SUN2 is a protein in humans that is encoded by SUN2 gene. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.
The following SUN2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
SUN2 Antibodies for Arabidopsis thaliana (Mouse-ear cress)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA274201XA01DOA | SUN2 Antibody |
Arabidopsis thaliana | ELISA, WB (ensure identification of antigen) |
SUN2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA883386LA01HU | SUN2 Antibody |
Human, Mouse, Rat | ELISA, WB, IHC |
CSB-PA883386LB01HU | SUN2 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA883386LC01HU | SUN2 Antibody, FITC conjugated |
Human | |
CSB-PA883386LD01HU | SUN2 Antibody, Biotin conjugated |
Human | ELISA |
SUN2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF883386HU | Recombinant Human SUN domain-containing protein 2 (SUN2) |
in vitro E.coli expression system |
CSB-YP883386HU1 CSB-EP883386HU1 CSB-BP883386HU1 CSB-MP883386HU1 CSB-EP883386HU1-B |
Recombinant Human SUN domain-containing protein 2 (SUN2), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SUN2 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF804816MO | Recombinant Mouse SUN domain-containing protein 2 (Sun2) |
in vitro E.coli expression system |
CSB-YP804816MO1 CSB-EP804816MO1 CSB-BP804816MO1 CSB-MP804816MO1 CSB-EP804816MO1-B |
Recombinant Mouse SUN domain-containing protein 2 (Sun2), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SUN2 Proteins for Dictyostelium discoideum (Slime mold)
Code | Product Name | Source |
---|---|---|
CSB-YP703778DKK CSB-EP703778DKK CSB-BP703778DKK CSB-MP703778DKK CSB-EP703778DKK-B |
Recombinant Dictyostelium discoideum SUN domain-containing protein 2 (sun2), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |