HSPB1 Antibody

Code CSB-RA010833A0HU
Size US$350
  • Western Blot
    Positive WB detected in: Hela whole cell lysate, PC3 whole cell lysate, 293T whole cell lysate, LO2 whole cell lysate, HT-29 whole cell lysate, K562 whole cell lysate
    All lanes: Hsp27 antibody at 0.62μg/ml
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 23 KDa
    Observed band size: 27 KDa

  • IHC image of CSB-RA010833A0HU diluted at 1:61.9 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-RA010833A0HU diluted at 1:61.9 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of MCF-7 cells with CSB-RA010833A0HU at 1:20, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).

  • Immunoprecipitating Hsp27 in Hela whole cell lysate
    Lane 1: Rabbit control IgG instead of CSB-RA010833A0HU in Hela whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
    Lane 2: CSB-RA010833A0HU (3μg) + Hela whole cell lysate (500μg)
    Lane 3: Hela whole cell lysate (20μg)

  • Overlay histogram showing Hela cells stained with CSB-RA010833A0HU (red line) at 1:50. The cells were fixed with 70% Ethylalcohol (18h) and then permeabilized with 0.3% Triton X-100 for 2 min. The cells were then incubated in 1x PBS /10% normal goat serum to block non-specific protein-protein interactions followed by primary antibody for 1 h at 4°C. The secondary antibody used was FITC goat anti-rabbit IgG (H+L) at 1/200 dilution for 1 h at 4°C. Control antibody (green line) was used under the same conditions. Acquisition of >10,000 events was performed.

