STX3 Recombinant Monoclonal Antibody

1. Stx3S is differentially expressed in normal human tissues, during epithelial cell polarization, and in breast cancer versus normal breast tissue. Inhibition of endogenous Stx3S expression alters the expression of cancer-associated genes and promotes cell proliferation. PMID: 29475951
2. mechanism study shows that STX3 binds to PTEN and increases PTEN ubiquitination and degradation, thus leading to activation of the PI3K-Akt-mTOR signaling. Therefore, STX3 promotes the growth of breast cancer cells by regulating the PTEN-PI3K-Akt-mTOR signaling. PMID: 29408595
3. we report for the first time a missense mutation of a novel lens specific gene STX3 in a phenotype associating autosomal recessive congenital cataract and intellectual disability. PMID: 25358429
4. GLUT5 required an interaction cascade of Rab11, Myo5B, Slp4a, Munc18-2, and Vamp7 with Stx3. PMID: 26553929
5. Rab11a-knockdown cells displayed mislocalization of STX3 and the presentation of microvilli in the basolateral compartment PMID: 25673875
6. the secretion of IL-1alpha, IL-1beta, IL-12b, and CCL4 occurs during gelatinase degranulation, a process controlled by STX3. PMID: 25548252
7. The results showed that there was reduction in aggregation propensity of syntaxin-3 with point mutation at Val286. PMID: 25630102
8. hcmv-miR-US33-5p-mediated inhibition of HCMV DNA synthesis and of viral replication are specifically mediated by down-regulation of STX3 expression. PMID: 25583387
9. loss of STX3 function causes variant microvillus inclusion disease PMID: 24726755
10. syntaxin3 has a latent prosurvival function and is involved in maintenance of homeostasis in epidermal keratinocytes PMID: 24171760
11. In insulin secretion, SYN-3 plays a role in the mediation of newcomer SG exocytosis and SG-SG fusion that contributes to biphasic GSIS. PMID: 23132338
12. siRNA knockdown (KD) of syntaxins 3 and 4 in HeLa cells reduced cell surface expression of alpha5beta1 and alpha3beta1 integrins PMID: 21720706
13. STX-3 and SNAP-23 are crucial for the release of all chemokines in mature human mast cells PMID: 21981832
14. These results demonstrate a function for STX3 in human cytomegalovirus morphogenesis, and unravel a new role for this SNARE protein in late endosomes/lysosomes compartments. PMID: 21371234
15. syntaxin 3 interacts with CFTR in vivo. PMID: 20844248
16. Munc18b is functionally coupled to the assembly of exocytic SNARE complexes and increases exocytosis by interacting with the N-peptide and closed-conformation C-terminus of Stx3, thereby neutralizing the secretion-inhibitory effect of this SNARE. PMID: 20695848
17. Data show that the BCG phagosome is relatively depleted in LAMP-2, NPC1, flotillin-1, vATPase, and syntaxin 3. PMID: 19815536

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HGNC: 11438

OMIM: 600876

KEGG: hsa:6809

STRING: 9606.ENSP00000338562

UniGene: Hs.180711