Recombinant Human CD27 antigen(CD27)

Code CSB-CF004910HU
Size Pls inquire other sizes
Source in vitro E.coli expression system
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Product Details

Target Names CD27
Uniprot No. P26842
Alternative Names CD 27; CD27; CD27 antigen; CD27 molecule; CD27_HUMAN; CD27L receptor; LPFS2; MGC20393; OTTHUMP00000238557; S152; T cell activation antigen CD27; T cell antivation antigen S152; T-cell activation antigen CD27; T14; TNFRSF 7; TNFRSF7; TNFSF7; Tp 55; Tp55; Tumor necrosis factor receptor superfamily member 7
Species Homo sapiens (Human)
Expression Region 20-260
Target Protein Sequence ATPAPKSCPERHYWAQGKLCCQMCEPGTFLVKDCDQHRKAAQCDPCIPGVSFSPDHHTRPHCESCRHCNSGLLVRNCTITANAECACRNGWQCRDKECTECDPLPNPSLTARSSQALSPHPQPTHLPYVSEMLEARTAGHMQTLADFRQLPARTLSTHWPPQRSLCSSDFIRILVIFSGMFLVFTLAGALFLHQRRKYRSNKGESPVEPAEPCHYSCPREEEGSTIPIQEDYRKPEPACSP
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
Gene References into Functions
  1. Results suggests that CD27 could be a marker for poor prognosis for non-ETV6-RUNX1 B-cell precursor acute lymphoblastic leukemia. PMID: 28649984
  2. The authors observed differential expression of CD95(Fas) in CD27(+) B-cells from cirrhotic patients that was inversely correlated with peripheral CD27(+) B-cell frequency. They conclude that peripheral CD27(+) memory B-cells in cirrhosis exhibit increased sensitivity to Fas-induced apoptosis in an activation-dependent manner to which endotoxin contributes, associated with reduced frequency of circulating memory B-cells. PMID: 27857173
  3. Preclinical testing supports the safety and efficacy of a CD27-containing CAR targeting CD70-expressing tumors PMID: 27803044
  4. Crystal structure of CD27 in complex with a neutralizing noncompeting antibody has been reported. PMID: 28471362
  5. High CD27 expression is associated with B-cell Lymphoma. PMID: 28108506
  6. activated CD70-expressing lymphocytes may trigger CD27 on AML blasts or stem/progenitor cells PMID: 28031480
  7. the CD70-CD27 pathway appears to be a crucial component of EBV-specific T cell immunity and more generally for the immune surveillance of B cells and may be a target for immunotherapy of B cell malignancies. PMID: 28011863
  8. This study demonstrates increased level of sCD27 in patients with active vitiligo. PMID: 27556155
  9. This study demonstrated that Soluble CD27 in cerebrospinal fluid of patients with Clinically Isolated Syndrome was associated with multiple sclerosis diagnosis and a high relapse rate. PMID: 28055081
  10. These findings support a potential new role for B cells in dengue pathogenesis, and sCD27 and sCD38 are novel biomarkers associated with clinical outcome during dengue virus infection. PMID: 27467579
  11. Novel mutations in TNFRSF7/CD27 cause EBV-associated lymphoproliferative disease/hemophagocytic lymphohistiocytosis, Hodgkin lymphoma, uveitis, and recurrent infections. PMID: 25843314
  12. NFKB1, CD27, LAG3 and IKZF3 are new susceptibility genes for psoriasis. PMID: 25006012
  13. results provide the first evidence for differential expression of CD27 among CLL prognostic groups, suggest a role for ZAP-70 dependent signaling in CD27 induction and implicate CD27 in cell-cell interactions with the lymphoid tissue microenvironment PMID: 26002513
  14. Multiple layers of memory B cells to T cell- dependent antigens describe immunoglobulin IgM+ B cells representing a memory reservoir that can re-enter the germinal center, ensuring replenishment of class-switched memory CD27+ B cells. PMID: 24965774
  15. Data indicate a unique expansion of CD27(high) plasmablasts in both the cerebrospinal fluid and periphery of transverse myelitis (TM). patients PMID: 23594958
  16. CD27positive B cells from common variable immunodeficiency (CVID) patients are more sensitive than CD27negative B cells to spontaneous apoptosis and less sensitive to rescue from apoptosis; these B cells fail to differentiate to memory or plasma cells. PMID: 23738704
  17. lack of functional CD27 predisposes towards a combined immunodeficiency associated with potentially fatal EBV-driven hemo-phagocytosis, lymphoproliferation, and lymphoma development. PMID: 22801960
  18. The CCR7+CD45RA-CD27+CD28+ central memory subset is significantly decreased in the peripheral blood CD4+ T cells from rheumatoid arthritis patients. PMID: 23747721
  19. We identified soluble CD27 as an immune modulator associated with enhanced human T cell activation PMID: 23677477
