CCR8

CCR8 is a member of the chemokine receptor subfamily and belongs to the G protein-coupled receptors. Human CCL1 is the major ligand for CCR8, and other ligands are CCL8, CCL16 and CCL18. CCR8 is specifically expressed on tumor-infiltrating regulatory T cells (Treg) and is also expressed on both Th2 cells and tumor cells; however, it is largely not expressed on peripheral blood Treg or normal tissues.The main role of CCR8 is to participate in the recruitment of Tregs and Th2 cells to inflammatory and tumor sites. Numerous studies indicated that high expression of CCR8 is associated with a variety of cancers, including colorectal cancer, breast cancer, gastric cancer, metastatic brain cancer, and metastatic liver cancer, especially on Tregs cells isolated from breast cancer. Thus, the CCR8 becomes a significant research target that attracts researchers' attention in recent years.

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Popular Product

Recombinant Human C-C chemokine receptor type 8(CCR8)-VLPs (Active) (CSB-MP004847HU)

Validated Data

Excellent antigen-antibody Binding Bioactivity Validated by Function ELISA

Immobilized human CCR8 at 5 μg/ml can bind Anti-CCR8 recombinant Antibody, the the EC₅₀ is 11.13-17.29 ng/ml.

Structure accuracy detected
by TEM

The presence of VLP-like structures was confirmed by TEM