TFRC, transferrin receptor, also known as CD71, TFR1, p90. TFRC encoded by the human TFRC gene, is a type II transmembrane protein that exists as a homodimer on the cell surface and is essential for cell growth.
The mechanism of action of TFRC includes interaction with transferrin to mediate iron uptake, and under normal physiological conditions, iron bound to transferrin is the major form of iron present in the blood.TFRC also extensively regulates the expression of genes related to ion transport and immunity, and is involved in the progression of cervical cancer by affecting gene expression and alternative splicing in HeLa cells, suggesting that TFRC may have a broad regulatory function.
TFRC is highly expressed in a variety of tumors and is associated with tumorigenesis, invasion and metastasis, making it an important oncogene. The degree of TFRC expression correlates with the malignancy of the disease, and its overexpression promotes tumor cell growth, proliferation and metastasis, making it a novel target for the development of antibody-coupled drugs.
Recombinant Human Transferrin receptor protein 1 (TFRC), partial (Active) (CSB-MP3648HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TFRC at 2μg/mL can bind Anti-TFRC recombinant antibody (CSB-RA023441MA1HU), the EC50 is 3.305-8.220 ng/mL.
Validated Data
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA104885(TFRC Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA104885(TFRC Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 231 cells, Jurkat cells, Primary antibody: CSB-PA104885(TFRC Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
The following TFRC reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
TFRC Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA023441GA01HU | TFRC Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA07219B0Rb | TFRC Antibody, HRP conjugated | Human | ELISA |
CSB-PA07219D0Rb | TFRC Antibody, Biotin conjugated | Human | ELISA |
CSB-PA07219A0Rb | TFRC Antibody | Human | ELISA, WB, IHC, IF |
CSB-PA001477 | TFRC Antibody | Human,Mouse | WB, IHC, ELISA |
CSB-PA005607 | TFRC Antibody | Human | WB, ELISA |
CSB-PA010092 | Phospho-TFRC (S24) Antibody | Human,Mouse | WB, IHC, ELISA |
CSB-PA104885 | TFRC Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA834425 | TFRC Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-RA023441MA1HU | TFRC Recombinant Monoclonal Antibody | Human | ELISA |
TFRC Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA726792ZA01MO | Tfrc Antibody | Mus musculus | ELISA, WB (ensure identification of antigen) |
TFRC Proteins for Equus caballus (Horse)
Code | Product Name | Source |
---|---|---|
CSB-YP651210HO CSB-EP651210HO CSB-BP651210HO CSB-MP651210HO CSB-EP651210HO-B |
Recombinant Horse Transferrin receptor protein 1 (TFRC), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TFRC Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Code | Product Name | Source |
---|---|---|
CSB-YP719275PYX CSB-EP719275PYX CSB-BP719275PYX CSB-MP719275PYX CSB-EP719275PYX-B |
Recombinant Pongo abelii Transferrin receptor protein 1 (TFRC), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TFRC Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP726792MO CSB-BP726792MO CSB-MP726792MO CSB-EP726792MO-B |
Recombinant Mouse Transferrin receptor protein 1 (Tfrc), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TFRC Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP816838PI CSB-BP816838PI CSB-MP816838PI CSB-EP816838PI-B |
Recombinant Pig Transferrin receptor protein 1 (TFRC), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TFRC Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-YP856194CH CSB-EP856194CH CSB-BP856194CH CSB-MP856194CH CSB-EP856194CH-B |
Recombinant Chicken Transferrin receptor protein 1 (TFRC), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TFRC Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP858708RA1 CSB-BP858708RA1 CSB-MP858708RA1 CSB-EP858708RA1-B |
Recombinant Rat Transferrin receptor protein 1 (Tfrc), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TFRC Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
Code | Product Name | Source |
---|---|---|
CSB-YP867082DO CSB-EP867082DO CSB-BP867082DO CSB-MP867082DO CSB-EP867082DO-B |
Recombinant Dog Transferrin receptor protein 1 (TFRC), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TFRC Proteins for Felis catus (Cat) (Felis silvestris catus)
Code | Product Name | Source |
---|---|---|
CSB-YP882000CA CSB-EP882000CA CSB-BP882000CA CSB-MP882000CA CSB-EP882000CA-B |
Recombinant Cat Transferrin receptor protein 1 (TFRC), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TFRC Proteins for Mus musculus(Mouse)
Code | Product Name | Source |
---|---|---|
CSB-EP726792MO | Recombinant Mouse Transferrin receptor protein 1 (Tfrc), partial | E.coli |
TFRC Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-MP3648HU | Recombinant Human Transferrin receptor protein 1 (TFRC), partial (Active) | Mammalian cell |
TFRC ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E08389m | Mouse transferrin receptor,TFR ELISA Kit | serum, plasma, tissue homogenates | 0.156 ng/mL |
TFRC ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E09100h | Human soluble transferrin receptor,sTfR ELISA Kit | serum, plasma | Request Information |