YY1 Antibody

Code CSB-RA026297A0HU
Size US$350
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Product Details

Uniprot No. P25490
Target Names YY1
Alternative Names CF1 antibody; Delta antibody; Delta transcription factor antibody; INO80 complex subunit S antibody; INO80S antibody; NF E1 antibody; NF-E1 antibody; NFE1 antibody; OTTHUMP00000197459 antibody; Transcriptional repressor protein YY1 antibody; TYY1_HUMAN antibody; UCR motif DNA binding protein antibody; UCRBP antibody; Yin and yang 1 antibody; Yin and Yang 1 protein antibody; Yin Yang 1 antibody; Ying Yang 1 antibody; YY 1 antibody; YY 1 transcription factor antibody; YY-1 antibody; YY1 antibody; YY1 transcription factor antibody
Species Reactivity Human
Immunogen A synthesized peptide derived from human YY1
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Monoclonal
Isotype Rabbit IgG
Purification Method Affinity-chromatography
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression
Gene References into Functions
  1. Data show that MiR-147b targets the 3' untranslated region (3'UTR) of Yin Yang 1 (YY1). PMID: 30060075
  2. Results show that YY1 is phosphorylated by c-Abl kinase at tyrosine residue 254 and that this phosphorylation likely modulates its transcriptional activity. PMID: 29807053
  3. YY1-CDKN3-MDM2/P53-P21 axis is involved in pancreatic tumorigenesis PMID: 29168185
  4. The repression of TBX21 expression by high-affinity binding of YY1 to the -1993C allele may contribute to a decreased development of AIH-1 via suppression of type 1 immunity. PMID: 29358858
  5. expression of miR-192-5p was negatively correlated with that of YY1 in bladder cancer tissues PMID: 29536411
  6. YY1 promoted glioma cell proliferation and miR218 could inhibit glioma cell proliferation by targeting YY1. PMID: 29138857
  7. miR-30a acts in a feedback loop to modulate the pro-autophagic activities of YY1. PMID: 29052509
  8. Data suggest a role for YY1 transcription factor (YY1) in transcriptional activity on inactive X (Xi) in general through sequence-specific binding, and its involvement at superloop anchors. PMID: 27857184
  9. Results suggest that up-regulation of YY1 is closely associated with the progression of cervical squamous cell carcinoma, and YY1 may play an important role in the pathogenesis of cervical cancer by modulating the expression of E-cadherin and HPV16 E6. PMID: 29470526
  10. Results show that histone deacetylase 1 (HDAC1) expression was positively correlated with YY1 transcription factor (YY1) in hepatocellular carcinoma (HCC) cell lines and primary tumor tissues. PMID: 28489564
  11. Authors found that YY1 and STAT1 were upregulated in ox-LDL-stimulating macrophages followed by translocation in the nucleus and binding to the transcriptional promoter region of miR-29a, thus leading to the increase of miR-29a expression. PMID: 28593745
  12. results support a model in which YY1 acts as an architectural protein to connect developmentally regulated looping interactions; the location of YY1-mediated interactions may be demarcated in development by a preexisting topological framework created by constitutive CTCF-mediated interactions. PMID: 28536180
  13. High expression of nuclear YY1 was significantly associated with higher AJCC stage and small vessel invasion. PMID: 28412749
  14. This is the first report on the status of YY1 T372R in insulinoma cases of Indian origin. PMID: 28472826
  15. YY1 promotes proliferation and migration with suppression of apoptosis via directly inhibiting MYCT1 in laryngeal cancer cells, suggesting that YY1 is a useful target as a potential oncogene in laryngeal cancer development and progression. PMID: 28485541
  16. These data suggested that YY1 may be important for apoptosis induction via the regulation of Fas during sepsis. Therefore, Fas may be a potential therapeutic target to prevent MOD through regulation of YY1 expression. Furthermore, YY1 and Fas expression in PBMCs may be used to as prognostic markers. PMID: 28447715
  17. Study shows that the ubiquitously expressed transcription factor Yin Yang 1 (YY1) contributes to enhancer-promoter structural interactions in a manner analogous to DNA interactions mediated by CTCF. PMID: 29224777
  18. YY1 was over-expressed in RA which can bind to the promotor of IL-6 to introduce IL-6 expression, contributing to the inflammation of RA via stimulation of Th17 differentiation. PMID: 27829535
  19. YY1 promotes apoptosis via upregulating Bax transcription and subsequent activation of Bax by translocation from the cytosol to the mitochondrial membrane. PMID: 27074573
  20. High YY1 expression is associated with Lung Cancer Progression. PMID: 28972861
