PSMB9 Recombinant Monoclonal Antibody

1. Defective PSMB9/beta1i expression is likely to be one of the risk factors for the development of human uterine neoplasm. PMID: 28482675
2. single nucleotide polymorphism in PSMB9 are associated with hand dermatitis PMID: 27258892
3. Chinese females carrying the rs17587-G/G genotype in PSMB9 may increase a higher risk for Parkinson's disease. PMID: 27098790
4. The TAP1-rs1135216 and PSMB9-rs17587 variants are significantly associated with vitiligo, and even one copy of these mutant alleles can influence the risk among Saudis. PMID: 25548428
5. study found prevalence of LMP2-AA genotype was higher in acute myeolid leukemia (AML) patients while it was significantly lower in multiple myeloma (MM) cases than in the control subjects; results suggestLMP2 polymorphisms could play a role in the development of AML and MM PMID: 24377540
6. Data indicate that the codon 60 Arg/His polymorphism does not significantly alter the expression and activity of beta1i among the cell lines tested and clinical samples from colon and pancreatic cancer. PMID: 24040045
7. functional variants in PSMB9 may contribute to melanoma susceptibility. PMID: 23360169
8. LMP2 has a role as a tumor-suppressor and may have a role in uterine leiomyosarcoma therapy PMID: 22355695
9. Genetic polymorphisms of rs17587 of PSMB9 appeared to be associated with rheumatoid arthritis in ethnic Han Chinese from Yunnan. PMID: 23568741
10. study reports expression of LMP2 in patients with renal oncocytomas (RO) and eosinophilic variant of chromophobe renal cell carcinomas (CHRCC-EO); all CHRCC-EO cases (7 of 7) strongly showed nuclear LMP2 staining, as opposed to only 2 of 56 ROs; suggest its use as an aid in differential diagnosis of these neoplasias PMID: 22705098
11. LMP2 expression in nasopharyngeal carcinoma is associated with poor prognosis. PMID: 22287277
12. The polymorphic site is unique in the Chinese population of Han nationality at the LMP2 codon 60 loci (Arg60Cys), but a lack of association with lung cancer exists. PMID: 22261389
13. LMP2 may negatively regulate LMS independently of its role in the proteasome. PMID: 22659265
14. This is the first study to demonstrate that LMP2 variants can affect radiographic severity in ankylosing spondylitis. PMID: 22034108
15. Data show that LMP2 60HH variant reduces the risk to develop MS amongst Italian HLA-A*02+ females. PMID: 20174631
16. downregulation of expression in PBMC of chronic hepatitis B patients PMID: 20300807
17. data show that the proteasomal ss1i subunit is dysregulated in peripheral white blood cells and in inflammatory infiltrates of minor salivary glands in patients with Sjogren's syndrome PMID: 19833746
18. a high-frequency TAP1/LMP2 promoter polymorphism in human tumors PMID: 11788900
19. caspase inhibition led to elevated levels of LMP2 and oxidized proteins; results suggest an age-related loss in capacity to carry out apoptosis might contribute to the observed accumulation of oxidized proteins during aging and in age-related diseases. PMID: 15284441
20. These data suggest that LMP2 contributes to IkappaBalpha degradation and p50 generation, and that inhibition of LMP2 suppresses expression and activities of MMP-2 and MMP-9 by blocking the transfer of active NF-kappaB heterodimers into the nucleus. PMID: 16222703
21. LMP2-associated proteasome is recruited to the entire sequence of ER target genes, implicating a role for the proteasome in both transcription initiation and elongation. PMID: 16957778
22. These data reveal a novel "feed-forward" mechanism induced by NF-kappaB which ensures that acutely synthesized IRF-1 operates in concert with NF-kappaB to amplify the immunoproteasome and antigen-processing functions of CD40. PMID: 18694960
23. Downregulation of LMP2 is associated with acute myeloid leukaemic blasts. PMID: 19148137
24. Obtained data suggest the LMP2 and PSMA6 gene polymorphism significance as the risk factors of essential hypertension in adolescents. PMID: 19526842

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HGNC: 9546

OMIM: 177045

KEGG: hsa:5698

STRING: 9606.ENSP00000363993

UniGene: Hs.654585