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CD80 is a costimulatory molecule that regulates the activity of both normal and malignant B cells and plays a role in T-cell activation. Surface CD80 is expressed transiently on activated B cells, macrophages, and DCs. Most cancer cells have reduced CD80 levels, and the loss of CD80 alone is enough to allow them to evade the immune system's onslaught and induce anergy and death in tumor-infiltrating T cells. In HIV-infected mice corneas, CD80 plays a significant role in increased inflammatory responses.The production of this recombinant CD80 antibody started with identifying and cloning the genes for antibody expression. After the CD80 antibody was cloned into an expression plasmid, the plasmid could be introduced into the mammalian cell to produce the target recombinant antibody. This recombinant CD80 antibody has been validated in ELISA, WB, IHC, IP.
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