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Product Details

Uniprot No. P04792
Target Names HSPB1
Alternative Names Heat shock 27kDa protein antibody; 28 kDa heat shock protein antibody; CMT2F antibody; DKFZp586P1322 antibody; epididymis secretory protein Li 102 antibody; Estrogen regulated 24 kDa protein antibody; Estrogen-regulated 24 kDa protein antibody; Heat shock 25kDa protein 1 antibody; Heat shock 27 kDa protein antibody; Heat shock 27kD protein 1 antibody; Heat shock 27kDa protein 1 antibody; Heat shock 28kDa protein 1 antibody; Heat Shock Protein 27 antibody; Heat shock protein beta 1 antibody; Heat shock protein beta-1 antibody; heat shock protein family B (small) member 1 antibody; HEL-S-102 antibody; HMN2B antibody; HS.76067 antibody; Hsp 25 antibody; HSP 27 antibody; Hsp 28 antibody; Hsp B1 antibody; Hsp25 antibody; HSP27 antibody; Hsp28 antibody; HspB1 antibody; HSPB1_HUMAN antibody; SRP27 antibody; Stress responsive protein 27 antibody; Stress-responsive protein 27 antibody
Species Reactivity Human
Immunogen A synthesized peptide derived from human HSPB1
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Monoclonal
Isotype Rabbit IgG
Purification Method Affinity-chromatography
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form Liquid
Tested Applications ELISA, WB, IHC, IF, FC, IP
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:50-1:200
IF 1:20-1:200
IP 1:200-1:1000
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Flow Cytometry (FC) Protocol
Immunoprecipitation (IP) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state
Gene References into Functions
  1. Data suggest that both the small heat shock protein HspB1/Hsp27 and the constitutive chaperone Hsc70/HspA8 interact with tau to prevent tau-fibril/amyloid formation. HspB1 delays tau-fibril formation by weakly interacting with early species in aggregation process. (HspB1 = heat shock protein family B small member 1; Hsc70 = heat shock protein family A Hsp70) PMID: 29298892
  2. HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis. PMID: 29650953
  3. Results show that HSP27 expression is significantly increased in metastatic prostate cancer and represents a strong marker predicting survival, along with ALDH6A1 and prohibitin. PMID: 30396985
  4. High HSP27 expression is associated with breast cancer. PMID: 30106436
  5. our data suggest that overexpression of peroxiredoxin-2, annexin A2, and heat shock protein beta-1 was correlated with tumor invasion, metastasis, and poor prognosis, and therefore, these proteins may serve as potential diagnostic and therapeutic biomarkers. PMID: 29332450
  6. ETAS down-regulated HSP27 and pHSP27 (serine 78) in KLM1-R cells, but, HSP70 and GRP78 levels were not altered. This study suggests the potential therapeutic benefit of ETAS in enhancing anticancer effects by its combination with gemcitabine for patients with pancreatic cancer PMID: 29936456
  7. Silencing of HSP27 increases curcumin resistance by reducing apoptosis and reactive oxidative stress production in colon cancer. PMID: 30056019
  8. The expression of type I and III collagen in the TGF-beta1induced transition of A549 cells to myofibroblasts was significantly downregulated by transfection of A549 cells with HSP27 plasmid Dinterfering sequence and optimal ratio of Lipofectamine(R) 2000 and HSP27 plasmid. PMID: 29568951
  9. It was suggested that the HSP27 expression in EUS-FNA samples was useful for predicting GEM sensitivity. PMID: 29695571
  10. High hsp27 expression is associated with leukemia. PMID: 29328466
  11. p-Hsp27 is a novel biomarker of glioma and might have important clinical value for further classification of patients with wild-type IDH1 and normal ATRX expression and for evaluating prognosis. PMID: 29550762
  12. Dimer-monomer equilibrium of human HSP27 is influenced by the in-cell macromolecular crowding environment and is controlled by fatty acids and heat. PMID: 29635040
  13. HSP27 expression promotes vascular smooth muscle cell viability, suppresses cell apoptosis, and confers protection against oxidative stress in Thoracic aortic dissection. PMID: 29209372
  14. Hsp27 and P38MAPK could be used as prognostic factors in Esophageal squamous cell carcinoma. PMID: 29099815
  15. Addition of apatorsen to chemotherapy does not improve outcomes in unselected patients with metastatic pancreatic cancer in the first-line setting, although a trend toward prolonged PFS and OS in patients with high baseline serum Hsp27 suggests this therapy may warrant further evaluation in this subgroup PMID: 28935773
  16. High HSP27 expression is associated with non-small cell lung cancer metastasis. PMID: 28656293
  17. Knockdown of HSP27 blocked TGF-beta-induced cisplatin resistance. PMID: 28848138
  18. The expression of HSP27 was approximately 2-fold higher in apical periodontitis. Next, an increased expression of HSP27 was detected in epithelial cells PMID: 28673495
  19. Findings indicate the heat-shock protein 27 (Hsp27) pathway as a therapeutic target for the management of conditions featuring dysregulated interleukin 1 beta (IL-1beta) production. PMID: 27976724
  20. Increased protein level of HSP27 through SUMO2/3-mediated SUMOylation plays crucial roles in the progression of primary hepatocellular carcinoma. PMID: 28665748
