Recombinant Human Beta-secretase 1(BACE1)

Code CSB-CF002524HU
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P56817
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Sequence ETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK
Source in vitro E.coli expression system
Gene Names BACE1
Protein Names Recommended name: Beta-secretase 1 EC= 3.4.23.46 Alternative name(s): Aspartyl protease 2 Short name= ASP2 Short name= Asp 2 Beta-site amyloid precursor protein cleaving enzyme 1 Short name= Beta-site APP cleaving enzyme 1 Memapsin-2
Expression Region 46-501
Tag Info N-terminal 10xHis-tagged
Protein Description Full Length of Mature Protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
Subcellular Location Membrane, Single-pass type I membrane protein, Golgi apparatus, trans-Golgi network, Endoplasmic reticulum, Endosome, Cell surface, Cytoplasmic vesicle membrane, Membrane raft
Protein Families Peptidase A1 family
Tissue Specificity Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.
Database Links

HGNC: 933

OMIM: 604252

KEGG: hsa:23621

STRING: 9606.ENSP00000318585

UniGene: Hs.504003

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