates.
Gene References into Functions
  1. increased osteoclast activity does not affect TRAP expression in osteoblasts and osteocytes PMID: 24395179
  2. Polyphosphate may play an important regulatory role in osteoclastic bone resorption by inhibiting TRAP activity. PMID: 24223830
  3. Data indicate that tartrate-resistant acid phosphatase 5b levels treated with cadmium and fluoride or in combination were 1-2.5 folds higher than the control. PMID: 23868496
  4. induction of TRAP provides an early sign of macrophage responsiveness in DSS induced colitis PMID: 19821118
  5. This study demonstrates that adhesion of isolated neonatal rat osteoclasts in vitro was augmented on bovine milk osteopontin (bmOPN) with post-translational modifications (PTMs) compared to human Escherichia-coli-derived recombinant OPN without PTMs. PMID: 19854170
  6. This enzyme is a useful serum marker for bone metastases in breast cancer patients. PMID: 12820340
  7. TRAP enzyme has a rapid turnover in osteoclasts and uses a transcytotic pathway PMID: 14696961
  8. The co-localization of PAP/TRAP and the cysteine protease cathepsin L could suggest a role for cathepsin L in the in vivo proteolytic processing of PAP/TRAP. proteolytic processing of PAP/TRAP PMID: 15761664
  9. Cathepsin K co-localized with TRAP in osteoclast-resorptive compartments, supporting a role for cathepsin K in the extracellular processing of monomeric TRAP in the resorption lacuna. PMID: 15929988
  10. insulin-dependent diabetes mellitus contributes to bone loss through changes in gene expression of TRAP and cathepsin K in osteoclasts as well as osteocalcin in osteoblasts PMID: 17916452

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Subcellular Location
Tissue Specificity
Characteristic constituent of osteoclasts and some mononuclear preosteoclasts. Preferentially expressed in skeletal tissues.
Database Links
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