Code | CSB-RA010791A326phHU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
Phospho-HSF1 (S326) antibody CSB-RA010791A326phHU is a recombinant monoclonal antibody belonging to rabbit IgG. Its production procedures include: the acquisition of the phospho-HSF1 (S326) monoclonal antibody using the phosphopeptide corresponding to human EIF2S1 (phospho S326) immunizes animals; the determination of DNA sequence of the phospho-HSF1 (S326) monoclonal antibody; the clone of the DNA sequence into the plsamid and subsequent transfection into cell lines for expression. This phospho-HSF1 (S326) antibody underwent purification using affinity chromatography. It has been tested in multiple applications, including ELISA, WB, and IHC. It specifically targets the human HSF1 phosphorylated at Ser 326 residue.
HSF1 orchestrates a complex transcriptional mechanism that aids adaptability and survival in stressful situations. It keeps track of the structural integrity of the proteome. Stresses such as thermal shock, hypoxia, heavy metals, reactive oxygen species, and pH shifts stimulate the activation of HSF1. HSF1 is involved in the initiation of tumors as well as the promotion and maintenance of cancer cell proliferation. Phosphorylation of S326 by AKT1, mTOR, p38, and MEK1 is a key regulator of HSF1 transcriptional activity.
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