CCR8 Recombinant Monoclonal Antibody

Code CSB-RA004847MA4HU
Size US$210
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  • Untransfected HEK293T cells surface(green line) and transfected Human CCR8 HEK293T stable cells surface (red line) were stained with anti-CCR8 recombinant antibody (2µg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
  • Untransfected CHO-K1 cells surface (green line) and transfected Human CCR8 CHO-K1 stable cells surface (red line) were stained with anti-CCR8 recombinant antibody (2µg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
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Product Details

Uniprot No.
Target Names
Alternative Names
C C chemokine receptor type 8 antibody; C C CKR 8 antibody; C C motif chemokine receptor 8 antibody; C-C chemokine receptor type 8 antibody; C-C CKR-8 antibody; CC chemokine receptor 8 antibody; CC chemokine receptor CHEMR1 antibody; CC chemokine receptor type 8 antibody; CC CKR 8 antibody; CC-CKR-8 antibody; CCR 8 antibody; CCR-8 antibody; Ccr8 antibody; CCR8 protein antibody; CCR8-L antibody; CCR8_HUMAN antibody; CDw198 antibody; CDw198 antigen antibody; Chemokine (C C motif) receptor 8 antibody; Chemokine (C C) receptor 8 antibody; Chemokine (C C) receptor like 2 antibody; Chemokine (CC motif) receptor 8 antibody; Chemokine (CC) receptor 8 antibody; Chemokine (CC) receptor like 1 antibody; Chemokine (CC) receptor like 2 antibody; Chemokine C C motif receptor 8 antibody; Chemokine C C receptor 8 antibody; Chemokine CC motif receptor 8 antibody; Chemokine CC receptor 8 antibody; Chemokine receptor 8 antibody; Chemokine receptor like 1 antibody; Chemokine receptor-like 1 antibody; CKR L1 antibody; CKR-L1 antibody; CKRL 1 antibody; CKRL1 antibody; CMKBR 8 antibody; CMKBR L2 antibody; CMKBR8 antibody; CMKBRL 2 antibody; CMKBRL2 antibody; CY 6 antibody; CY6 antibody; GPR CY6 antibody; GPR-CY6 antibody; GPRCY6 antibody; MGC123958 antibody; MGC123959 antibody; MGC129966 antibody; MGC129973 antibody; TER 1 antibody; TER1 antibody
Species Reactivity
Recombinant Human CCR8 protein
Immunogen Species
Homo sapiens (Human)
hIgG1,lambda 2
Clone No.
Purification Method
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Tested Applications
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

CUSABIO meticulously generated the CCR8 recombinant monoclonal antibody through a systematic procedure. Initially, B cells were extracted from the immunized animal's spleen, employing the recombinant human CCR8 protein as the immunogen during the immunization process. Subsequently, RNA isolation from the B cells was followed by cDNA synthesis through reverse transcription. By utilizing the cDNA as a template, the gene encoding the CCR8 antibody was extended using a degenerate primer and inserted into a recombinant vector. The recombinant vector was then introduced into host cells via transfection, facilitating the expression of the CCR8 recombinant monoclonal antibodies. These antibodies were harvested from the cell culture supernatant and subjected to purification using affinity chromatography. Rigorous validation testing FC was conducted to verify this antibody's reactivity with human CCR8 protein, ensuring its specificity and reliability.

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Target Background

Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
Gene References into Functions
  1. Authors demonstrate the pivotal role of CCR8(+) Treg cells in restraining immunity and highlight the potential clinical implications of this discovery. PMID: 28533380
  2. Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding. PMID: 27226537
  3. High CCR8 expression is associated with high recurrence in kidney cancer. PMID: 26716905
  4. findings suggest that CCR8 expression in ALCL is more closely related to the presence of DUSP22 rearrangements than to cutaneous involvement and that the function of CCR8 may extend beyond its skin-homing properties in this disease PMID: 25390351
  5. Epidermal-derived vitamin D3 metabolites and prostaglandins provide an essential cue for the localization of CCR8+ immune surveillance T cells within healthy human skin. PMID: 26002980
  6. CCL1-CCR8 interaction may play a critical role in lymphocytic recruitment in IgG4-related sclerosing cholangitis and type 1 autoimmune pancreatitis, leading to duct-centred inflammation and obliterative phlebitis. PMID: 23811304
  7. Identification of human CCR8 as a CCL18 receptor. PMID: 23999500
  8. CCR8(+) myeloid cell subset is expanded in patients with cancer. PMID: 23363815
  9. Data show that CCR8 expression by newly activated naive T cells is regulated by skin-specific factor(s) derived primarily from epidermal keratinocytes. PMID: 23043070
  10. C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity PMID: 22479563
  11. The functional data from human macrophages suggest a potential cross talk between the CCR8 and the Toll-like receptor 4 (TLR4) pathways, both of which are present in chronic obstructive pulmonary disease patients. PMID: 21976223
  12. There may be a role for CCR8 in the recruitment of T cells to the lung in asthmatics. PMID: 20455898
  13. CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway PMID: 12525579
  14. found in the central nervous system and is associated with phagocytic macrophages PMID: 12547701
  15. CCR8 genes and surrounding genomic regions these genes are the result of the duplication of an ancestral gene prior to the divergence of teleost fish. PMID: 12551893
  16. Transfected human CCR8-dependent activation of the RAS/MAPK pathway mediates anti-apoptotic activity of I-309/ CCL1 and vMIP-I. PMID: 12645948
  17. The induction of CCR8 under conditions associated with vascular smooth muscle cell proliferation and migration raises the possibility that CCR8 may play an important role in vessel wall pathology. PMID: 14576057
  18. the axis CCL1-CCR8 links adaptive and innate immune functions that play a role in the initiation and amplification of atopic skin inflammation PMID: 15814739
  19. CCR8 ligands are allotropic, binding to distinct sites within CCR8; the human immune system may have evolved to use CCL7 as a selective antagonist of viral chemokine activity at CCR8 but not those of the host ligand PMID: 17023422
  20. CCR8 is expressed by a small and heterogeneous population of peripheral blood CD4 memory T cells enriched in T helper type 2 (Th2) effector and T regulatory (Treg) cells. PMID: 17082609
  21. CCR8-expressing CD4-positive T lymphocytes are preferentially recruited from the periphery into the lungs of asthmatic individuals, driven by elevated CCL1 levels produced almost exclusively by mast cells and basophils. PMID: 17641040
  22. The combination of 17beta-E(2) with the environmental pollutant TCDD is involved in the pathogenesis of endometriosis via up-regulating the chemokine CCR8-I-309. PMID: 17693327

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family
Database Links

HGNC: 1609

OMIM: 601834

KEGG: hsa:1237

STRING: 9606.ENSP00000326432

UniGene: Hs.113222

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