  21. Low YY1 expression is associated with pancreatic ductal adenocarcinoma. PMID: 28867247
  22. PRE-PIK3C2B interacts directly with YY1 in vitro and recruits PRC2 complex in vivo. The localization of PcG proteins including YY1 to PRE-PIK3C2B in HEK cells is decreased on knock-down of either YY1 or SUZ12. PMID: 23805300
  23. YY1 promotes mTORC2-mediated AKT activation PMID: 26762111
  24. these results define a clinical syndrome caused by haploinsufficiency of YY1 through dysregulation of key transcriptional regulators. PMID: 28575647
  25. Interactions of the chromatin remodeling protein INO80 with DNA, and the role of YY1 in this process have been described. PMID: 27428271
  26. ZFs of YY1 are able to interact with multiple RNA sequences, and that their specificity is not limited to putative endogenous RNA target Xist. The mode of interaction appears to be distinct from both the DNA binding of YY1 and the RNA binding of other classical ZF proteins. PMID: 27369384
  27. the existence of both INO80 and YY1 is required for recruiting the INO80/YY1 complex to BCCIP promoter region. Our findings strongly indicate that BCCIP is a potential target gene of the INO80/YY1 complex. PMID: 27535137
  28. miR-215 is downregulated in colon cancer and it suppresses colon cancer cell proliferation, migration and invasion by directly targeting YY1 PMID: 27663660
  29. High YY1 expression is Associated with Endometrial Cancer. PMID: 27259051
  30. Our results suggested that YY1 depletion repressed prostate cancer cell viability and proliferation and induced apoptosis at least in a miR-146a-assisted manner. PMID: 28101571
  31. Knockdown of miR-381 target gene, YY1, mimicked the phenotype induced by miR-381 overexpression. PMID: 26768613
  32. SET7/SET9-mediated YY1 methylation was shown to be involved in YY1-regulated gene transcription and cell proliferation. PMID: 26902152
  33. The results of our study indicate that YY1 belongs to the family of intrinsically disordered proteins, which exist natively in a partially unfolded conformation. PMID: 25963536
  34. Study shows that YY1 regulates inflammatory responses in vascular endothelium through its binding to ANRIL. PMID: 26618242
  35. YY1 regulates lung CCL4 transcription in pulmonary tuberculosis. PMID: 26786659
  36. Significance of the pathogenic mutation T372R in the Yin Yang 1 protein interaction with DNA--thermodynamic studies: the mutation does not affect the secondary structure of either zinc fingers or the N-terminal fragment of the protein. PMID: 26910132
  37. YY1 overexpression contributes to EZH2 recruitment for H3K27me3-mediated silencing of tumour-suppressive microRNAs, thereby activating NF-kappaB signalling in hepatocarcinogenesis. PMID: 26800240
  38. IL-18 induced YY1 expression, which repressed FXR and MRP2 expression in HepG2 cells. PMID: 26292095
  39. YY1 is overexpressed in differentiated thyroid cancer, and more frequently overexpressed in the papillary carcinoma subtype. PMID: 25698133
  40. Results identify a novel YY1 ~ miR-9 ~ RYBP axis involved in melanoma tumorigenesis and reinforce the idea that regulatory circuitries involving miRNAs and TFs are prevalent mechanisms. PMID: 26104682
  41. Rescue experiments indicated that the suppressive effect of miR-34a on invasion and migration was mediated by activating YY1 expression. PMID: 25954903
  42. Results demonstrate that YY1 is a critical effecter in IL-13-induced fibroblast differentiation: increasing YY1 enhances it whereas decreasing YY1 reduces it. PMID: 25775215
  43. These findings imply that the T allele significantly suppresses PSCA expression in vivo by recruiting YY1 to its promoter, which eventually predisposes gastric epithelial cells to GC development PMID: 25727947
  44. Data show that YY1 transcription factor (YY1) is tyrosine-phosphorylated by Src family kinases, leading to down-regulation of its activity. PMID: 26198631
  45. YY1 is a transcription repressor of FEN1 regulating FEN1 levels in response to DNA damaging agents. PMID: 25885449
  46. These data demonstrate the crucial requirement for YY1 in lung morphogenesis. PMID: 26329601
  47. Transcription factor YY1 is critically involved in the chromatin remodeling and chromosomal interactions at the Th2 cytokine locus. PMID: 25764217
  48. The somatic Thr372Arg YY1 mutation is a relevant finding in female patients with sporadic insulinomas. PMID: 25763608
  49. YY1 is necessary to maintain the steady-state level of VEGFA expression while its silencing increases VEGFA mRNA half-life at 4 h and impairs the maturation of miRNA 200b/c. PMID: 25644713
  50. YY1 regulates, in a sex-specific manner, Mena expression in heart failure PMID: 25935483
