CRTC3 Recombinant Monoclonal Antibody

1. CRTC3-MAML2 gene fusion occurs in hidradenomas. PMID: 29079171
2. CRTC3 polymorphism was associated with the onset of acute coronary syndrome in Han Chinese patients, which may be related to the imbalance of the lipid metabolism PMID: 29979427
3. findings suggest further characterization of MECs is needed before considering the CRTC1/3-MAML2 gene fusion as a prognostic biomarker PMID: 28438292
4. revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions in cutaneous hidradenoma PMID: 27402217
5. The CRTC3 polymorphism rs3862434 is associated with the plasma level of total cholesterol, and rs11635252 is associated with the risks of overweight and hypertriglyceridemia in a Chinese Han population. PMID: 24264430
6. Metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands did not harbor CRTC1-MAML2 and CRTC3-MAML2 fusion transcripts, respectively, or MAML2 gene rearrangement. PMID: 24121173
7. mucoepidermoid carcinoma of the salivary glands positive for CRTC1-MAML2 or CRTC3-MAML2 fusion formed a favourable tumour subset that was distinct from fusion-negative cases PMID: 21668476
8. CRTC3 plays a selective role in mitochondrial biogenesis in response to rotenone PMID: 21536665
9. As a common human CRTC3 variant with increased transcriptional activity is associated with adiposity in two distinct Mexican-American cohorts, results suggest that adipocyte CRTC3 may play a role in the development of obesity in humans PMID: 21164481
10. Mucoepidermoid carcinomas possessing CRTC3-MAML2 fusion may be associated with favorable clinicopathological features and patients may be younger than those with CRTC1-MAML2 fusion or those with no detectable gene fusion. PMID: 19749740
11. transducer of regulated cyclic AMP-response element-binding protein 3 (TORC3), a co-activator of CREB, is involved in Tax-induced transcriptional activation from the HTLV-I LTR PMID: 15466468
12. These results strongly suggest that TORCs play a key role in linking these external signals to the transcriptional program of adaptive mitochondrial biogenesis by activating PGC-1alpha gene transcription. PMID: 16980408
13. BCL3 functions as a repressor of HTLV-1 LTR-mediated transcription through interactions with TORC3 PMID: 17644518
14. study reports for the first time a CRTC3-MAML2 fusion gene in a mucoepidermoid carcinoma, as determined by RT-PCR and sequencing. PMID: 18050304

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HGNC: 26148

OMIM: 608986

KEGG: hsa:64784

STRING: 9606.ENSP00000268184

UniGene: Hs.567572