CD27, a crucial member of the tumor necrosis factor receptor superfamily, is a transmembrane phosphoglycoprotein primarily expressed on T cells, B cells, and hematopoietic stem cells. Structurally, it activates downstream signaling pathways through binding with its ligand, CD70. Functionally, CD27 serves as a marker of T cell activation and memory, participating in the regulation of antigen-specific immune responses and maintaining the stability of the T cell memory pool. In B cells, CD27 promotes long-term immune protection. In terms of signaling, the interaction between CD27 and CD70 triggers a cascade of signal transduction processes involving Traf2, Traf5, and NF-κB, ultimately enhancing the survival and activation of immune cells. Additionally, the interaction between CD27 and CD70 holds potential in tumor immunotherapy, with its regulatory mechanisms emerging as a new direction in immunotherapy research. Through in-depth investigation of the structure, function, and signaling pathways of CD27, we aim to gain a deeper understanding of its role in the immune system and pave the way for novel therapeutic strategies targeting related diseases.
CD27 Recombinant Monoclonal Antibody
Validated Data
Positive WB detected in: Daudi whole cell lysate, HL-60 whole cell lysate, THP-1 cell lysate, K562 cell lysate
All lanes: CD27 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 30 kDa
Observed band size: 55 kDa
The following CD27 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
CD27 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA004910GA01HU | CD27 Antibody |
Human | ELISA,WB |
CSB-PA08235A0Rb | CD27 Antibody |
Human, Rat | ELISA, WB, IHC, IF |
CSB-PA123791 | CD27 Antibody |
Human | ELISA,WB,IHC |
CSB-PA149291 | CD27 Antibody |
Human | ELISA,WB,IHC |
CSB-RA953976A0HU | CD27 Recombinant Monoclonal Antibody |
Human | ELISA, WB |
CD27 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP004910HU1 CSB-EP004910HU1 CSB-BP004910HU1 CSB-MP004910HU1 CSB-EP004910HU1-B |
Recombinant Human CD27 antigen (CD27), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF004910HU | Recombinant Human CD27 antigen (CD27) |
in vitro E.coli expression system |