  51. results suggest that YY1 up-regulates UBIAD1 expression and UBIAD1 conversion activity through the UBIAD1 promoter PMID: 25772619
  52. Subsequently, we examined in a subset of the study the expression in blood of two genes regulating mitochondrial biogenesis, YY1 and PGC-1alpha. We found a positive association of YY1 expression and mtDNA content in controls. PMID: 24554339
  53. YY1(T372R) mutations are neomorphic, resulting in constitutive activation of cAMP and Ca(2+) signaling pathways involved in insulin secretion in insulin-producing adenomas PMID: 25787250
  54. Data indicate that the 3'-untranslated region (3'-UTR) of transcription factor Yin Yang 1 (YY1) mRNA was the target of microRNA-34 (miR-34) family consisting of miR-34a, miR-34b, and miR-34c. PMID: 24970812
  55. These data show that hepatitis B virus proteins repress DGCR8 promoter activity by upregulating the expression of transcription factor YY1. PMID: 25427980
  56. YY1 regulated SQSTM1 expression through the epigenetic modulation of the transcription of MIR372 (microRNA 372) which was found to target SQSTM1 directly. PMID: 24991827
  57. Taken together, these results demonstrate that HIV-1 Tat protein suppresses CX3CR1 expression in microglia via NF-kappaB-YY1 pathway and attenuates CX3CL1-induced functional response of microglia. PMID: 24862326
  58. Findings revealed that the expression of YY1 is upregulated in Multiple myeloma, its higher nuclear localization is associated with disease progression. PMID: 24970600
  59. YY1 suppresses invasion and metastasis of pancreatic ductal adenocarcinoma by downregulating MMP10 in a MUC4/ErbB2/p38/MEF2C-dependent mechanism. PMID: 24884523
  60. these findings suggest that YY1-RuvBL1-RuvBL2 complexes could contribute to functions beyond transcription, and we show that YY1 and the ATPase activity of RuvBL2 are required for RAD51 foci formation during homologous recombination. PMID: 24990942
  61. data demonstrated that YY1 contributes to gastric carcinogenesis in gastric cancer. In early stage GACs YY1 might serve as a poor prognostic marker and possibly as a potential therapeutic target PMID: 24674326
  62. The expression of miR-34a in renal cell carcinoma cells displayed an inverse correlation with YY1, but a positive correlation with C/EBPalpha PMID: 24481728
  63. NLRP7 affects trophoblast lineage differentiation, binds to overexpressed YY1 and alters CpG methylation. PMID: 24105472
  64. These results suggest a novel regulatory mechanism for YY1 function by Smurf2. PMID: 24803334
  65. findings define a novel mechanism of Smad7 and YY1 to antagonize TGF-beta signaling PMID: 24369345
  66. T372R mutation alters the expression of YY1 target genes in pancreatic beta-cells of insulinomas. PMID: 24326773
  67. Study identified a novel binding site for YY1 on the HIV-1 LTR, 120 nucleotides upstream of the transcription start site; YY1 can bind to this site in vitro and in vivo and binding to the LTR is dissociated upon T cell activation. PMID: 24116200
  68. Data show that knockdown of Yin Yang 1 (YY1) releases the survivin promoter from the observed repression and leads to a 3- to 5-fold increase in promoter activity above basal levels. PMID: 24508259
  69. The expression of YY1 significantly correlates with that of HO-1 in esophageal squamous cell carcinoma tissues. PMID: 23919806
  70. The cellular factor YY1 played role in varicella-zoster virus replication through the mediation of IE62 activation of viral gene expression. PMID: 24418559
  71. Depletion of YY1 or RelA almost completely impaired the colony forming ability of multiple myeloma(MM) progenitor cells suggesting that both RelA and YY1 are essential for the survival and growth of MM progenitor cells. PMID: 23874387
  72. Little change was observed in SNCA expression levels; however, RP11-115D19.1 expression was prominently stimulated by YY1. PMID: 24026176
  73. Transient YY1 overexpression significantly inhibited MUC4 promoter activity and endogenous MUC4 protein expression. PMID: 23813057
  74. YY1 expression was upregulated in obese mice and non-alcoholic fatty liver disease patients. Overexpression of YY1 in healthy mice promoted hepatosteatosis under high-fat dietary conditions. YY1 suppressed farnesoid X receptor expression. PMID: 23348961
  75. YY1 promotes colon cancer growth through inhibiting p53 and promoting Wnt signaling pathways and serves as an independent prognostic biomarker for colorecatl cancer patients. PMID: 23208495
  76. This is the first study to detect a specific fusion gene in mesothelioma (the reason how frequent the EWSR1-YY1 fusion is remains uncertain) and also the first time that direct involvement of YY1 in oncogenesis has been demonstrated PMID: 23630070
