Recombinant Human Brain mitochondrial carrier protein 1 (SLC25A14)

Code CSB-CF021480HU
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names
SLC25A14
Uniprot No.
Alternative Names
SLC25A14; BMCP1; UCP5; UNQ791/PRO1682; Brain mitochondrial carrier protein 1; BMCP-1; Mitochondrial uncoupling protein 5; UCP 5; Solute carrier family 25 member 14
Species
Homo sapiens (Human)
Expression Region
1-325
Target Protein Sequence
MGIFPGIILIFLRVKFATAAVIVSGHQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGTFP VDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTI KIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSM IGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFV SSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFW PNWLRLGPWNIIFFITYEQLKRLQI
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Participates in the mitochondrial proton leak measured in brain mitochondria.
Gene References into Functions
  1. Increased expression of cerebral UCP5 and UCP4 is observed in a model of high altitude hypoxia and mitochondrial oxidative phosphorylation deficiency. PMID: 23266757
  2. Neuronal UCP5 exhibits transmembrane chloride transport activity. PMID: 22524567
  3. observed significant associations between genetic variants in the SIRT6 and UCP5 genes and atherosclerotic plaque PMID: 22087257
  4. The enhanced level of UCP5 is associated to mitochondrial dysfunction in colonic cells. PMID: 19910678
  5. expressed in skeletal muscle as three different isoforms; expression level of UCP5SI positively correlated with resting metabolic rate and lipid oxidation rate during a euglycemic clamp with infusion of insulin at a physiologic concentration PMID: 12051969
  6. UCP5 might be physiologically important in the pathology of oxidative stress-induced neurodegeneration PMID: 16941493
  7. The brain may respond to neuroprotection through the increased expression of UCP5 under ischemic conditions. PMID: 18018477

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Subcellular Location
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein Families
Mitochondrial carrier (TC 2.A.29) family
Tissue Specificity
Mainly expressed in brain. Some expression in testis and pituitary.
Database Links

HGNC: 10984

OMIM: 300242

KEGG: hsa:9016

STRING: 9606.ENSP00000218197

UniGene: Hs.194686

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