CCR8, C-C motif chemokine receptor 8, alias CD198, ChemR1, CKRL1, CKR-L1, CY6, GPRCL1, GPRCY6, GPR-CY6, TER-1, etc. CCR8 is a seven-transmembrane G-protein-coupled receptor belonging to the C-C subfamily of chemokine receptors. CCR8 mechanism of action involves binding of CCL1, CCL8, CCL16, and CCL18, with CCL1 being its major ligand. These interactions are involved in the developmental process of various tumors and mediate immune escape from tumors.
CCR8 is specifically highly expressed on regulatory T cells (Treg) mainly in the tumor microenvironment, and is lowly expressed in the surrounding normal tissues and peripheral blood, thus CCR8 can be used as a specific marker for Treg cells and is a promising therapeutic target and biomarker. The high CCR8 expression has been associated with a variety of cancers, including colorectal, breast, and gastric cancers, and is considered to be a potential specific marker for Treg at tumor sites, and a highly promising target for tumor immunity.
Recombinant Human C-C chemokine receptor type 8 (CCR8) (CSB-CF004847HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CCR8 Recombinant Monoclonal Antibody (CSB-RA004847A1HU)
Validated Data
Untransfected HEK293T cells surface (green line) and transfected Human CCR8 HEK293T stable cells surface (red line) were stained with anti-CCR8 antibody (2µg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
CCR8 Recombinant Monoclonal Antibody (CSB-RA004847MA3HU)
Validated Data
Untransfected CHO-K1 cells surface(green line) and transfected Human CCR8 CHO-K1 stable cells surface (red line) were stained with anti-CCR8 antibody (2µg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
The Binding Activity of CCR8 with Anti-CCR8 recombinant antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CCR8 (CSB-MP004847HU) at 5 μg/mL can bind Anti-CCR8 recombinant antibody, the EC50 is 11.20-15.63 ng/mL.
The following CCR8 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
CCR8 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA091770 | CCR8 Antibody | Human | ELISA,WB,IHC |
CSB-PA172806 | CCR8 Antibody | Human | ELISA,WB,IHC |
CSB-RA004847A1HU | CCR8 Recombinant Monoclonal Antibody | Human | FC |
CSB-RA004847MA3HU | CCR8 Recombinant Monoclonal Antibody | Human | ELISA, FC |
CSB-RA004847MA2HU | CCR8 Recombinant Monoclonal Antibody | Human | FC |
CSB-RA004847MA4HU | CCR8 Recombinant Monoclonal Antibody | Human | FC |
CCR8 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF004847MO | Recombinant Mouse C-C chemokine receptor type 8 (Ccr8) | in vitro E.coli expression system |
CSB-YP004847MO1 CSB-EP004847MO1 CSB-BP004847MO1 CSB-MP004847MO1 CSB-EP004847MO1-B |
Recombinant Mouse C-C chemokine receptor type 8 (Ccr8), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-MP004847MO | Recombinant Mouse C-C chemokine receptor type 8 (Ccr8)-VLPs | Mammalian cell |
CCR8 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF004847HU | Recombinant Human C-C chemokine receptor type 8 (CCR8) | in vitro E.coli expression system |
CSB-EP004847HU1 CSB-BP004847HU1 CSB-MP004847HU1 CSB-EP004847HU1-B |
Recombinant Human C-C chemokine receptor type 8 (CCR8), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF004847HU2-N | Recombinant Human C-C chemokine receptor type 8 (CCR8), partial,Nanodiscs | in vitro E.coli expression system |
CSB-CF004847HU2 | Recombinant Human C-C chemokine receptor type 8 (CCR8), partial | in vitro E.coli expression system |
CSB-YP004847HU1 | Recombinant Human C-C chemokine receptor type 8 (CCR8), partial | Yeast |
CSB-MP004847HU | Recombinant Human C-C chemokine receptor type 8 (CCR8)-VLPs (Active) | Mammalian cell |
CCR8 Proteins for Macaca mulatta (Rhesus macaque)
Code | Product Name | Source |
---|---|---|
CSB-CF004847MOW | Recombinant Macaca mulatta C-C chemokine receptor type 8 (CCR8) | in vitro E.coli expression system |
CSB-YP004847MOW1 CSB-EP004847MOW1 CSB-BP004847MOW1 CSB-MP004847MOW1 CSB-EP004847MOW1-B |
Recombinant Macaca mulatta (Rhesus macaque) C-C chemokine receptor type 8 (CCR8), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |