Recombinant Zaire ebolavirus Membrane-associated protein VP24 (VP24)

Code CSB-MP522532ZAS
Product Type Recombinant Protein
Size US$1848
Uniprot No. O11459
Storage Buffer Tris-based buffer,50% glycerol
Species Zaire ebolavirus (strain Gabon-94) (ZEBOV) (Zaire Ebola virus)
Purity Greater than 85% as determined by SDS-PAGE.
Sequence MAKATGRYNLISPKKDLEKGVVLSDLCNFLVSQTIQGWKVYWAGIEFDVTHKGMALLHRLKTNDFAPAWSMTRNLFPHLFQNPNSTIESPLWALRVILAAGIQDQLIDQSLIEPLAGALGLISDWLLTTNTNHFNMRTQRVKEQLSLKMLSLIRSNILKFINKLDALHVVNYNGLLSSIEIGTQNHTIIITRTNMGFLVELQEPDKSAMNRKKPGPAKFSLLHESTLKAFTQGSSTRMQSLILEFNSSLAI
Research Area Others
Source Mammalian cell
Gene Names VP24
Protein Names Recommended name: Membrane-associated protein VP24
Expression Region 1-251aa
Tag Info N-terminal 10xHis-tagged and C-terminal Myc-tagged
Mol. Weight 33.2
Protein Description Full Length
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
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Function Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.
Subcellular Location Virion membrane, Peripheral membrane protein, Host cell membrane, Peripheral membrane protein, Cytoplasmic side, Host endomembrane system, Peripheral membrane protein
Protein Families Filoviridae membrane-associated protein VP24 family

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