DNMT1 Recombinant Monoclonal Antibody

1. DNMT1-isoform3, instead of isoform1, is responsible for mtDNA methylation, influencing its biology. PMID: 28484249
2. DNMT1 was revealed as a direct target of miR148a by dual luciferase reporter assay, and restoration of miR148a could reactivate TSGs, such as p16, preproenkephalin and Ras association domain family member 1 by targeting DNMT1 in the AsPC1 pancreatic cancer cell line PMID: 30226601
3. Hyperthyroid patients with newly diagnosed Graves disease had global hypomethylation and lower DNMT1 expression in T and B lymphocytes. PMID: 29336230
4. Repression of Dok7 expression via DNMT1 mediated DNA methylation promotes glioma cell proliferation. PMID: 29990858
5. MiR-139-5p suppresses the migration and invasion of osteosarcoma cell lines. MiR-139-5p decreases DNMT1 expressions in osteosarcoma lines. PMID: 29673587
6. High DNMT1 expression is associated with bladder cancer. PMID: 30015946
7. These findings indicated that rs2228611 might contribute to male hypertension via BMI-dependent mechanisms in obesity male and BMI-independent mechanisms in normal weight male. PMID: 29400588
8. UV-induced expression of DNMT1 may be responsible for mediating DNA hypermethylation in TIMP2, and thus, silencing its expression, in UV-exposed human skin. PMID: 29685765
9. Findings suggested that tumor overexpression of DNMT1 and DNMT3A is associated with tumor aggressive behavior and high-methylation status in pituitary adenomas. Data support a possible role of DNMT1 and DNMT3A in TSG promoter methylation leading to pituitary adenoma invasion. PMID: 30002361
10. Knockdown of DNMT1 could block the role of miR-148a in promoting myocardial differentiation of human bone mesenchymal stromal cells. PMID: 28656724
11. Data show that long noncoding RNA LUCAT1 activated DNA methyltransferase 1 (DNMT1), a major DNA methylation protein, to repress the expression of tumor-suppressor genes, leading to the development and progression of esophageal squamous cell carcinoma (ESCC). PMID: 29247823
12. Genetic variation in DNMT1 gene is not associated with gastric cancer. PMID: 29956566
13. Study investigated the counteraction of oxidative stress by vitamin E in the colorectal cancer cell line Caco-2 under normal and high glucose cell culture condition. Gene expression and promoter methylation of the DNA repair gene MutL homolog 1 (MLH1) and the DNA methyltransferase 1 (DNMT1) were investigated. Induction of MLH1 and DNMT1 gene expression was noticed, accompanied by an increase in global methylation. PMID: 29854080
14. The finding that zebularine upregulates CYP gene expression through DNMT1 and PKR modulation sheds light on the mechanisms controlling hepatocyte function and thus may aid in the development of new in-vitro systems using high-functioning hepatocytes PMID: 28112215
15. Results show that upon DNMT1 depletion, overall pattern of sites show significant differential methylation. PMID: 29598829
16. DNMT1 contributes to promoter hypermethylation and epigenetic NHERF1 silencing in colon cancer. PMID: 29901158
17. the expression of WIF-1 was low in GBC cells due to aberrant hypermethylation of its promoter region. Additionally, an alternative pathogenesis of GBC was indicated in which c-Jun causes hypermethylation of the WIF-1 promoter region, and represses the expression of WIF-1 through transcriptional regulation and interaction with DNMT1 as an early event in the tumorigenesis of GBC. PMID: 29693707
18. SAC decreased the levels of 5-methylcytosine, DNMT activity, messenger RNA (mRNA) and protein levels of DNMT1. Additionally, SAC treatment resulted in re-expression of the mRNA and proteins of silenced tumor suppressor gene CDKN1A accompany with reduced cell division control 2 expression. PMID: 29759079
19. This work revealed the critical function of GOLM1/miR-200a/DNMT1 signaling pathway on regulating lung adenocarcinoma cell proliferation PMID: 29710483
20. DNMT1 is associated with cell cycle and DNA replication gene sets in diffuse large B-cell lymphoma PMID: 29137822
21. both messenger RNA and protein levels of KLF2 in HUVEC co-treated with LPS and DNA methyltransferase (DNMT) 1 small interfering RNA were dramatically higher than that treated with LPS only. PMID: 28578476
22. By perturbing BCL11A-DNMT1 interaction, miR-137 impairs cancer stemness and suppresses tumor development in Triple negative breast cancer. PMID: 29975921
23. DNMT3B rs1569686 gene polymorphism in women might be a genetic marker for the susceptibility to recurrent spontaneous abortion PMID: 28940947
24. we demonstrated that the downregulation of CLDN6 is regulated through promoter methylation by DNMT1, which depends on the SMAD2 pathway, and that CLDN6 is a key regulator in the SMAD2/DNMT1/CLDN6 pathway to inhibit EMT, migration and invasion of breast cancer cells PMID: 28867761
25. GNAO1 transcription was inhibited by promoter hypermethylation, contributing to its low expression. It was further revealed that the silencing effect was regulated by methyltransferase 1 (DNMT1), and was further enhanced by transforming growth factor beta (TGF-beta). PMID: 29709639
26. These results demonstrate that targeting NFkappaB/PDL1/STAT3/DNMT1 axis is a new therapeutic strategy for preventing or overcoming the acquired resistance to sorafenib in hepatocellular carcinoma (HCC)patients PMID: 28627705
27. PPI decreased expression of DNMT1. Silenced HOTAIR reduced DNMT1 protein expression. Exogenously expressed HOTAIR resisted PPI-inhibited DNMT1 protein expression. Excessive EZH2 antagonized PPI-suppressed DNMT1 protein expression or vice versa. The interactions among HOTAIR, DNMT1 and EZH2, and reciprocal regulation of DNMT1 and EZH2 contribute to the overall responses of PPI. PMID: 29221985
