Code | CSB-RA268983A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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WB | 1:500-1:2000 |
The BRIP1 recombinant monoclonal antibody is created using synthetic genes through in vitro methods. This process entails the retrieval of BRIP1 antibody genes from B cells obtained from immunoreactive rabbits, followed by gene amplification and insertion into suitable phage vectors. These vectors are then introduced into mammalian cell lines, enabling the production of functional antibodies in substantial quantities. Subsequently, the BRIP1 recombinant monoclonal antibody is purified from the culture supernatant of the transfected cell lines through affinity chromatography and is suitable for ELISA and WB applications, facilitating the detection of human BRIP1 protein.
BRIP1 is a DNA helicase protein that plays a crucial role in DNA repair processes, particularly in the context of homologous recombination and genome stability maintenance. Its interaction with BRCA1 and involvement in the Fanconi anemia pathway are essential for the repair of DNA damage and the prevention of cancer development. Mutations in BRIP1 can increase the risk of hereditary breast and ovarian cancer.
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