  20. These results highlight the importance of the CD27-CD70 costimulation pathway for the development of CMV-specific T cell immunity during acute and persistent infection. PMID: 23576505
  21. The expression of CD27 together with CD44 showed a relationship with several established risk factors as well as response to therapy, indicating the biological significance of these molecules in acute lymphoblastic leukemia PMID: 23263849
  22. CD27 and CD28 costimulatory receptors play central roles in differentiation and activation of gamma-delta T Lymphocytes. (Review) PMID: 23456842
  23. IgM(+)IgD(+)CD27(+) but not switched B cells were strongly reduced in MYD88-, IRAK-4-, and TIRAP-deficient patients, but not UNC-93B-deficient patients. PMID: 23002119
  24. serum sCD27 level is associated with CD27 expression on lymphoma cells, and may have a role in diffuse large B-cell lymphoma PMID: 22280534
  25. These results indicate that CD27 and CD70 gene polymorphisms may affect the risk of breast cancer and show that some SNPs are associated with breast cancer characteristics in a northern Chinese population. PMID: 22399187
  26. Decreased CD27 on B lymphocytes in patients with primary hepatocellular carcinoma. PMID: 22429370
  27. gene deficiency is associated with combined immunodeficiency and symptomatic EBV viremia PMID: 22197273
  28. down-regulation of CD27 on MTB-specific CD4 T cell could be used as a biomarker of active TB, potentially preceding clinical TB disease PMID: 22087280
  29. Data show that in a mouse model of chronic myelogenous leukemia, BCR/ABL+ leukemia stem and progenitor cells express CD27, and reveal a mechanism by which adaptive immunity contributes to leukemia progression. PMID: 22232214
  30. Data show that CD27(+)/IgD(-)/ZAP70(+) memory B cells accumulate preferentially in the joints of RA, suggesting a dynamic maturation of the B cells in this compartment. PMID: 21607290
  31. CD27 signalling does influence T(H) cell differentiation. PMID: 21277898
  32. CD27(+) lymphocytes represent abnormal mononuclear cell populations in atrophic oral lichen planus (OLP) lesions indicating forms of OLP might exist with different pathogenesis, despite similar histology and clinical behavior. PMID: 21237436
  33. no correlation between expression on T-lymphocytes and sera levels in children with asthma PMID: 20800938
  34. CD27 may have a role in infection in systemic lupus erythematosus PMID: 20879061
  35. In this review, CD27 and CD70 constitute a unique ligand and receptor pair which can activate innate and adaptive immunity as well as regulate immunity versus tolerance. PMID: 20699361
  36. These data collectively establish a novel role for the CD70-CD27 axis in human gammadelta T-cell activation and hence open new perspectives for its modulation in clinical settings. PMID: 21182090
  37. Compared with tuberculin-positive controls, patients with bacterial culture-positive pulmonary TB had significantly reduced CD27 expression on antigen-specific CD4 T cells PMID: 20393787
  38. higher proportion of protein-expressing B-cells in the blood of patients with systemic lupus erythematosus PMID: 19866343
  39. the CD70-CD27 interaction may play an important role in inducing effective immune responses in dendritic cell-based PMID: 20201989
  40. Systemic lupus erythematosus flares may relate to the retention of CD27+ memory B cells. (review) PMID: 15230280
  41. Functionally differentiated Vgamma9delta2+ T cells lack CD27 expression and are found in reduced numbers in immunocompromised hosts (such as healthy newborns and HIV-infected adults) and during active pulmonary tuberculosis. PMID: 11801693
  42. Increased levels of soluble CD27 in the cerebrospinal fluid are not diagnostic for leptomeningeal involvement by lymphoid malignancies.The positive predictive value of sCD27 determination for LI was only 54%, but the negative predictive value was 92%. PMID: 11976819
  43. intragraft gene expression is a risk factor for acute cardiac allograft rejection PMID: 12009595
  44. IL-10 enhances B-cell IgE synthesis by promoting differentiation into plasma cells, a process that is inhibited by CD27/CD70 interaction PMID: 12197885
  45. CD27 and CD40 co-stimulatory signals regulated the p53-amplified apoptotic pathway in B cells through the inhibition of p53-independent apoptotic pathway primarily induced by BCR ligation PMID: 12324477
