TBP Recombinant Monoclonal Antibody

1. these studies support the idea that increases in TBP expression contribute to enhanced VEGFA transcription early in colorectal cancer development to drive tumorigenesis. PMID: 28415573
2. The genetic animal models of SCA17 clearly indicate that the phenotypes are dependent on the expression levels of mutant TBP and the length of CAG/glutamine repeat. PMID: 27859490
3. we observed that carriers of either ATXN7 or TBP alleles with relatively large CAG repeat sizes in both alleles had a substantially increased risk of lifetime depression. PMID: 28585930
4. Data indicate the crystal structure of a Brf2-TBP-Bdp1 complex bound to a DNA promoter. PMID: 28743884
5. Study could not determine a definitive cutoff value for the pathologic CAG repeat number of SCA17. PMID: 26267067
6. TBP attenuates Msx1-mediated glycoprotein hormone alpha transcriptional repression. PMID: 26505791
7. this analysis of the 2.2-kb doubly spliced RNA (2.2DS-RNA) -mediated suppression of viral RNA expression showed that 2.2DS-RNA inhibited transcription via binding to the TATA-binding protein and stress granule proteins. PMID: 26339052
8. Our results provide first evidence that Taspase1 processing affects TFIIA regulation of TFIID and suggest that Taspase1 processing of TFIIA is required to establish INR-selective core promoter activity in the presence of NC2. PMID: 25996597
9. TBP (and GATA2 and Sp1) have key roles in inflammation and ischemia-like conditions through MAOA regulation. PMID: 25810277
10. Deactivation of TBP contributes to SCA17 pathogenesis. PMID: 25104854
11. HOXA2 acts as a suppressor or TBP-antagonist to inhibit MMP-9 expression; while methylation-mediated inactivation of HOXA2 in NPC derepresses MMP-9 production and increases invasion of NPC cells. PMID: 24243817
12. The data reveal synergistic effects of H3K4me3, H3K14ac and a TATA box sequence on TFIID binding in vitro. Stoichiometry analyses of affinity purified human TFIID identified the presence of a stable dimeric core. PMID: 24039962
13. The UL4 protein directly interacted with the host TBP and the carboxy-terminal domain of RNA polymerase II in infected cells. PMID: 24418534
14. Findings indicate that using TATA-binding protein (TBP) alone or in combination with hydroxymethylbilane synthase (HMBS) as endogenous controls could be a reliable method for normalizing qRT-PCR data in hepatoma cell lines treated with TNF-alpha. PMID: 23811755
15. Ethanol increases Pol III transcription through a response element which is composed of the overlapping Elk1 and AP-1 binding sites of the TBP promoter. The binding sites may play a role in ethanol-induced deregulation of Pol III genes in liver tumors. PMID: 23454483
16. conclude that the oncoprotein HBXIP as a co-activator of TF II D transactivates Lin28B promoter via directly binding to TBP to upregulate the expression of Lin28B in promotion of proliferation of breast cancer cells PMID: 23494474
17. This study showed that five families with SCA17 represents a significant portion of ataxia cases in the population of the Czech Republic. PMID: 22872568
18. This study created a first transgenic rat model for SCA17 that carries a full human cDNA fragment of the TBP gene with 64 CAA/CAG repeats (TBPQ64). PMID: 23699518
19. effects of promoter TATA-box polymorphisms associated with human diseases on interactions between the TATA boxes and TATA-binding protein PMID: 23424617
20. These studies suggest a model in which the distinct conformations of TFIID may serve as targets through which regulatory factors recruit TFIID to specific types of core promoters. PMID: 23332750
21. TATA binding protein (TBP) interactions with oligonucleotides PMID: 23062343
22. CONCLUSIONS: The current case highlights the diagnostic challenge of neurodegenerative disorders and the need for a thorough clinical and paraclinical examination of patients. PMID: 22889412
23. The autosomal dominantly inherited progressive neurodegenerative disorder is caused by an expanded CAA/CAG repeat in the TATA-box binding protein PMID: 17853080
24. In Korean population, the mutation frequencies of SCA2 and SCA17 were similar. whereas SCA17 was a more significant cause of parkinsonism. PMID: 21334959
