LRRK2, a member of the leucine-rich repeat kinase family, is a multidomain protein with GTPase and kinase activities. Encoded by the corresponding gene, LRRK2 features various structural domains, including ankyrin repeats, leucine-rich repeats (LRR), a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, an MLK-like domain, and a WD40 domain. This protein participates in diverse cellular processes, such as autophagy, neurite outgrowth regulation, synaptogenesis, membrane trafficking, and mitochondrial function. Additionally, LRRK2 exhibits close relationships with the ERK1/2 and Wnt signaling pathways, both influencing nuclear functions. Through phosphorylation of tau, actin, and tubulin, LRRK2 regulates microtubule dynamics, and these signaling pathways collectively modulate various physiological functions within cells.
LRRK2, a member of the leucine-rich repeat kinase family, is a multidomain protein with GTPase and kinase activities. Encoded by the corresponding gene, LRRK2 features various structural domains, including ankyrin repeats, leucine-rich repeats (LRR), a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, an MLK-like domain, and a WD40 domain. This protein participates in diverse cellular processes, such as autophagy, neurite outgrowth regulation, synaptogenesis, membrane trafficking, and mitochondrial function. Additionally, LRRK2 exhibits close relationships with the ERK1/2 and Wnt signaling pathways, both influencing nuclear functions. Through phosphorylation of tau, actin, and tubulin, LRRK2 regulates microtubule dynamics, and these signaling pathways collectively modulate various physiological functions within cells.
Recombinant Human Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2), partial
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
The following LRRK2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
LRRK2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA444926 | LRRK2 Antibody |
Human | ELISA,IHC |
CSB-PA902150 | LRRK2 Antibody |
Human | ELISA,IHC |
CSB-PA722493LA01HU | LRRK2 Antibody |
Human | ELISA, IHC, IF |
CSB-PA722493LB01HU | LRRK2 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA722493LC01HU | LRRK2 Antibody, FITC conjugated |
Human | |
CSB-PA722493LD01HU | LRRK2 Antibody, Biotin conjugated |
Human | ELISA |
CSB-RA797150A0HU | LRRK2 Recombinant Monoclonal Antibody |
Human | ELISA, IHC |
LRRK2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP722493HU CSB-EP722493HU CSB-BP722493HU CSB-MP722493HU CSB-EP722493HU-B |
Recombinant Human Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP722493HU1 | Recombinant Human Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2), partial |
E.coli |