  46. CD27(-) effector CD8(+) T cells might be required for adequate control of chronic viral infection and prevention of disease development. PMID: 12464570
  47. CD148 and CD27 are expressed in a wide range of B cell non-Hodgkin's lymphomas and do not serve to distinguish between neoplastic cells of naive and memory B cell derivation PMID: 12685844
  48. In indolent lymphomas, sCD27 proved to be a powerful marker to predict progression-free survival (p = 0.008). PMID: 12743427
  49. Signals through CD70 in B lymphocytes of CD70 transgenic mice result in enhanced cell cycle entry while preventing differentiation into IgG-secreting plasma cells. PMID: 15356138
  50. In primary biliary cirrhosis CpG led to a markedly high frequency of intracellular IgM-positive B cells, associated with high levels of synthesized IgM and identified to be a function of CD27(+) memory B cells. PMID: 15685542
  51. functional and lineage relationships of three distinct memory CD4 subpopulations distinguished by their expression of the cysteine chemokine receptor CCR7 and the TNFR family member CD27 PMID: 16272303
  52. Interaction of CD70 with CD27 plays a direct role in T cell activation mediated by IL-2. PMID: 16751420
  53. In systemic lupus erythematosus (SLE) patients, significant increases of CCR7-, CD27- and CCR7-, CD27+ and a reduction of CCR7+, CD27+ CD4 memory T cells were found. PMID: 16802356
  54. The memory B cell reservoir extends beyond the CD27+ compartment because B cells expressing surface IgG, but not CD27, have been found in human blood and provide further insights into B cell disorders of unknown etiology. PMID: 16951333
  55. In systemic lupus erythematosus, an increased frequency of CD27-negative memory cells is significantly associated with higher disease activity index and disease-specific autoantibodies. PMID: 17475894
  56. CD27-CD70 interactions may promote Th1 cell formation by permitting naive T cells to respond to differentiation signals and by promoting survival of activated effector T cells. PMID: 17548342
  57. Failure to increase surface expression of costimulatory molecules CD27 and CD28 following stimulation may contribute to naive T cell impairment in HIV infection. PMID: 17785788
  58. marginal zone-like IgM(+)CD27(+) B cells are clonally expanded in certain subjects with mixed cryoglobulinemia (MC) offers insight into mechanisms of HCV-associated MC and B-cell malignancy PMID: 17942751
  59. Expression defines phenotypic stages in B cell precursor development. PMID: 18005092
  60. A functional role for sCD27 in WM(Waldenstrom macroglobulinemia) pathogenesis, along with its utility as a surrogate marker of disease and a target in the treatment of WM. PMID: 18216294
  61. Lack of CD27 expression on natural killer (NK) cells is associated with high cytolytic function and, in combination with CD56, allows a better definition of cytotoxic effector cells. PMID: 18322179
  62. a homogeneous subset of CD27-,IgD-,CD95+ memory B cells with an activated phenotype was identified in lupus patients PMID: 18512812
  63. CD70/CD27 interaction provides a critical stimulus for expanding effector T cells, enhancing their cytotoxic activity and improving the antileukemic effector response. PMID: 19109206
  64. The absolute number of B lymphocytes and the percentage of naive cells (CD23-/CD27-) decreased with age whereas there was an increase in memory cells (CD27+). PMID: 19290077
  65. This is the first study which (i) extensively analyzes CD70 expression on human primary DC subsets and (ii) reveals that the CD70-CD27 interaction enhances not only Th1 but also Th2 differentiation of naive CD4+ T cells. PMID: 19556308
  66. A double-negative (IgD-CD27-) B cell population is increased in the peripheral blood of elderly people. PMID: 19698733
  67. CD19(+)IgM(+)D(+)CD27(-ve) memory B cells may have a distinct lineage and function, and seem relevant to understanding origins of malignant B cells, in particular those of hairy cell leukemia cells, which display mutated V genes yet lack CD27 expression PMID: 19776762

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Involvement in disease Lymphoproliferative syndrome 2 (LPFS2)
Subcellular Location Membrane, Single-pass type I membrane protein
Tissue Specificity Found in most T-lymphocytes.
Database Links

HGNC: 11922

OMIM: 186711

KEGG: hsa:939

STRING: 9606.ENSP00000266557

UniGene: Hs.355307

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