28. Epigenetic enhancement of the post-replicative DNA mismatch repair of mammalian genomes by a Hemi-(m)CpG-Np95-Dnmt1 axis has been demonstrated for humans and mice. PMID: 27886214
29. DNMT1 is predictive of diffuse large B-cell lymphomas (DLBCLs) patients' survival, and suggest that DNMT1 could be a DLBCL therapeutic target due to its significant association with Ki-67. PMID: 29074044
30. This is the first demonstration that dysregulated KLF4 expression associates with poor differentiation of pancreatic cancer. Epigenetic activation of miR-152/DNMT1/KLF4 signaling pathway by dietary DIM causes differentiation and significant growth inhibition of pancreatic cancer cells, highlighting its translational implications for pancreatic and other cancers. PMID: 28659310
31. Investigations demonstrate that KLF5 genomic loci are hypermethylated at proximal exon 4 and suppression of DNA methyltransferase 1 (DNMT1) expression by ShRNAs or a methylation inhibitor 5-Aza-CdR can recover KLF5 expression. PMID: 28749461
32. (i) ectopic expression of miR-148a induces programmed cell death and represses cell proliferation by targeting DNMT1; (ii) miR-148a gene is regulated by DNA methylation and DNMT1 in prostate cancer. We conclude that miR-148a is silenced by DNA methylation and ectopic expression of miR-148a suppresses DNMT1 expression and induced apoptotic genes expression in hormone-refractory prostate cancer cells. PMID: 29596883
33. Results show that DNMT1 function is regulated by LSD1 which mediates its recruitment at the transcriptional start site of its target genes to modulates there epigenetic status by altering H3K4me2 and H3K9Ac and DNA methylation. PMID: 28811844
34. elevated DNMT1 was correlated with decreased PPAR-gamma, and increased proinflammatory cytokine production in the peripheral blood monocytes isolated from the patients with atherosclerosis, compared to those of healthy donors. PMID: 27530451
35. Results indicated that miR-152-3p can inhibit glioma cell proliferation and invasion activities by decreasing DNMT1. PMID: 28764788
36. PRIMA-1 could cause the demethylation of TP73, through DNMT1 depletion, to subsequently enhance the unfolded protein response PMID: 27533450
37. Results show that DNMT1 is highly expressed in lung tumors compared to normal tissues, and that DBCCR1 attenuates its expression suggesting a reciprocal regulation between genetic silencing of cancer suppressor genes and activating DNA methylation. PMID: 28427182
38. A decreased expression of anti-DNMT1 miRNAs might account for azacitidine resistance in higher-risk myelodysplastic syndrome and acute myeloid leukemia , and measuring miRNA expression before and during treatment might help predict primary or secondary azacitidine resistance PMID: 27881579
39. these findings revealed that miR-217 promotes fibroblasts senescence by suppressing DNMT1-mediated methylation of p16 and pRb by targeting the DNMT1 3'-UTR. PMID: 28380423
40. Ultraviolet B rays suppressed SIRT1 expression by activating AhR, and subsequently inhibited DNMT1 activity in CD4+ T cells from systemic lupus erythematosus patients. PMID: 28336124
41. DNMT1 expression is increased in low-grade gliomas and is associated with improved survival. Its expression is regulated by phosphorylated c-Jun and correlates with high DNA methylation. PMID: 28036297
42. in patents with chronic hepatitis B, data showed a DNMT1 overexpression significantly correlated to nucleo(t)side analogs (NA) therapy duration and higher regional mitochondrial DNA hypermethylation; this might suggest an epigenetic alteration that could be involved in one of the possible mechanisms of mitochondrial gene regulation during NAs therapy PMID: 27922198
43. The meta-analysis also suggested that DNMT1 rs16999593 (T/C) may be associated with gastric cancer, while rs2228611 (G/A) may be associated with breast cancer. In future research, large-scale and well-designed studies are required to verify these findings. PMID: 28473984
44. FQI1 mediates alteration of the tumor epigenome by DNMT1-LSF complex disruption, leading to aberrant DNA methylation and gene expression. PMID: 27845898
45. DNMT1-mediated transcriptional upregulation of IGF2 is a novel mechanism of resistance to HDIs, highlighting the role of epigenetic deregulation of IGF2 in HDI resistance and the potential value of the H19/IGF2 ICR hypermethylation and DNMT1 expression as predictive biomarkers in HDI-based anticancer therapies. PMID: 27582487
46. these results demonstrate crosstalk between the lysine demethylase KDM1A and the DNMT1, which could be involved in carcinogenesis independently of its role in DNA methylation PMID: 27449289
47. High DNMT1 expression is associated with drug resistance in breast cancer. PMID: 26980709
48. DNMT1 causes NR4A1 DNA hypermethylation and blocks insulin signaling in an Chinese patients with type 2 diabetes PMID: 27322146
49. MUC1-C activates the NF-kappaB p65 pathway, promotes occupancy of the MUC1-C/NF-kappaB complex on the DNMT1 promoter and drives DNMT1 transcription PMID: 27259275
50. increased expression of both DNA methytransferase I (DNMT1) and Survivin was observed and significantly correlated with the reduced miR-203 in NSCLC PMID: 27177222

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HGNC: 2976

OMIM: 126375

KEGG: hsa:1786

STRING: 9606.ENSP00000352516

UniGene: Hs.202672