DLG2 Recombinant Monoclonal Antibody

1. DLG2 influenced the risk of Parkinson disease in Taiwan. PMID: 29290481
2. Two novel promoters and coding first exons in the DLG2 gene were identified. These novel isoforms are expressed in the fetal brain. Deletions of these new elements were found associated with neurodevelopmental disorders. The work brings evidence for the lack of cross-annotation in human versus mouse reference genomes and nucleotide versus protein databases. PMID: 28724449
3. DLG2 - novel candidate genes validated in a large case-control sample of schizophrenia. PMID: 26460480
4. The PDZ1 domain of PSD-93 might accept peptides with larger residues at the C-terminus than that of PSD-95, for example the GluD2 C-terminal Ile versus the Val found at the C-terminus of NMDA receptors. PMID: 23519667
5. This study showed that DLG2 is related the complex learning. PMID: 23201973
6. Comparison of the structures of the binding cleft of PSD-93 PDZ1 with the previously reported structures of PSD-93 PDZ2 and PDZ3 as well as of the closely related human PSD-95 PDZ1 shows that they are very similar in terms of amino-acid composition PMID: 20054121
7. Variation at the DLG2 locus contributes to maintenance of glucose homeostasis through regulation of insulin sensitivity and beta-cell function. PMID: 19931931
8. Coexpression of Kir2.1 and PSD-93delta had no discernible effect upon channel kinetics but resulted in cell surface Kir2.1 clustering and suppression of channel internalization. PMID: 15304517
9. identifies new isoform of DLG2 gene, which contains 3'-end exons of the known DLG2 gene along with the hypothetical gene FLJ37266; new isoform is specifically upregulated in renal oncocytoma PMID: 16640776
10. postsynaptic density-93 and N-methyl-D-aspartate receptors subunits 2B mRNA are upregulated in temporal lobe tissue of epilepsy PMID: 17506987

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HGNC: 2901

OMIM: 603583

KEGG: hsa:1740

STRING: 9606.ENSP00000365272

UniGene: Hs.367656