Recombinant Chicken L-dopachrome tautomerase(DCT)

Code CSB-CF006562CH
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. O93505
Storage Buffer Tris-based buffer,50% glycerol
Species Gallus gallus (Chicken)
Sequence QFPRVCMTVEAIRSKRCCPALGPDPGNVCGVLQGRGWCQGVQVDTQPWSGPYTLRNVDDRERWPLKFFNQSCWCTGNFAGYNCGDCKFGWTGPDCSVRKPPVVRKNIHSLTVEEREQFLDVLDRAKTTIHPDYVIATQHWMSLLGPSGEEPQIANCSIYNYFVWLHYYSVRDTLLGPGRPFTAIDFSHQGPAFVTWHRYHLLLLERDLQRLMGNESFALPYWDFATGRNTCDVCTDQLFGAPRPDDPGLISLNSRFSRWQIVCNSLDDYNRLVTLCNGSDEGLLQRRPRDSGEQLPTAEDVRRCLSRHEFDSPPFFRNSSFSFRNALEGFNKPEGALNSPMLNLHNLAHSFLNGTRVLPHAAANDPIFVVLHSFTDAIFDEWMKRFHPPDNAWPEELAPIGHNRLYNMVPFFPPVTNDQLFQTAEQLGYTYAIDLPGSLEESQAWAAMVGSTIGGALIALAVLVLLLVLFQHRKQRKGFEPLMNVRFSSKKYMEEA
Source in vitro E.coli expression system
Gene Names DCT
Protein Names Recommended name: L-dopachrome tautomerase Short name= DCT Short name= DT EC= 5.3.3.12 Alternative name(s): L-dopachrome Delta-isomerase Tyrosinase-related protein 2 Short name= TRP-2 Short name= TRP2
Expression Region 26-521
Tag Info N-terminal 10xHis-tagged
Protein Description Full Length of Mature Protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels.
Subcellular Location Melanosome membrane, Single-pass type I membrane protein, Melanosome
Protein Families Tyrosinase family
Tissue Specificity Melanocytes and retinal pigmented epithelium.
Database Links

KEGG: gga:395775

STRING: 9031.ENSGALP00000027266

UniGene: Gga.459

Pathway Melanogenesis

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