TFRC

TFRC, which stands for Transferrin Receptor Protein 1, is a transferrin receptor protein. It is located on the cell membrane and primarily regulates cellular uptake of iron elements. It accomplishes this by binding to free iron and transporting it into cells and tissues through circulation. Once transferrin binds to free iron to form a transferrin-iron complex, it interacts with TFRC on the cell surface. The main function of TFRC is to facilitate the internalization of the transferrin-iron complex through endocytosis, meeting the cell's iron demands and thereby sustaining cell growth and metabolism. Given its significant role in cell growth and differentiation, some drug delivery systems utilize TFRC's expression on the cell membrane to enhance the intracellular transport and targeting efficacy of therapeutic drugs. As a result, TFRC has emerged as a potential target for drug delivery and treatment.

More Interesting read related TFRC: a Stimulator of Fe Transport Affects Anemia, Neurodegenerative Disorders and Cancers!

Popular Product

● Recombinant Human Transferrin receptor protein 1(TFRC),partial (Active) CSB-MP3648HU

Validated Data

High Purity Validated by SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TFRC at 2μg/mL can bind Anti-TFRC recombinant antibody (CSB-RA023441MA1HU), the EC₅₀ is 3.305-8.220 ng/mL.

● TFRC Recombinant Monoclonal Antibody CSB-RA023441MA1HU

Validated Data

ELISA

The Binding Activity of Human TFRC with Anti-TFRC Recombinant Antibody

Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TFRC (CSB-MP3648HU) at 2 μg/mL can bind Anti-TFRC recombinant antibody , the EC₅₀ is 3.305-8.220 ng/mL