DCT

DCT (Dopachrome Tautomerase), also termed TRP-2 (Tyrosinase-Related Protein 2) or TYRP2, is a melanosome membrane-bound enzyme of the tyrosinase family. It catalyzes the isomerization of L-dopachrome to DHICA, a critical step in eumelanin biosynthesis, and is regulated by MITF and the Wnt/β-catenin signaling pathway.
DCT mutations cause oculocutaneous albinism type VIII (OCA8), while its overexpression correlates with melanoma progression and drug resistance. Targeting DCT with small-molecule inhibitors or immunotherapies is under preclinical evaluation for melanoma treatment and depigmentation disorder management.