Recombinant human Transcription initiation factor IIB

1. a hand-off model in which Ssu72 mediates a conformational transition in TFIIB, accounting for the role of Ssu72 in transcription reinitiation, gene looping, and promoter-terminator cross-talk. PMID: 29158257
2. binding of specific DNA sequences changes the protein structure and dynamics, and TFIIB may exist in two conformational states PMID: 26284261
3. The role of zinc at Cys3His1 binding site in the absence of TFIIB protein folding PMID: 26016528
4. these results establish a new paradigm for TFIIB functionality in human gene expression, which when downregulated has potent anti-viral effects. PMID: 24441171
5. Association of the winged helix motif of the TFIIEalpha subunit of TFIIE with either the TFIIEbeta subunit or TFIIB distinguishes its functions in transcription. PMID: 25492609
6. TFIIB was involved in the proliferation and growth of HCC cells. PMID: 23055019
7. a mode of phospho-TFIIB-independent transcriptional regulation that prioritizes the transcription of p53-target genes during cellular stress. PMID: 23115335
8. Data show that TFIIF has an important role in stabilizing TFIIB within the PIC and after transcription initiates. PMID: 21896726
9. a six-amino acid human TFIIB tip region is needed for appropriate levels of serine 5 C-terminal domain phosphorylation and mRNA capping and for retention of the required elongation factor TFIIF. PMID: 20880846
10. phosphorylation of TFIIB at serine 65 is a critical event in transcription that links the gene promoter and terminator and triggers initiation by RNA pol II PMID: 20226668
11. interaction with vitamin D receptor helix H10 residues PMID: 12529369
12. Data show that human TATA box binding protein (TBP) can use a shared surface to interact with two different transcription factor IIB (TFIIB) family members to initiate transcription by different RNA polymerases. PMID: 12535529
13. The groove in the first cyclin repeat of TFIIB is identified as the FCP1-binding site of TFIIB core domain (TFIIBc), consisting of several hydrophobic and several basic amino acids. PMID: 12578358
14. lack of role in bending of TATA-binding protein simultaneously with promotoer DNA PMID: 12791683
15. TFIIB interacts with SP1/SP3 at the SP1 site, besides its association with EAR3 and the TATA-less core promoter region. PMID: 12972613
16. in addition to its role in regulating TBP binding to a TATA box, the TBP surface is unexpectedly involved in TBP association with all three TFIIB family members PMID: 14585974
17. The structural role of Zn2+ binding to the the zinc-ribbon domain of TFIIB was analysed. PMID: 14641108
18. Results identify a small nonconserved surface of the transcription factor TFIIB zinc ribbon that is required for RNA polymerase II (pol II) transcription in vivo and for different types of basal pol II transcription in vitro. PMID: 15024075
19. A TFIIB conformational change is critical for the formation of activator-dependent transcription complexes. PMID: 15037660
20. Collapse of the transcription bubble defines the RNA polymerase II promoter clearance transition. PMID: 15989968
21. high level of TFIIB can bypass the Mediator requirement for basal transcription and pol II recruitment in nuclear extract PMID: 16595664
22. Together, our results support a mode of preinitiation complex assembly in which TFIIB/RNA polymerase II recruitment to the promoter occurs in vivo. PMID: 16878124
23. TFIIB binding is required for the interferon antagonist effect exerted by Thogoto virus M protein. PMID: 18768974
24. slipping at juncture is induced by TATA-binding protein and transcription factor IIB and requires a TATA box but not a transcription factor IIB recognition sequence PMID: 19193635
25. TFIIF in HeLa cell nuclear extract helps to rescue the inactive mutations by interacting with either the B-finger or another component of the initiation complex that is influenced by the B-finger PMID: 19590095

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HGNC: 4648

OMIM: 189963

KEGG: hsa:2959

STRING: 9606.ENSP00000359531

UniGene: Hs.481852