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GBA encodes the glucocerebrosidase (GCase), a lysosomal glycoside hydrolase that catalyzes the hydrolysis of the glycolipid glucosylceramide (GlcCer) to glucose and ceramide. It is involved in the metabolism of sphingolipids. GBA deficiency results in the buildup of GlcCer and disruption of lipid balance. Gaucher's disease has been linked to human GBA gene mutations, which are numerically the most important risk factor for developing Parkinson's disease (PD), accounting for at least 5% of all PD cases. Furthermore, sporadic PD brains show a decrease in GBA activity.The recombinant GBA antibody was generated in vitro through inserting cloned GBA genes into expression vectors. The expression vector was then inserted into a mammalian cell to express this GBA antibody. It has been validated in ELISA, WB. Every step in the production was controlled strictly. You have no worries about the quality.
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