Code | CSB-RA567167A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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IF | 1:20-1:200 |
The TYR recombinant monoclonal antibody is generated using recombinant DNA technology and is well-suited for detecting human TYR protein in ELISA and IF applications. The gene that encodes the TYR monoclonal antibody is synthesized after sequencing the cDNA of the TYR antibody-producing hybridomas. These hybridomas are created by fusing B cells from an animal that has been immunized with a synthesized peptide derived from human TYR with myeloma cells. After the gene is synthesized, it is cloned into a vector and then transfected into cells for cultivation. The resulting TYR recombinant monoclonal antibody is subjected to purified affinity chromatography purification.
The TYR protein is an enzyme that is involved in the production of melanin, the pigment that gives color to the skin, hair, and eyes. In cells, TYR catalyzes the oxidation of tyrosine to dopaquinone, which is then further processed to produce melanin. Mutations in the TYR gene can cause various types of albinism, a genetic condition characterized by a lack of melanin in the skin, hair, and eyes. TYR is also involved in the tanning response of the skin to UV radiation, as well as in the development of melanoma, a type of skin cancer that arises from melanocytes.
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