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| Code | CSB-RA010087A0HU |
| Size | US$210 |
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The DNA sequence coding for the histone H1.0 monoclonal antibody produced from the animals with human synthesized histone H1.0 peptide immunization was cloned into the expression vector, which was further transfected into a cell line for in vitro expression. The product is the recombinant histone H1.0 monoclonal antibody. It specifically targets the human histone H1.0. It belongs to the rabbit IgG. The affinity-chromatography purification method was used to purify this histone H1.0 antibody. This histone H1.0 can be used in ELISA.
Histone H1.0 is the most common variation at nucleoli-associated DNA domains (NADs), rDNA, and other repetitive sequences important in nucleolar structure. Histone H1.0 is a linker histone that plays a role in cell differentiation, stem cell maintenance, tumorigenesis, and extracellular vesicle (EV) formation, as well as affecting epigenetic and functional intra-tumor heterogeneity. H1.0 or its post-translational forms have also been discovered in EVs generated by cancer cells in culture, implying that these cells may avoid differentiation at least in part by discarding H1.0 via the EV route.
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