Recombinant Human Bone morphogenetic protein receptor type-1B(BMPR1B)

Code CSB-CF002751HU
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names BMPR1B
Uniprot No. O00238
Alternative Names BMPR1B; Bone morphogenetic protein receptor type-1B; BMP type-1B receptor; BMPR-1B; CD antigen CDw293
Species Homo sapiens (Human)
Expression Region 14-502
Target Protein Sequence KKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction.
Gene References into Functions
  1. Results identified the tumor-suppressive BMPR1B regulated by miR-1274a in clear cell renal cell carcinoma. PMID: 29192325
  2. We detected two BMPR1B mutations in two unrelated PRS families, suggesting that BMPR1B disruption is probably a cause of human PRS. PMID: 28418932
  3. over-expression of CYP2J2 in MDA-MB-468-derived breast cancer cells activates BMPR1B expression that may contribute to increased migration PMID: 27720933
  4. Mutations in three genes (GDF5, NPR2, BMPR1B) have been reported to cause different forms of acromesomelic dysplasia PMID: 26926249
  5. Results show an association between age-induced depletion of the ovarian reserve and BMPR1B receptor density and suggest that the dysregulation of BMP receptor signalling may inhibit the normal steroidogenic differentiation required for maturation in older patients. PMID: 26805635
  6. Low expression of BMPRIB is associated with breast cancer. PMID: 26684357
  7. Two novel mutations in BMPR1B were identified in two patients with brachydactyly type A1. PMID: 25758993
  8. Using computational analyses with the COREX/BEST algorithm, the study uncovered an overall pattern connecting various regions of BMPR-1B ectodomain, including the four conserved residues in the protein-protein interface. PMID: 26562759
  9. Novel mutation in the BMPR1B gene (R486L) in a Polish family and further delineation of the phenotypic features of BMPR1B-related brachydactyly. PMID: 25776145
  10. Data found a hypomorphic BMPR1B mutation causes du Pan acromesomelic dysplasia PMID: 26105076
  11. Disequilibrium of BMP2 levels in the breast stem cell niche launches epithelial transformation by overamplifying BMPR1B cell response. PMID: 25601208
  12. Disrupting the binding of miR-125b toward BMPR1B would increase protein expression, diminishing abnormal cell proliferation as well as serum and cellular CA125 levels PMID: 24339876
  13. Data indicate missense (c.157T>C, p.(C53R)) or nonsense (c.657G>A, p.(W219*)) mutations in bone morphogenetic protein receptor type IB (BMPR1B) in two consanguineous families with acromesomelic chondrodysplasia-type Grebe. PMID: 24129431
  14. the shear-induced apoptosis and autophagy are mediated by bone morphogenetic protein receptor type (BMPR)-IB, BMPR-specific Smad1 and Smad5, and p38 mitogen-activated protein kinase. PMID: 24021264
  15. A significant association was observed between the 455C allele of BMP4 and increased left ventricular internal diameter systolic (p=0.004) and between 1650T allele of BMPR1B and lower left atrium diameter (p=0.038). PMID: 22971142
  16. Suggest that BMPR1B mutations are associated with the pathogenesis of childhood idiopathic pulmonary arterial hypertension. PMID: 22374147
  17. BMP15 uses preferentially BMPR1B as its type I receptor, suggesting an important role for the BMPR1B receptor in human female fertility PMID: 22294741
  18. rs1434536 in the 3'UTR of BMPR1B gene affects the binding ability of miR-125b to BMPR1B mRNA and contributes to the genetic predisposition to localized prostate cancer and patients aged>70 years. PMID: 21556765
  19. BMPR1B were detected in the human retina and retinoblastoma cell lines. PMID: 21152263
  20. performed linkage analysis in brachydactyly (BD) type A2 and mapped a locus for BD type A2 to 4q21-q25. This interval includes the gene bone morphogenetic protein receptor 1B. PMID: 14523231
  21. BMP-2-induced apoptosis was mediated by BMP-RIB in osteoblasts and occurred independently of BMP-2-induced osteoblast differentiation. PMID: 14576167
  22. the BMP system is strongly involved in pulmonary artery smooth muscle mitosis through ALK-6, resulting in the progression of vascular remodeling of pulmonary arteries in pulmonary hypertension. PMID: 15192043
  23. Anti mullerian hormnoe is a gonadal tumor suppressor which mediates its effects through a specific type II receptor and the bone morphogenetic protein (BMP)-specific Smad proteins. PMID: 15897891
  24. GDF5 is a novel brachydactyly type A2 causing gene involving BMPR1b impaired activity. PMID: 16014698
  25. Results indicate that increased bone morphogenetic protein receptor (BMPR)-IB by TGF-beta1, FGF-2, and PDGF-AB significantly enhances BMP-2-induced osteogenesis in vitro. PMID: 17001689
  26. HGF up-regulates the expression of the bone morphogenetic protein receptors, BMPR-IB and BMPR-II, in prostate cancer cells PMID: 17203235
  27. significant shift in the emission maximum from 498 to 510 nm was detected when bis-ANS binds ecBMPR-IB. FRET revealed close proximity between the tyrosine & bis-ANS binding site. PMID: 17363346
  28. Our results indicated the potential involvement of ALK6 activation by rhTGFbetas in the synergy between rhTGFbetas and rhBMPs. PMID: 17381068
  29. there was significant down-regulation of ALK-6 (activin receptor-like kinase 6) expression in asthma patients at baseline; allergy challenge was associated with upregulation PMID: 18292470
  30. Changes in BMPR1B localization regulate osteogenic responses of bone cells to BMP2. PMID: 18619554
  31. the interaction of Ror2 with BRIb is specific and independent of post-translational N-glycosylation. PMID: 19135982
  32. decreased expression of BMPR-IB correlates with poor prognosis in breast cancer patients and leads to increased cell proliferation of breast cancer cells in vitro PMID: 19451094
  33. Decrease BMPR-1B expression led to decreased SMAD1 phosphorylation and correlated witht he malignant grade of human gliomas and a poor prognosis. PMID: 19513897
  34. Results suggest that allele-specific regulation of BMPR1B by miR-125b explains the observed disease risk in breast cancer. PMID: 19738052

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Involvement in disease Acromesomelic dysplasia, Demirhan type (AMDD); Brachydactyly A2 (BDA2); Brachydactyly A1, D (BDA1D)
Subcellular Location Cell membrane. Membrane; Single-pass type I membrane protein.
Protein Families Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
Database Links

HGNC: 1077

OMIM: 112600

KEGG: hsa:658

STRING: 9606.ENSP00000264568

UniGene: Hs.598475

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