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The expression of phospho-MAPT (S202) recombinant monoclonal antibody typically involves the initial step of incorporating the MAPT antibody-encoding gene into expression vectors. These vectors are then introduced into host cells via polyethyleneimine-mediated transfection. Subsequent culturing of the host cells leads to the production and secretion of these antibodies. After purification through affinity chromatography, the antibodies' functionality is evaluated using ELISA and FC assays, demonstrating their specific binding to the human MAPT protein phosphorylated at S202.
MAPT, when phosphorylated at S202 and other sites, can modulate the stability and dynamics of microtubules in neurons. Phosphorylation of MAPT at S202, in particular, is associated with tau hyperphosphorylation and aggregation, contributing to neuronal damage and cognitive decline in Alzheimer's disease.
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