  77. The results confirm association of YY1 and PLK1 with outcome in follicular lymphoma and suggest coexpression at the centrosome. PMID: 23757039
  78. HCFC1 is a common component of active human CpG-island promoters and coincides with ZNF143, THAP11, YY1, and GABP transcription factor occupancy. PMID: 23539139
  79. Knockdown of YY1 led to a significant reduction in GDF5 expression, supporting YY1 as a GDF5 activator. PMID: 22929025
  80. The identification of the general transcription factor Yin Yang 1 (YY1) as a novel and specific binding partner of S6K2, but not S6K1. PMID: 23403125
  81. Our results therefore establish a novel miR-193a-5p-YY1-APC axis, which contributes to endometrioid endometrial carcinoma PMID: 22907428
  82. findings unraveled a novel mechanism by which YY1 inhibition disrupts hypoxia-stimulated HIF-1alpha stabilization in a p53-independent manner PMID: 23328582
  83. Cellular transcription factors Sp1, Sp3 and YY1 bind to the varicella-zoster virus ORF3 promoter, and mutation of their binding sites inhibited ORF3 gene expression. PMID: 23523134
  84. YY1 is a novel substrate of the Aurora B kinase both in vitro and in vivo PMID: 23226345
  85. Binding of YY1 at the -31C Site of IL1B Promoter PMID: 22467534
  86. Study demonstrated that YY1 could promote hepatocellular carcinogenesis and inhibit cellular differentiation through the downregulation of CEBPA expression. PMID: 22391813
  87. Transfection of DLL4 into K562 cells increased the protein expression levels of transcription factor YY1 and proto-oncogene c-Myc, which slowed cell proliferation and increased apoptosis. PMID: 22169291
  88. propose that, in the cell, YY1 may achieve higher specificity by associating with co-regulators or as a part of multi-subunit complexes PMID: 22776217
  89. Two direct YY1 binding sites within the PSCA promoter, an inhibitory upstream site and a downstream site, proximal to the androgen-responsive element, which stimulated PSCA promoter activity. PMID: 22536409
  90. Yin Yang 1 plays an essential role in breast cancer and negatively regulates p27. PMID: 22440256
  91. Data show that bilirubin interacts with the Raf/ERK/MAPK pathway, effect on cyclin D1 and Raf content, altered retinoblastoma protein profile of hypophosphorylation, calcium influx, and YY1 proteolysis. PMID: 22262839
  92. Findings indicate that galiximab inhibits the NF-kappaB/Snail/YY1/Bcl-XL circuit that regulates drug resistance in B-cell lymphoma and in combination with cytotoxic drugs results in apoptosis. PMID: 22267549
  93. Studies indicate that elevated Yin Yang 1 (YY1) expression correlates with higher morphologic grades or malignant histological phenotypes in prostate cancer. PMID: 21326896
  94. Pregnane X receptor and yin yang 1 contribute to the differential tissue expression and induction of CYP3A5 and CYP3A4. PMID: 22292071
  95. analysis of angiotensin II-dependent transcriptional activation of human steroidogenic acute regulatory protein gene by a 25-kDa cAMP-responsive element modulator protein isoform and Yin Yang 1 PMID: 22253417
  96. identify serine 118 in the transactivation domain of YY1 as the site of CK2alpha phosphorylation, proximal to a caspase 7 cleavage site PMID: 22184066
  97. Although there is not a complete consensus about the role of YY1 in cancers based on its activities of regulating oncogene and tumor suppressor expression, most of the currently available evidence supports a role of YY1 in tumorigenesis PMID: 22248053
  98. review highlights the unexplored mechanism through which fluctuations in YY1 protein levels alter the transcriptional status of imprinted genes containing clustered YY1 binding sites, which potentially could affect cancer development and/or progression PMID: 22248054
  99. propose YY1 as a potential novel prognostic biomarker for EMT and a therapeutic target for both the prevention of metastasis and the reversal of resistance PMID: 22248055
  100. discuss the multiple roles and mechanisms of YY1 in the regulation of gene expression, its genetic factor functions, epigenetic regulatory activity, and its role as a redox sensor in the context of malignant neoplastic diseases PMID: 22248056

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Involvement in disease Gabriele-de Vries syndrome (GADEVS)
Subcellular Location Nucleus matrix
Protein Families YY transcription factor family
Database Links

HGNC: 12856

OMIM: 600013

KEGG: hsa:7528

STRING: 9606.ENSP00000262238

UniGene: Hs.388927

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