25. Expression of the transgenic TBP in Purkinje cells is sufficient to produce cell degeneration and an ataxia phenotype, and constitutes a good model for analysis of neurodegeneration in spinocerebellar ataxia type 17. PMID: 21554323
26. This study demonstrated mutant TATA box-binding protein at the endogenous level affects neuronal function, with important implications for the pathogenesis and treatment of polyglutamine diseases. PMID: 21705419
27. The data suggest that ICP4 interacts with components of TFIID and Mediator in the context of viral infection. PMID: 21450820
28. TBP mutations may be a very rare cause of Parkinson's disease in mainland China PMID: 20864379
29. Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression. PMID: 21106530
30. Brain weight correlated with the 'raw' (i.e. non-normalized) data for two mRNAs, beta2-microglobulin and TATA-binding protein, measured in cerebellum and hippocampus, respectively PMID: 20831744
31. Regulation of TBP by miR-146a may contribute to Huntington disease pathogenesis. PMID: 20451497
32. The DNA bend angle (theta) depends on the TATA sequence, with theta for coreTBP and human TBP being greater than that for yeast TBP. PMID: 19199812
33. In lymphoblastoid cells, HSPA5, HSPA8 and HSPB1 expression levels in cells with expanded SCA17 were significantly lower than that of the control cells. PMID: 20004653
34. TATA-binding protein-associated factor sharply decrease the rate at which Pol II, TFIIB, and TFIIF assemble on promoter-bound TFIID-TFIIA. PMID: 20083121
35. constitutive association of TBP with mitotic chromosomes PMID: 11809839
36. TBP can bind the TATA box through a regulated two-step mechanism, involving a transition from unbent complex to bent complex PMID: 11893333
37. Developmental specificity of recruitment of TBP to the TATA box of the human gamma-globin gene PMID: 11960008
38. Human papillomavirus-16 E7 protein inhibits the DNA interaction of the TATA binding transcription factor. PMID: 11968006
39. Data show that TATA-binding protein labelling was relatively more abundant than huntingtin labelling in the brains of Huntington disease patients, and increased with the grade of the disease. PMID: 12531510
40. Data show that human TATA box binding protein (TBP) can use a shared surface to interact with two different transcription factor IIB (TFIIB) family members to initiate transcription by different RNA polymerases. PMID: 12535529
41. spatial positioning of the DNA-bound activation domain is important for efficient activation, possibly by maximizing its interactions with the transcriptional machinery including the TBP-TFIIA-TFIIB-promoter quaternary complex PMID: 12538582
42. TBP expression is elevated in human colon carcinomas relative to normal colon epithelium. Both Ras-dependent and Ras-independent mechanisms mediate increases in TBP expression in colon carcinoma cell lines. PMID: 12697807
43. Sequence-dependent solution structure and motions of TBP complexes were studied. PMID: 12767124
44. simultaneously binds and bends promoter DNA without a slow isomerization step or TFIIB requirement PMID: 12791683
45. Our data provides biochemical evidence that Mediator functions by facilitating activator-mediated recruitment of pol II and also promoter recognition by TBP, both of which can occur in the absence of TBP-associated factors in TFIID PMID: 12917344
46. p300 plays a role in formation of the TBP-TFIIA-containing basal transcription complex, TAC. PMID: 12941701
47. Results present the X-ray structures of human and yeast TATA box-binding protein /transcription factor IIA/DNA complexes at 2.1A and 1.9A resolution, respectively. PMID: 12972251
48. in addition to its role in regulating TBP binding to a TATA box, the TBP surface is unexpectedly involved in TBP association with all three TFIIB family members PMID: 14585974
49. abnormal expansions of an allele in SCA8 and SCA17 genes were detected in patients with both Parkinson's disease and spinocerebellar ataxia PMID: 14756671
50. Analysis of Spinocerebellar ataxia type 17 (SCA17) locus in a group of ataxic patients excluded on other known SCAs. PMID: 14763955

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HGNC: 11588

OMIM: 600075

KEGG: hsa:6908

STRING: 9606.ENSP00000230354

UniGene: Hs.590872