  21. When the correlations of the markers with the response to neoadjuvant chemotherapy were examined, only high pre-chemotherapy levels of cytoplasmic HSPB1/p correlated with a poor clinical and pathological response to neoadjuvant cisplatin chemotherapy (p = 0.056) suggesting that this marker could be useful opening its study in a larger number of cases. PMID: 28608263
  22. Exposure to cetuximab and various concentration of AG490, an inhibitor of JAK2, STAT3 and HSP27 protein levels, except in the KRAS G12V mutant line, SW620...cetuximab may promote SN38 sensitivity via suppression of HSP27, through blocking the JAK/STAT signaling pathway, and shows synergistic effects when combined with SN38 in wild-type RAS CRC cells. PMID: 28656305
  23. we concluded that HSP27-silenced placenta-derived multipotent cells differentiated into neurons possessing the characteristics of functional glutamatergic neurons. PMID: 27444754
  24. Data show that Hsp27increases degradation rate of ubiquitinated MST1 and therefore interrupts the Hippo pathway kinase cascade. Consequently YAP and TAZ are less phosphorylated, free to translocate into the nucleus promoting a malignant phenotype. These findings underscore the central importance of Hsp27 in regulating multiple signaling pathways that promote tumor aggressiveness. PMID: 27555231
  25. upregulation of Hsp27 is a common phenomenon shared between pregnancies in patients with preterm prelabor rupture of membranes and spontaneous preterm labor with intact membranes PMID: 28497897
  26. HSP27 is an independent predictor of prognosis in chronic HF PMID: 28844461
  27. Hsp27 may up-regulate the expression of ABCA1 and promotes cholesterol efflux through activation of the PI3K/PKCzeta/Sp1 signal pathway in THP-1 macrophage-derived foam cells PMID: 28610841
  28. This study reports solution-state nuclear magnetic resonance spectroscopy investigations of the conformation and dynamics of the disordered and flexible C-terminal region of human HSP27. These data indicate a potential role for cis-trans proline isomerization in regulating the oligomerization. PMID: 28547731
  29. Overexpression of both HSPB5 and Hsp27 significantly reduced the intracellular aggregation of alpha-synuclein. PMID: 28337642
  30. HspB1 structural organization displays dynamic and complex rearrangements in response to changes in the cellular environment or when the cell physiology is modified. [review] PMID: 28144778
  31. Glutathione-S-transferase - HspB1 fusion protein prevents more aggregation of malate dehydrogenase compared to glutathione-S-transferase -HspB5 fusion protein and wild type HspB1. PMID: 28130664
  32. The data suggest that oncogene-addicted cells require the small heat-shock protein of 27 kDa (HSP27) for survival and that HSP27 might interfere with the effectiveness of targeted agents. PMID: 28182330
  33. Data indocate six cytostatic drugs which inhibit heat shock 27 kDa protein (HSP27) and tackle drug resistance by computational drug repositioning approach. PMID: 27626687
  34. Different from C-M-T phenotype in hereditary neuropathies caused by mutations in the HSPB1 gene. PMID: 27816334
  35. found knock down of HSPB1 further increased the proportion of apoptotic cells in hyperthermic treated melanoma cells when compared with either single agent alone, and both agents leaded to cell cycle arrest at G0/G1 or G2/M phases PMID: 27626679
  36. Data suggest that altered dimerization of HSP27 represents a good strategy for anticancer therapy in HSP27-overexpressing cancer cells. PMID: 27449291
  37. Apatorsen ( 2'-methoxyethyl-modified antisense oligonucleotide that inhibits Hsp27 expression)was tolerated at the highest dose evaluated (1000 mg). Single-agent activity was suggested by changes in tumor markers, circulating tumor cells , and stable measurable disease PMID: 27022067
  38. this results show the central role of Hsp27 in RACK1 pseudosubstrate or LPS-induced cell activation of primary leukocytes PMID: 27178349
  39. High p-Hsp27 expression is associated with cisplatin resistance in lung cancer. PMID: 26872057
  40. Low p-Hsp27 expression is associated with pancreatic cancer. PMID: 26895107
  41. The up-regulation of Hsp27 by E2 is mediated by ERalpha/Sp1. PMID: 27179757
  42. Study report a novel interaction between mutant HSPB1-P182L and the RNA binding protein PCBP1, leading to a reduction in its translational repression activity. Identifying PCBP1 mRNA targets revealed a marked prevalence for an RNA recognition motif, preferably seen in their 5' and 3'UTRs. Findings further support a role for mutant HSPB1 in neurodegenerative diseases. PMID: 28077174
  43. Hsp 70 and Hsp 27 were expressed in middle ear effusions PMID: 28964286
  44. High Hsp27 expression is associated with Thyroid Tumors. PMID: 26970173
  45. Bradykinin stimulates myofibroblast migration through protein kinase D-mediated activation of COX-2 and Hsp27. PMID: 28032559
  46. Data suggest that HSPB6 forms hetero-oligomers with HSPB1 under the following rules: (1) highly conserved motif RLFDQXFG is necessary for subunit exchange among oligomers, (2) a site about 20 residues downstream of this motif determines size of resultant hetero-oligomers, and (3) a region in the N-terminal domain that is unique to HSPB6 dictates preferential formation of heterodimers. (HSP = heat shock protein) PMID: 28487364
  47. TNF-alpha stimulates colonic myofibroblast migration through P38 MAPK-mediated activation of COX-2 and Hsp27. PMID: 27451881
