TFRC

TFRC, transferrin receptor, also known as CD71, TFR1, p90. TFRC encoded by the human TFRC gene, is a type II transmembrane protein that exists as a homodimer on the cell surface and is essential for cell growth.
The mechanism of action of TFRC includes interaction with transferrin to mediate iron uptake, and under normal physiological conditions, iron bound to transferrin is the major form of iron present in the blood.TFRC also extensively regulates the expression of genes related to ion transport and immunity, and is involved in the progression of cervical cancer by affecting gene expression and alternative splicing in HeLa cells, suggesting that TFRC may have a broad regulatory function.
TFRC is highly expressed in a variety of tumors and is associated with tumorigenesis, invasion and metastasis, making it an important oncogene. The degree of TFRC expression correlates with the malignancy of the disease, and its overexpression promotes tumor cell growth, proliferation and metastasis, making it a novel target for the development of antibody-coupled drugs.