DLG2 Antibody

Datasheet

Code	CSB-PA621882LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Rat heart tissue All lanes: DLG2 antibody at 2.8μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 98, 110, 84, 101, 39 kDa Observed band size: 98 kDa Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA621882LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA621882LA01HU at dilution of 1:100 Immunofluorescence staining of HepG2 cells with CSB-PA621882LA01HU at 1:233, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DLG2 Polyclonal antibody

Uniprot No.

Q15700

Target Names

DLG2

Alternative Names

Channel associated protein of synapse 110 antibody; Channel associated protein of synapses 110kD antibody; Channel-associated protein of synapse-110 antibody; Chapsyn 110 antibody; Chapsyn-110 antibody; Chapsyn110 antibody; Discs; large homolog 2 (Drosophila) antibody; Disks large homolog 2 antibody; DKFZp781D1854 antibody; DKFZp781E0954 antibody; Dlg 2 antibody; dlg2 antibody; DLG2_HUMAN antibody; Dlgh 2 antibody; Dlgh2 antibody; FLJ37266 antibody; Gm1197 antibody; MGC131811 antibody; Postsynaptic density protein PSD 93 antibody; Postsynaptic density protein PSD-93 antibody; Postsynaptic density protein PSD93 antibody; PSD 93 antibody; PSD93 antibody

Raised in

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant Human Disks large homolog 2 protein (310-420AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The DLG2 Antibody (Product code: CSB-PA621882LA01HU) is Non-conjugated. For DLG2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA621882LB01HU	DLG2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA621882LC01HU	DLG2 Antibody, FITC conjugated
Biotin	CSB-PA621882LD01HU	DLG2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:200-1:500

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses.

Gene References into Functions

DLG2 influenced the risk of Parkinson disease in Taiwan. PMID: 29290481
Two novel promoters and coding first exons in the DLG2 gene were identified. These novel isoforms are expressed in the fetal brain. Deletions of these new elements were found associated with neurodevelopmental disorders. The work brings evidence for the lack of cross-annotation in human versus mouse reference genomes and nucleotide versus protein databases. PMID: 28724449
DLG2 - novel candidate genes validated in a large case-control sample of schizophrenia. PMID: 26460480
The PDZ1 domain of PSD-93 might accept peptides with larger residues at the C-terminus than that of PSD-95, for example the GluD2 C-terminal Ile versus the Val found at the C-terminus of NMDA receptors. PMID: 23519667
This study showed that DLG2 is related the complex learning. PMID: 23201973
Comparison of the structures of the binding cleft of PSD-93 PDZ1 with the previously reported structures of PSD-93 PDZ2 and PDZ3 as well as of the closely related human PSD-95 PDZ1 shows that they are very similar in terms of amino-acid composition PMID: 20054121
Variation at the DLG2 locus contributes to maintenance of glucose homeostasis through regulation of insulin sensitivity and beta-cell function. PMID: 19931931
Coexpression of Kir2.1 and PSD-93delta had no discernible effect upon channel kinetics but resulted in cell surface Kir2.1 clustering and suppression of channel internalization. PMID: 15304517
identifies new isoform of DLG2 gene, which contains 3'-end exons of the known DLG2 gene along with the hypothetical gene FLJ37266; new isoform is specifically upregulated in renal oncocytoma PMID: 16640776
postsynaptic density-93 and N-methyl-D-aspartate receptors subunits 2B mRNA are upregulated in temporal lobe tissue of epilepsy PMID: 17506987

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Subcellular Location

Cell membrane; Lipid-anchor. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Membrane. Cell projection, axon. Perikaryon.

Protein Families

MAGUK family

Database Links

HGNC: 2901

OMIM: 603583

KEGG: hsa:1740

STRING: 9606.ENSP00000365272

UniGene: Hs.367656

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Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Hippo signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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