  48. The potency of the sHsps to suppress aggregation of model substrates is correlated with their ability to form stable substrate complexes; especially HspB1 and HspB5, but also B3, bind tightly to a variety of proteins PMID: 27909051
  49. This work examines the molecular mechanism by which two canonical sHsps, alphaB-crystallin (alphaB-c) and Hsp27, interact with aggregation-prone alpha-syn to prevent its aggregation in vitro Both sHsps are very effective inhibitors of alpha-syn aggregation PMID: 27587396
  50. This study highlights a novel relation between serum pHSP27 and BMD in Indian women however, these findings need to be confirmed in larger studies PMID: 27241641
  51. High HSP27 expression is associated with chemoresistance in neoplasms. PMID: 27600495
  52. In this instance, the ATP5B/CALR/HSP90B1/HSPB1/HSPD1-signaling network was revealed as the predominant target which was associated with the majority of the observed protein-protein interactions. As a result, the identified targets may be useful in explaining the anticancer mechanisms of ursolic acid and as potential targets for colorectal cancer therapy. PMID: 28347227
  53. Soluble glycoprotein 130 and hsp27 are novel candidate biomarkers for diagnosing Chronic Heart Failure with preserved ejection fraction and thus warrant further investigation; neither dpp4 nor CTSS showed promise as biomarkers of Chronic Heart Failure. PMID: 27067668
  54. Addition of the Hsp27 inhibitor KRIBB3 (5-(5-ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)-isoxazol) to Jurkat cells resulted in glutathione redox imbalance (increased GSSG and increased glutathione reductase activity), a decrease in Hsp70 concentrations, and also increased cell apoptosis PMID: 28026811
  55. HSP27 expression is upregulated in lung fibroblasts during pulmonary fibrosis, and subsequently, HSP27 modulates lung fibroblast differentiation through the Smad3 and ERK pathways. PMID: 27909724
  56. TRAP-induced activation of Akt in addition to p38 MAP kinase positively regulates the release of phosphorylated-HSP27 from human platelets, which is closely related to the platelet hyper-aggregation in type 2 diabetes mellitus patients. PMID: 27187380
  57. phosphorylated Hsp27 stimulates autophagy and lipid droplet clearance and interacts with STAT3. PMID: 27185187
  58. The expression levels of HSP27 and HSP90 are elevated in acute pulmonary embolism reflecting endothelial dysfunction. PMID: 26761580
  59. High expression of HSP27 is associated with molecular apocrine breast cancer. PMID: 26711786
  60. HSP27 was found to be regulator of translation initiation and STAT3 level. Therefore, it suggests that HSP27 is a key protein during placental development and trophoblast cell differentiation. PMID: 27714564
  61. HSP27 played a protective role against homocysteine-induced endothelial apoptosis through modulation of reactive oxygen species production and the mitochondrial caspase-dependent apoptotic pathway. PMID: 27190988
  62. A meta-analysis found no association between rs2868370 genotypes and radiation-induced damage risk. However, rs2868371 showed a statistically increased risk of radiation-induced damage under CC vs. CG/GG model, especially in Caucasians and in esophageal damage. PMID: 26874728
  63. From the analysis of the hepatitis C virus (HCV)-positive group of 142 cases, those that were p-HSP27-positive had a larger tumor diameter and the portal vein invasion rate was high. PMID: 27354654
  64. The nuclear expression of phosphorylated and unphosphorylated forms of Hsp27 is a molecular marker of unfavorable squamous cell carcinoma of the larynx associated with lymphogenous metastasis and decreased total five-year survival. PMID: 27540972
  65. Ballooning degeneration is associated with down-regulation of liver HSP27 gene and protein expression, suggesting that ballooned hepatocytes fail to ensure a robust physiological response to metabolic-induced stress. PMID: 26935030
  66. Incubation with paclitaxel, and with carboplatin significantly reduced cell growth without a definitive increase of intracellular HSPB1 expression. PMID: 27354589
  67. A trend of increasing value for HSP90 was observed when comparing the Mayo Clinic SSIGN 1-2 versus SSIGN 3-5 risk groups (4.2 versus 4.6 mean values; p = 0.06); no difference has been observed for HSP27 (3.8 to 3.9; p = 0.08). PMID: 25188333
  68. We found that HSP27 exerted its chemoresistant role by inhibiting p21 transferring from the nucleus to the plasma through the activation of phosphorylated-Akt pathway. PMID: 26931434
  69. The action of HSP27 involves the antioxidative capacity and activation of mitochondrial autophagy (mitophagy). PMID: 27110324
  70. Overexpression of Hsp27 led to the forced invasion of hepatocellular carcinoma cells, whereas silencing Hsp27 attenuated invasion and metastasis of hepatocellular carcinoma cells in vitro and in vivo. PMID: 26941848
  71. Three of the differentially expressed heat-schock proteins, HSP90A, HSPB1, and HSPB2, are up-regulated in giant cell tumor of bone patients. PMID: 26782567
  72. Phosphorylated HSP27 could be a potentially useful biomarker that predicts the sensitivity of pancreatic cancer to gemcitabine-based chemotherapy. PMID: 26805817
