Recombinant Rat Transferrin receptor protein 1(Tfrc)

Code CSB-YP858708RA
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Source Yeast
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Code CSB-EP858708RA
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Source E.coli
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Code CSB-EP858708RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP858708RA
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Source Baculovirus
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Code CSB-MP858708RA
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Tfrc
Uniprot No. Q99376
Alternative Names Tfrc; Trfr; Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; CD antigen CD71; Fragment
Species Rattus norvegicus (Rat)
Expression Region 1-622
Target Protein Sequence IEFTDIIKQL SQNTYTPREA GSQKDENLAY YIENLFHDFK FSKVWRDEHY VKIQVKNSVS QNLVTINSGS NIDPVEAPEG YVAFSKAGEV TGKLVHANFG TKKDFEELNY SVNGSLVIVR AGKITFAEKV ANAQSFNAIG VLIYMDRNTF PVVEADLQFF GHAHLGTGDP YTPGFPSFNH TQFPPSQSSG LPSIPVQTIS RAPAEKLFKN MEGNCPPSWN IDSSCKLELS QNQNVKLTVN NVLKETRILN IFGVIKGYEE PDRYIVVGAQ RDAWGPGVAK SSVGTGLLLK LAQVFSDMIS KDGFRPSRSI IFASWTAGDY GAVGPTEWLE GYLSSLHLKA FTYINLDKVV LGTSNFKVSA SPLLYTLMGK IMQDVKHPID GKYLYRNSNW ISKIEELSLD NAAFPFLAYS GIPAVSFCFC EDEDYPYLGT KLDTYEILIQ KVPQLNQMVR TAAEVAGQFI IKLTHDIELT LDYEMYNSKL LSFMKDLNQF KADIKDMGLS LQWLYSARGD YFRATSRLTT DFHNAEKTNR FVMREINDRI MKVEYHFLSP YVSPRESPFR HIFWGSGSHT LSALVENLRL RQKNITAFNE TLFRNQLALA TWTIQGVANA LSGDIWNIDN EF
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity).
Subcellular Location Cell membrane, Single-pass type II membrane protein, Melanosome
Protein Families Peptidase M28 family, M28B subfamily
Tissue Specificity In testis, expressed in Sertoli cells, peritubular myoid cells and in germinal cells. Highest levels in Sertoli cells.
Database Links

STRING: 10116.ENSRNOP00000002407

UniGene: Rn.98672

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