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LRRK2 belongs to the ROCO protein family and is a large multidomain protein. In cells, LRRK2 phosphorylates a set of Rab GTPases, which is accelerated by Parkinson's disease-related LRRK2 mutations. Evidence has shown that LRRK2 governs intracellular vesicle trafficking and organelle maintenance, including Golgi, endosomes, and lysosomes. LRRK2 gene mutations are a common genetic risk factor for both familial and sporadic Parkinson's disease (PD). LRRK2 kinase activity has been demonstrated to be altered by its pathogenic mutations, and aberrant increases in LRRK2 kinase activity are thought to contribute to PD pathogenesis.CUSABIO cloned LRRK2 antibody-coding genes into plasma vectors and then transfected these vector clones into mammalian cells using a lipid-based transfection reagent. Following transient expression, the recombinant antibodies against LRRK2 were harvested and characterized. The recombinant LRRK2 antibody was purified by Affinity-chromatography from the culture medium. It can be used to detect LRRK2 protein from Human in the ELISA, IHC.
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