  73. The present study investigated the effects of small hairpin (sh)RNA-mediated HSP27 knockdown on the anticancer effects of quercetin in U937 human leukemia cells. PMID: 26648539
  74. HSP27 overexpression is associated with primary liver tumors. PMID: 26169728
  75. Hsp27-Ubc9 pathway recognizes the conformation of mutant CFTR which leads to its SUMO-2 conjugation and degradation by the ubiquitin-proteasome system. PMID: 26627832
  76. Suggest that R-Ras regulates angiogenic activities of endothelial cells in part via inhibition of the p38MAPK-HSP27 axis of VEGF signaling. PMID: 27029009
  77. The authors now show that human cytomegalovirus more robustly upregulated Mcl-1 than normal myeloid growth factors and that Mcl-1 was the only myeloid survival factor to rapidly induce HSP27 prior to the 48-h cell fate checkpoint. PMID: 26739047
  78. role in myofibroblast differentiation and development of pulmonary fibrosis PMID: 26859835
  79. FXa inhibitor reduces the collagen-stimulated release of phosphorylated HSP27 from human platelets due to the inhibition of HSP27 phosphorylation via p44/p42 MAP kinase PMID: 26867010
  80. In clinical specimens of non-small cell lung cancer, HSPB1 expression was absent from tumor endothelial cells undergoing the endothelial-to-mesenchymal transition PMID: 26744531
  81. HSP27 expression level is associated with the degree of chronic inflammation in Benign Prostatic Hyperplasia (BPH) and may participate in the pathological process in inflammatory BPH PMID: 26434601
  82. Data show there is an inverse correlation between heat shock protein 27 (HSP27) expression and gemcitabine (GEM) sensitivity of pancreatic cancer SW1990 cells. PMID: 26348464
  83. ANX1 and HSP27 are two novel biomarkers for predicting invasive HCC phenotypes. PMID: 26431426
  84. HSPB1 was expressed in blood vessels but scarcely in the parenchyma in patient with multiple sclerosis PMID: 26694816
  85. The genetic polymorphisms in LIG4 rs1805388 and HSPB1 rs2868371 were not obviously correlated with the risk of radiation pneumonitis and radiation-induced lung injury of lung cancer. PMID: 25811031
  86. Unphosphorylated HSP27 associates with eIF4E in osteoblasts and suppresses the translation initiation process. PMID: 26151374
  87. present the clinical and electrophysiological data on a multigenerational family with the p.Arg136Leu HSP27 mutation. PMID: 25547330
  88. Quantitative proteomic analysis was performed to help elucidate a molecular distinction between glioblastoma and oligodendroglioma; analysis showed HSPB1 and NOVA1 to be discriminating factors. PMID: 26108672
  89. Release of phosphorylated HSP27 from platelets is accompanied by the acceleration of aggregation in diabetic patients. PMID: 26046355
  90. HSP27 is upregulated in low BMD condition in both premenopausal and postmenopausal women. PMID: 26063949
  91. Stromal expression of heat-shock protein 27 is associated with worse clinical outcome in patients with colorectal cancer lung metastases PMID: 25793600
  92. findings reveal an essential role for HSPB1 in iron metabolism with important effects on ferroptosis-mediated cancer therapy. PMID: 25728673
  93. siRNA experiments confirmed that a reduction in Hsp27 or Hsp40 rescued CFTR in the DeltaF508 mutant, but the rescue was not additive or synergistic with C4 + 18 treatment, indicating these correctors shared a common pathway for rescue PMID: 26336106
  94. The nuclear expression of phosphorylated and non-phosphorylated forms of the chaperone HspB1 is a marker of tumor cells associated with lymphatic metastasis of breast cancer. PMID: 25519015
  95. N-terminal mutations increase stability of large HspB1 homooligomers, prevent their phosphorylation-dependent dissociation, modulate their interaction with HspB6 and decrease their chaperoning capacity, preventing normal functioning of HspB1. PMID: 25965061
  96. Study shows that Hsp27 is expressed in nearly 80% of non-small cell lung cancer patients and that erlotinib or chemotherapy increases its expression levels leading to chemoresistance. PMID: 25740245
  97. analysis of signaling cooperation between p38-MAPK/MAPKAP-2/Hsp27 and intracellular calcium release in AA-induced HBEC apoptosis PMID: 24802256
  98. A pivotal role of HSP27 in regulating bladder smooth muscle contraction. PMID: 26256887
  99. the ratio of phosphorylated HSP27 to nonphosphorylated HSP27 rather than the cellular level of HSP27 itself acts biphasically as a determinant of cellular fate in gemcitabine-resistant pancreatic cancer cells. PMID: 25615626
  100. Heat shock protein 27 and its regulatory molecules express differentially in SLE patients with distinct autoantibody profiles PMID: 25655337

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Involvement in disease Charcot-Marie-Tooth disease 2F (CMT2F); Neuronopathy, distal hereditary motor, 2B (HMN2B)
Subcellular Location Cytoplasm, Nucleus, Cytoplasm, cytoskeleton, spindle
Protein Families Small heat shock protein (HSP20) family
Tissue Specificity Detected in all tissues tested: skeletal muscle, heart, aorta, large intestine, small intestine, stomach, esophagus, bladder, adrenal gland, thyroid, pancreas, testis, adipose tissue, kidney, liver, spleen, cerebral cortex, blood serum and cerebrospinal f
Database Links

HGNC: 5246

OMIM: 602195

KEGG: hsa:3315

STRING: 9606.ENSP00000248553

UniGene: Hs.520973

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