Code | CSB-RA901354A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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IHC | 1:50-1:200 |
The production of the phospho-MAPT (S404) recombinant monoclonal antibody generally begins with the incorporation of the MAPT antibody-encoding gene into expression vectors. These vectors are then delivered into host cells through polyethyleneimine-mediated transfection. The host cells, housing the expression vectors, are cultured to generate and release the antibodies. Subsequent purification using affinity chromatography is followed by assessments through ELISA and IHC assays, verifying their ability to specifically bind to the human MAPT protein phosphorylated at S404.
MAPT phosphorylated at S404 represents a specific post-translational modification of the MAPT protein. Phosphorylation of MAPT at S404 is involved in the regulation of microtubules and neuronal function and is associated with neurodegenerative diseases, particularly Alzheimer's disease.
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