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Recombinant Sheep Gonadotropin-releasing hormone receptor (GNRHR), partial

Recombinant Sheep Gonadotropin-releasing hormone receptor (GNRHR), partial

Code	CSB-YP009637SH1
MSDS	MSDS
Size	Pls inquire
Source	Yeast
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Code	CSB-EP009637SH1
MSDS	MSDS
Size	Pls inquire
Source	E.coli
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Code	CSB-EP009637SH1-B
MSDS	MSDS
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP009637SH1
MSDS	MSDS
Size	Pls inquire
Source	Baculovirus
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Code	CSB-MP009637SH1
MSDS	MSDS
Size	Pls inquire
Source	Mammalian cell
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

GNRHR

Uniprot No.

P32237

Alternative Names

GNRHR; Gonadotropin-releasing hormone receptor; GnRH receptor; GnRH-R

Species

Ovis aries (Sheep)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function

Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.

Gene References into Functions

data suggest that decrease in LH secretion during the long photoperiod in sheep may be due to low translational activity of genes encoding both GnRH and GnRHR. PMID: 27901351
These results suggested that beta-endorphinergic system in the hypothalamus of follicular-phase ewes affects directly or via beta-endorphin-sensitive interneurons GnRH and GnRHR biosynthesis leading to suppression in secretory activity of the hypothalamic-pituitary axis. PMID: 27335238
These results indicate that the disturbances of gonadotropin secretion under stress conditions in sheep may be due to a dysfunction of GnRH and GnRHR biosynthetic pathways. PMID: 27629353
Data indicate that ESR1 on plasma membrane surface is likely candidate for mediating E2 up-regulation of GNRHR expression in pituitary cells; this signaling mechanism proceeds through CREB-dependent pathway. PMID: 21734267
LPS injections decrease GnRH and GnRHR genes expression in brain. PMID: 20427135
Short as well as prolonged stress stimuli caused an increase in GnRH-R mRNA levels in the hypothalamus and pituitary. PMID: 17435833
cortisol acts via the type II glucocorticoid receptor within the pituitary gland to elicit a rapid decrease in responsiveness to GnRH, independent of changes in expression of the GnRH receptor PMID: 17962347
Infusion of sulpiride into the third ventricle increases GnRH mRNA levels in the anterior pituitary gland. PMID: 18528813