SUN2 Recombinant Monoclonal Antibody

SUN2 is a nuclear envelope protein that plays a fundamental role in connecting the nucleoskeleton to the cytoskeleton through the LINC complex. This connection is essential for nuclear positioning, mechanotransduction, and chromosome movement during meiosis. Researchers investigating nuclear mechanics, cellular migration, or diseases linked to nuclear envelope dysfunction will find SUN2 a compelling target, as its disruption has been implicated in muscular dystrophies and progeria-related conditions.

This recombinant monoclonal antibody, derived from rabbit host and produced against a synthetic peptide from human SUN2, offers the consistency that demanding experimental workflows require. Because the antibody sequence is defined and production is cell-line based, you can expect reliable performance across experiments and over time, eliminating the lot-to-lot variability that can complicate longitudinal studies or multi-site collaborations.

Validation data demonstrates robust performance across multiple applications. Western blot analysis detects a band at the predicted 80 kDa molecular weight in THP-1 human monocytic cells, with cross-species reactivity confirmed in mouse lung and brain tissues as well as rat brain tissue. For spatial localization studies, immunohistochemistry has been optimized in paraffin-embedded human liver tissue using citrate buffer antigen retrieval, with recommended dilutions between 1:50 and 1:100. Flow cytometry validation in Jurkat cells shows clear separation from isotype control, enabling quantitative analysis of SUN2 expression at the single-cell level.

Whether you are exploring nuclear envelope biology, mechanosensing pathways, or laminopathy-related disease mechanisms, this antibody provides the application flexibility and reproducibility needed to advance your research with confidence.